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7 results for “Orb2”
Data from: A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information
The regulation of mRNA translation at the level of the synapse is believed to be fundamental in memory and learning at cellular level. The family of Cytoplasmic Polyadenylation Element Binding (CPEB) proteins emerged as an important RNA binding protein family during development and in adult neurons. Drosophila Orb2 (homolog of mouse CPEB3 protein and of the neural isoform of Aplysia CPEB) has been found to be involved in the translation of plasticity-dependent mRNAs and has been associated to Long Term Memory. Orb2 protein presents two main isoforms, Orb2A and Orb2B, which form an activity induced amyloid-like functional aggregate, that is thought to be the translation-inducing state of the RNA binding protein. Here we present a first two-states continuous differential model for Orb2A-Orb2B aggregation. This model provides new working hypotheses for studying the role of prion-like CPEB proteins in long term synaptic plasticity. Moreover, this model can be used as a first step to integrate translation- and protein aggregation-dependent phenomena in synaptic facilitation rules.
Data from: A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information
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The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain
GEO Series GSE299140. Drosophila melanogaster. 18 samples. Type: Expression profiling by high throughput sequencing.
Effect of Orb2 depletion on mRNA expression in Drosophila larval brains
GEO Series GSE263513. Drosophila melanogaster. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-binding profiles of Drosophila CPEB proteins Orb and Orb2
GEO Series GSE59611. Drosophila melanogaster. 43 samples. Type: Expression profiling by high throughput sequencing; Other.
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain
GEO Series GSE299109. Drosophila melanogaster. 36 samples. Type: Expression profiling by high throughput sequencing.
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding 'ZZ' domain
GEO Series GSE299661. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
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