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440 results for “Neuroprotection”
Peripheral MC1R activation modulates immune responses and confers neuroprotection in a mouse model of Parkinson's disease
<p>Raw data sets for the manuscripts</p> <p>This work was supported by NIH grants R01NS102735 and R01NS110879, the Farmer Family Foundation Initiative for Parkinson’s Disease Research and the MJFF and ASAP [ASAP-000312].</p>
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
<p><a title="Learn more about Tacrine from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/chemistry/tacrine">Tacrine</a> (THA), a long withdrawn drug, is still a popular scaffold used in medicinal <a title="Learn more about chemistry from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/chemistry/chemistry">chemistry</a>, mainly for its good reactivity and multi-targeted effect. However, THA-associated hepatotoxicity is still an issue and must be considered in <a title="Learn more about drug discovery from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-discovery">drug discovery</a> based on the THA scaffold. Following our previously identified hit compound 7-phenoxytacrine (7-PhO-THA), we systematically explored the chemical space with 30 novel derivatives, with a focus on low hepatotoxicity, <a title="Learn more about anticholinesterase from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cholinesterase-inhibitor">anticholinesterase</a> action, and antagonism at the GluN1/GluN2B subtype of the <a title="Learn more about NMDA receptor from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/n-methyl-dextro-aspartic-acid-receptor">NMDA receptor</a>. Applying the down-selection process based on <em>in vitro</em> and <em>in vivo</em> <a title="Learn more about pharmacokinetic from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pharmacokinetics">pharmacokinetic</a> data, two candidates, <strong>I-52</strong> and <strong>II-52,</strong> selective GluN1/GluN2B inhibitors thanks to the interaction with the ifenprodil-binding site, have entered <em>in vivo</em> <a title="Learn more about pharmacodynamic from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/pharmacodynamics">pharmacodynamic</a> studies. Finally, compound <strong>I-52,</strong> showing only minor affinity to <a title="Learn more about AChE from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/acetylcholinesterase">AChE</a>, was identified as a lead candidate with favorable behavioral and <a title="Learn more about neuroprotective from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/neuroprotective-agent">neuroprotective</a> effects using open-field and <a title="Learn more about prepulse inhibition from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/prepulse-inhibition">prepulse inhibition</a> tests, along with scopolamine-based behavioral and NMDA-induced hippocampal lesion models. Our data show that compound <strong>I-52</strong> exhibits low toxicity often associated with <a title="Learn more about NMDA receptor from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nmda-receptor">NMDA receptor</a> ligands, and low hepatotoxicity, often related to THA-based compounds.</p>
Figure 2 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 2. LF Chromatogram (a) and the mass spectrum of presumed (b) Hinokinin, (c) Cubebin, (d) Yatein by UPLC-MS.
Figure 3 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 3. Antioxidant activities on rat's brain based on activities of lipid peroxidation inhibition (a), SOD (b) and CAT (c) activities, and NO concentration (d) of lignan-rich fraction of P.cubeba 200 mg/kg (LF-200), 400 mg/kg (LF-400), Vitamin C 200 mg/kg (Vit-C), and normal control (N). The results are present as the mean ± SEM, asignificantly different compared to the N group (p<0.01), bsignificantly different compared to the N group (p<0.05).
Data from: Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2driven and idiopathic Parkinson’s disease
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Dataset for article: Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects
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Hop Flower Supercritical Carbon Dioxide Extracts Coupled with Carriers with Solubilizing Properties—Antioxidant Activity and Neuroprotective Potential
<p>Article, Dataset for article</p> <p> </p> <h1>Hop Flower Supercritical Carbon Dioxide Extracts Coupled with Carriers with Solubilizing Properties—Antioxidant Activity and Neuroprotective Potential</h1> <p> </p> <h2>Abstract</h2> <div><span>Lupuli flos</span> shows many biological activities like antioxidant potential, extended by a targeted effect on selected enzymes, the expression of which is characteristic for neurodegenerative changes within the nervous system. <span>Lupuli flos</span> extracts (LFE) were prepared by supercritical carbon dioxide (scCO<sub>2</sub>) extraction with various pressure and temperature parameters. The antioxidant, chelating activity, and inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase by extracts were studied. The extracts containing ethanol were used as references. The most beneficial neuroprotective effects were shown by the extract obtained under 5000 PSI and 50 °C. The neuroprotective effect of active compounds is limited by poor solubility; therefore, carriers with solubilizing properties were used for scCO<sub>2</sub> extracts, combined with post-scCO<sub>2</sub> ethanol extract. Hydroxypropyl-β-cyclodextrin (HP-β-CD) in combination with magnesium aluminometasilicate (Neusilin US2) in the ratio 1:0.5 improved dissolution profiles to the greatest extent, while the apparent permeability coefficients of these compounds determined using the parallel artificial membrane permeability assay in the gastrointestinal (PAMPA GIT) model were increased the most by only HP-β-CD.</div> <div> <div> <div>Keywords: </div> <a href="https://www.mdpi.com/search?q=neuroprotection">neuroprotection</a>; <a href="https://www.mdpi.com/search?q=hop+strobile">hop strobile</a>; <a href="https://www.mdpi.com/search?q=inhibition+of+enzymes">inhibition of enzymes</a>; <a href="https://www.mdpi.com/search?q=xanthohumol">xanthohumol</a></div> </div>
The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2
<p>Article, Dataset for the article</p> <p> </p> <h2>Abstract</h2> <div><span>Cannabis sativa</span>, a versatile plant with numerous varieties, holds promising potential for a wide range of biological activity. As raw materials for research, we chose leaves and inflorescences of hemp varieties such as Białobrzeskie, Henola, and Tygra, which are cultivated mainly for their fibers or seeds. The choice of extraction is a key step in obtaining the selected compositions of active compounds from plant material. Bearing in mind the lipophilic nature of cannabinoids, we performed supercritical carbon dioxide (scCO<sub>2</sub>) extraction at 50 °C under 2000 (a) and 6000 PSI (b). The cannabinoid contents were determined with the use of the HPLC-DAD method. The antioxidant capabilities were assessed through a series of procedures, including the DPPH, ABTS, CUPRAC, and FRAP methods. The capacity to inhibit enzymes that play a role in the progression of neurodegenerative diseases, such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase was also studied. The dominant cannabinoids in the extracts were cannabidiol (CBD) and cannabidiolic acid (CBDA). The highest concentration of eight cannabinoids was detected in the Tygra inflorescences extract (b). The most notable antioxidant properties were provided by the Tygra inflorescences extract (b). Nonetheless, it was the Henola inflorescences extract (b) that demonstrated the most efficient inhibition of AChE and BChE, and tyrosinase was inhibited the most significantly by the Białobrzeskie inflorescences extract (b). Multidimensional comparative analysis enrolled all assays and revealed that the Henola inflorescences extract (b) showed the most substantial neuroprotective potential.</div> <div> <div> <div>Keywords: </div> <a href="https://www.mdpi.com/search?q=Cannabis+sativa"><span>Cannabis sativa</span></a>; <a href="https://www.mdpi.com/search?q=antioxidant">antioxidant</a>; <a href="https://www.mdpi.com/search?q=neuroprotection">neuroprotection</a></div> </div>
DESIGN, SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITY OF PEPTIDES WITH NEUROPROTECTIVE PROPERTIES
<p>The main purpose of this project is to search for novel compounds that will protect neurons against oxidative stress (6-hydroxydopamine, 6-OHDA) and glucocorticoids (corticosterone, CORT) in a human neuroblastoma cell line (SH-SY5Y) and elucidate the mechanism by which attenuated the physiological changes induced by these neurotoxins. We will explore whether this protective role of tested compounds will be involved also in the regulation of apoptosis, maintaining oxidoreductive balance, and stabilization of mitochondrial membrane potential. Furthermore, the involvement of the BDNF/TrkB-ERK-CREB/mTOR signalling pathway in neuronal survival will be examined.</p>
Data from: Neuroprotection provided by hypothermia initiated with high transnasal flow with ambient air in a model of pediatric cardiac arrest
<p>Clinical trials of hypothermia after pediatric cardiac arrest have not seen robust improvement in functional outcome, possibly because of the long delay in achieving target temperature. Previous work in infant piglets showed that high nasal airflow, which induces evaporative cooling in the nasal mucosa, reduced regional brain temperature uniformly in half the time needed to reduce body temperature. The mouth is kept open to allow the high nasal airflow to easily exit. Here, we evaluated whether initiation of hypothermia with high transnasal airflow (32 L/min) provides neuroprotection without adverse effects in the setting of asphyxic cardiac arrest. Anesthetized, mechanically ventilated piglets (approximately 2-weeks-old) underwent sham-operated procedures (Group 1) or asphyxic cardiac arrest (Groups 2-6). The asphyxic insult consisted of reducing the inspired oxygen from 30% to 9.5-10% for 45 minutes (hypoxia period), then briefly increasing the inspired oxygen to 21% for 5 min (to improve the later success of cardiac resuscitation), and then completely stopping ventilation for 7 minutes. Cardiopulmonary resuscitation (CPR) commenced by re-establishing ventilation, performing chest compression, and injecting epinephrine as needed. The five cardiac arrest groups were further divided into those with normothermic recovery (38.5°C; Group 2), with mild hypothermia (34°C) initiated by surface cooling at 10 minutes (Group 3) or 120 minutes (Group 5) after resuscitation, or with mild hypothermia (34°C) initiated by transnasal cooling initiated at 10 minutes (Group 4) or 120 minutes (Group 6) after resuscitation. In the two transnasal cooling groups, the high nasal airflow continued for 2 hours and was then stopped; thereafter, surface cooling was used to maintain hypothermia. In all four groups with induced hypothermia, rectal temperature was sustained at the targeted temperature of 34°C with surface cooling until 20 hours after resuscitation, followed by 6 hours of gradual rewarming and cessation of fentanyl/70% nitrous oxide anesthesia.<strong> </strong>At four days of recovery, the piglets were euthanized and their brains were analyzed for the density of morphologically intact neurons in putamen, sensorimotor cortex, ventrolateral thalamus, and prefrontal cortex. The data sheet shows the density of viable neurons in these 4 brain regions for the 45 piglets that completed the study. The data sheet also shows the serial measurements of rectal temperature, mean arterial blood pressure, heart rate, and arterial blood measurements of the partial pressure of oxygen (PO2) and carbon dioxide (PCO2), oxyhemoglobin saturation, and pH obtained at baseline, during the period of hypoxia, at 4 minutes of ventilation with 21% O2, during the period of asphyxia, and during the first 24 hours of recovery. The piglets are assigned the same unique identifier number, labelled 1-45, for each set of measurements. Transnasal cooling initiated at 10 minutes after resuscitation was able to significantly rescue neurons in the highly vulnerable putamen without adverse effects.</p>
Figure 6 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 6. Treatment Group with resveratrol standard after induced by Beta-Amyloid (10 x10).
Figure 3 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 3. Treatment group: 2- ME + Resveratrol isolated from Tempeh (10 x10).
Figure 1 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 1. TLC analysis result of LF showed the presence of cubebin and other lignans.
Figure 8 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 8. Treatment Group with resveratrol tempeh + 2-ME after induced by Beta-Amyloid (10 x10).
Figure 5 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 5. Treatment group: 2- ME (10 x10).
Figure 9. Treatment Group with 2 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 9. Treatment Group with 2-ME after induced by Beta-Amyloid (10 x10).
Figure 2 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 2. Treatment group: 2- ME + Resveratrol Standard (10 x10).
Figure 1 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol
Figure 1. Control Group (10 x10).
Table 4 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2 - methoxyethanol
<p><b>Table 4.</b> Cytotoxic effect of various concentrations of Resveratrol and 2-Methoxyethanol Against Primary Neuron cell viability in MTT assay (570 nm).</p><table><tbody><tr><th><b>% Inhibition</b></th></tr></tbody><tbody><tr><th><b>Concentration of 2-Methoxyethanol</b></th><td><b>2-ME (10mM)</b></td><td><b>2-ME (10mM)</b></td><td><b>2-ME (10mM)</b></td></tr><tr><th><b>and Resveratrol</b></th><td><b>Resveratrol (Standard)</b></td><td><b>Resveratrol (Tempeh)</b></td><td><b>Resveratrol (Soybean Seed Coat)</b></td></tr><tr><th>IC50</th><td>(17.38 ± 0.99 µg/mL)</td><td>(31.14 ± 0.02 µg/mL)</td><td>(13.40 ± 0.30 µg/mL)</td></tr><tr><th>1.4 (µg/mL)</th><td>12.57</td><td>0</td><td>11.98</td></tr><tr><th>2.8 (µg/mL)</th><td>4.59</td><td>1.75</td><td>17.03</td></tr><tr><th>4.2 (µg/mL)</th><td>0</td><td>0</td><td>0</td></tr></tbody></table>
Table 3 in Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2 - methoxyethanol
<p><b>Table 3.</b> Cytotoxic effect of various concentrations of Resveratrol and 2-Methoxyethanol Against Primary Neuron cell viability in MTT assay (540 nm).</p><table><tbody><tr><th><b>% Inhibition</b></th></tr></tbody><tbody><tr><th><b>Concentration of 2-Methoxyethanol</b></th><td><b>2-ME (10mM)</b></td><td><b>2-ME (10mM)</b></td><td><b>2-ME (10mM)</b></td></tr><tr><th><b>and Resveratrol</b></th><td><b>Resveratrol (Standard)</b></td><td><b>Resveratrol (Tempeh)</b></td><td><b>Resveratrol (Soybean Seed Coat)</b></td></tr><tr><th>IC50</th><td>(17.64 ± 0.99 µg/mL)</td><td>(32.22 ± 1.18 µg/mL)</td><td>(17.43 ± 0.16 µg/mL)</td></tr><tr><th>1.4 (µg/mL)</th><td>11.8</td><td>0</td><td>7.95</td></tr><tr><th>2.8 (µg/mL)</th><td>5.27</td><td>0</td><td>14.41</td></tr><tr><th>4.2 (µg/mL)</th><td>0</td><td>0</td><td>0</td></tr></tbody></table>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.