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174
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ShareScore release 0.9.0
Dataset results
174 results for “Neurofibromatosis I”
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
ClinicalTrials.gov study NCT03962543. IPD Sharing: YES. Countries: 1. Publications: 1.
Optical coherence tomography of the macular ganglion cell layer in children with neurofibromatosis type 1 is a useful tool in the assessment for optic pathway gliomas
<p><span>To investigate whether the ganglion cell layer assessed by OCT is a reliable measure to identify and detect relapses of symptomatic OPGs in children with NF1.</span></p>
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas
ClinicalTrials.gov study NCT00021541. IPD Sharing: NO. Countries: 2. Publications: 4.
Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)
ClinicalTrials.gov study NCT01207687. IPD Sharing: NO. Countries: 1. Publications: 1.
Auditory Brainstem Implant (ABI) in Adult Non-Neurofibromatosis Type 2 Subjects
ClinicalTrials.gov study NCT01736267. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT00853580. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT04481035. IPD Sharing: NO. Countries: 1. Publications: 27.
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
ClinicalTrials.gov study NCT02839720. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT04481048. IPD Sharing: NO. Countries: 1. Publications: 28.
Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas
ClinicalTrials.gov study NCT01673009. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Hypnosis and Home Blood Pressure Monitoring in Children With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT05196854. IPD Sharing: YES. Countries: 1. Publications: 2.
Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas
ClinicalTrials.gov study NCT00076102. IPD Sharing: NO. Countries: 1. Publications: 4.
Auditory Brainstem Implant (ABI) in Pediatric Non-Neurofibromatosis Type 2 Subjects
ClinicalTrials.gov study NCT01864291. IPD Sharing: NO. Countries: 1. Publications: 7.
Predictive modeling for clinical features associated with Neurofibromatosis Type 1
<p>Objective: Perform a longitudinal analysis of clinical features associated with Neurofibromatosis Type 1 (NF1) based on demographic and clinical characteristics, and to apply a machine learning strategy to determine feasibility of developing exploratory predictive models of optic pathway glioma (OPG) and attention-deficit/hyperactivity disorder (ADHD) in a pediatric NF1 cohort.</p> <p>Methods: Using NF1 as a model system, we perform retrospective data analyses utilizing a manually-curated NF1 clinical registry and electronic health record (EHR) information, and develop machine-learning models. Data for 798 individuals were available, with 578 comprising the pediatric cohort used for analysis.</p> <p>Results: Males and females were evenly represented in the cohort. White children were more likely to develop OPG (OR: 2.11, 95%CI: 1.11-4.00, p=0.02) relative to their non-white peers. Median age at diagnosis of OPG was 6.5 years (1.7-17.0), irrespective of sex. Males were more likely than females to have a diagnosis of ADHD (OR: 1.90, 95%CI: 1.33-2.70, p<0.001), and earlier diagnosis in males relative to females was observed. The gradient boosting classification model predicted diagnosis of ADHD with an AUROC of 0.74, and predicted diagnosis of OPG with an AUROC of 0.82.</p> <p>Conclusions: Using readily available clinical and EHR data, we successfully recapitulated several important and clinically-relevant patterns in NF1 semiology specifically based on demographic and clinical characteristics. Naïve machine learning techniques can be potentially used to develop and validate predictive phenotype complexes applicable to risk stratification and disease management in NF1.</p>
Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1
ClinicalTrials.gov study NCT02211768. IPD Sharing: YES. Countries: 1. Publications: 3.
Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients
ClinicalTrials.gov study NCT01222728. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
ClinicalTrials.gov study NCT02104323. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)
ClinicalTrials.gov study NCT04590235. IPD Sharing: YES. Countries: 1. Publications: 0.
Adaptation and Quality of Life Among Adults With Neurofibromatosis Type I
ClinicalTrials.gov study NCT00684398. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Natural History Study of Patients With Neurofibromatosis Type I
ClinicalTrials.gov study NCT00924196. IPD Sharing: YES. Countries: 1. Publications: 7.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.