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40
datasets available to search
ShareScore release 0.9.0
Dataset results
40 results for “Neuron Damage”
Microembolic Signals and Cerebrospinal Fluid Markers of Neuronal Damage After Surgical Aortic Valve Replacement
ClinicalTrials.gov study NCT01319799. IPD Sharing: NO. Countries: 1. Publications: 6.
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
ClinicalTrials.gov study NCT05692804. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Characterizing the Immune Response and Neuronal Damage in COVID-19
ClinicalTrials.gov study NCT04510012. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy
ClinicalTrials.gov study NCT03590197. IPD Sharing: UNDECIDED. Countries: 1. Publications: 32.
Effect of Steroids on Cerebral Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement
ClinicalTrials.gov study NCT01755338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prognosis Value of the Neuronal Damage in Early Multiple Sclerosis
ClinicalTrials.gov study NCT01651520. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Microembolic Signals and Serum Markers of Neuronal Damage During Transcatheter Aortic Valve Implantation.
ClinicalTrials.gov study NCT01237743. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was blocked by acidic lipids and competed by other basic proteins. Further studies revealed that MBP induced damage to neuronal membrane integrity and function by depolarizing the resting membrane potential, increasing the permeability to cations and other molecules, and decreasing the membrane fluidity. At last, artificial liposome vesicle assay showed that MBP directly disturbed acidic lipid bilayer and resulted in increased membrane permeability. These results revealed that MBP induces neurotoxicity through its direct interaction with acidic components on the extracellular surface of neuronal membrane, which may suggest a possible contribution of MBP to the pathogenesis in the CNS disorders with myelin damage.
Figure 4 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 4 Immunohistochemical staining of Caspase-3 400× microscope magnification. Picture of caspase 3 expression in the cerebral cortex area shows a picture of caspase 3 expression in the cytoplasm of neuron cells (yellow arrow). A. The normal control group showed a score of 0; B. The negative control group shows a score of 4; C. Group A shows a score of 3; D. Group B shows a score of 2; E. Group C shows a score of 1.
Figure 5 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 5 Histopathological picture of brain tissue damage with HE staining, 400× microscope magnification. Description: Histopathological picture of the cerebral cortex area shows degeneration of neuron cells (yellow arrows). A. The normal control group shows a score of 0; B. The negative control group shows a score of 2; C. Group A shows a score of 2; D. Group B shows a score of 1; E. Group C shows a score of 1.
Figure 2 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 2 TLR4 immunohistochemical staining with a microscope magnification of 400×. Description: TLR4 expression in the cerebral cortex area shows TLR4 expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 20%; C. Group A expressed 15%; D. Group B expressed 15%; E. Group C expressed 10%.
Figure 3 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 3 TNF-α immunohistochemical staining with a microscope magnification of 400×. TNF-α expression in the cerebral cortex area shows TNF-α expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 15%; C. Group A was depressed 10%; D. Group B expressed 10%; E. Group C expressed 5%.
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
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CCR5 controls neuronal damage in an in vivo model of HIV glycoprotein 120-induced brain injury
GEO Series GSE47029. Mus musculus. 225 samples. Type: Expression profiling by array.
Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [bulkRNA-Seq]
GEO Series GSE287862. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Macrophages amplify damaged sensory neuron spontaneous activity in a human co-culture model of neuropathic pain [mouse]
GEO Series GSE298326. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Whole-genome gene expression profiling of dorsal root ganglion neurons after nerve damage
GEO Series GSE21007. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Targeting MLKL alleviates neuroinflammation and prevents motor neuron damage in Parkinson’s traits
GEO Series GSE197679. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Osmosensory neurons modulate hypertonic stress resistance in C. elegans by controlling protein damage in non-neuronal cells
GEO Series GSE73589. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Human microglia carrying an early-onset Parkinson’s disease mutation display cell-autonomous disease-relevant phenotypes that may worsen neuronal damage
GEO Series GSE241437. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.