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49 results for “Opioid Analgesic”
The Effect of Prescription Drug Monitoring Programs (PDMPs) and Overdose Reversal Drug Accessibility Laws on Opioid Analgesic Mortality in the United States
<p><strong>Purpose: </strong>This analysis focuses on the impact of Prescription Drug Monitoring Programs (PDMPs) and increased layperson access to the overdose reversal drug Naloxone on prescription opioid mortality rates. The prescription opioid mortality rate was analyzed against state laws governing PDMPs and Naloxone accessibility to laypersons to evaluate if there was a correlation between mortality reduction and implementation of the laws.</p> <p>Three main analyses were conducted:</p> <ol> <li>Does a state’s opioid mortality reduction correlate to an effective PDMP and/or Naloxone law?</li> <li>Do states with strong PDMP laws have a corresponding opioid overdose mortality rate reduction?</li> <li>Do states with strong Naloxone accessibility laws have a corresponding opioid overdose mortality rate reduction?</li> </ol> <p><strong>Conclusion:</strong> Patterns show that PDMP and Naloxone accessibility can be successful in reducing mortality rates, but implementations and results vary dramatically between states. Further changes to both PDMPs and Naloxone accessibility are needed for states to see reliable and consistent mortality reductions. Changes to regulations need time to implement and take effect, meaning longer term measurements and data will be required to see if positive impacts can be sustained.</p> <ol> </ol> <p><strong>Data and Datasets:</strong></p> <p>There are three main datasets used in the analysis.</p> <ul> <li>Opioid mortality rate by state from 2006 to 2016. <ul> <li>This datasetis from the CDC website (<a href="https://www.cdc.gov/drugoverdose/data/statedeaths.html">https://www.cdc.gov/drugoverdose/data/statedeaths.html</a>). I used web scraping and regular expression search to extract the data and calculated mortality reduction of each state.</li> <li><em>Mortality reduction formula: (Highest mortality rate) – (2016 mortality rate)</em><br> </li> </ul> </li> <li>PDMP law implementation in each state and its timelinefrom January 1, 1998 to July 1, 2016. <ul> <li>Dataset is from the Prescription Drug Abuse Policy System(<a href="http://pdaps.org./datasets/prescription-monitoring-program-laws-1408223332-1502818372">http://pdaps.org./datasets/prescription-monitoring-program-laws-1408223332-1502818372</a>). This dataset encompasses laws regulating which professions have access to the database and for what purpose, whether practitioners can delegate their access, whether patients can see their own information, and the extent to which access to individually-identified records may be granted for law enforcement purposes.</li> <li>This dataset is not quantitative, but a set of questions on the characteristics of the laws governing the PDMP.I performed the following data preparation to allow for analysis and visualization:</li> <li><em>PDMP law effectiveness calculation:Each question with a “Yes” answer adds one point to the law’s cumulative effectiveness score on the year it was implemented.</em></li> </ul> </li> </ul> <ul> <li>Naloxone accessibility to laypersons law implementation in each state and its timeline from January 1, 2001 to December 31, 2016. <ul> <li>Dataset is also from the Prescription Drug Abuse Policy System (<a href="http://pdaps.org./datasets/laws-regulating-administration-of-naloxone-1501695139">http://pdaps.org./datasets/laws-regulating-administration-of-Naloxone-1501695139</a>).This dataset focuses on state laws that provide civil or criminal immunity to licensed healthcare providers or lay responders for opioid antagonist administration.</li> <li>This dataset is not quantitative, but a set of questions on the characteristics of the laws governing Naloxone accessibility to laypersons. I performed the following data preparation to allow for analysis and visualization:</li> <li><em>Naloxone accessibility law effectiveness calculation:Each question with a “Yes” answer adds one point to the law’s cumulative effectiveness score on the year it was implemented.</em></li> </ul> </li> </ul>
Opioid Analgesic Reduction Study
ClinicalTrials.gov study NCT04452344. IPD Sharing: YES. Countries: 1. Publications: 2.
Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
ClinicalTrials.gov study NCT06042816. IPD Sharing: YES. Countries: 1. Publications: 5.
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
ClinicalTrials.gov study NCT02469077. IPD Sharing: NO. Countries: 1. Publications: 29.
RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at th
ClinicalTrials.gov study NCT01809106. IPD Sharing: Not stated. Countries: 1. Publications: 7.
EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications
ClinicalTrials.gov study NCT03308188. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data for paper: Comparing Measures of Centrality in Bipartite Social Networks: A Study of Drug Seeking for Opioid Analgesics
<p>Data and code for paper: Comparing Measures of Centrality in Bipartite Social Networks: A Study of Drug Seeking for Opioid Analgesics</p>
Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.
ClinicalTrials.gov study NCT01882530. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment
ClinicalTrials.gov study NCT01326325. IPD Sharing: Not stated. Countries: 1. Publications: 34.
Analgesic Effects of Ultrasound Guided PEC Blocks on Analgesic Opioid Consumption of Cancer Surgery Patients
ClinicalTrials.gov study NCT02495363. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
ClinicalTrials.gov study NCT06949826. IPD Sharing: YES. Countries: 1. Publications: 32.
Suicidal Risk Factors Associated With Opioid Analgesics Use
ClinicalTrials.gov study NCT04211077. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid
ClinicalTrials.gov study NCT03156907. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Multimodal Analgesic Management of Naborphine Combined With Opioid Free Anesthesia in OSA Patients Undergoing Bariatric Surgery
ClinicalTrials.gov study NCT05386979. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy
ClinicalTrials.gov study NCT05024825. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Self-reported Usage Patterns of Opioid Analgesic Medications After Surgery
ClinicalTrials.gov study NCT03034278. IPD Sharing: NO. Countries: 1. Publications: 5.
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
ClinicalTrials.gov study NCT04003350. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evolution of Analgesic Tolerance With Opioids
ClinicalTrials.gov study NCT00275249. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of PENS of the Auricle as an Opioid Sparing Postoperative Analgesic Technique in Cancer Endometrium and Cancer Cervix Patients
ClinicalTrials.gov study NCT05742711. IPD Sharing: NO. Countries: 1. Publications: 2.
Improve Adherence to Weak or Strong Opioid Analgesics at the Time of Care in Children With Hereditary Epidermolysis Bullosa
ClinicalTrials.gov study NCT04853667. IPD Sharing: NO. Countries: 1. Publications: 0.
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