Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
3,029
datasets available to search
ShareScore release 0.9.0
Dataset results
3,029 results for “Osteoarthritis”
Patient reported outcome measures, load-induced blood marker kinetics, and ambulatory knee load in patients with medial compartment knee osteoarthritis
<p>The goal of this study was (i) to quantify the mechanoresponse of this array of potential blood markers for joint pathology (COMP, MMP-1, MMP-3, MMP-9, CPII, C2C, C2C/CPII, ADAMTS-4, PRG-4, IL-6 and resistin) to a walking stress test in patients with knee OA and to determine the correlation (ii) among the kinetics of these blood markers, (iii) with accumulated knee load during the walking stress, and (iv) with patient reported osteoarthritis outcome and QoL.</p> <p>The dataset includes 24 patients with knee osteoarthritis scheduled to receive high tibial osteotomy. All participants completed questionnaires, and a walking stress test with six blood samples analyzed using enzyme-linked immunosorbent assays for cartilage oligomeric matrix protein (COMP), matrix metalloproteinases (MMP)-1, -3, and -9, epitope resulting from cleavage of type II collagen by collagenases (C2C), type II procollagen (CPII), interleukin (IL)-6, proteoglycan (PRG)-4, A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, and resistin, and gait analysis. Joint load was computed from gait analysis data and musculoskeletal modelling in AnyBody Modeling System (AnyBody Technology A/S). Discrete loading parameters were extracted for each step using an inhouse algorithm written in Matlab.</p> <p>The detailed experimental protocol of the umbrella study has been described in Mündermann A, Vach W, Pagenstert G, Egloff C, Nüesch C. Assessing in vivo articular cartilage mechanosensitivity as outcome of high tibial osteotomy in patients with medial compartment osteoarthritis: Experimental protocol. Osteoarthr Cartil Open. 2020 Feb 24;2(2):100043. doi: 10.1016/j.ocarto.2020.100043. PMID: 36474590; PMCID: PMC9718245. The study is registered on clinicaltrials.gov (identifier NCT02622204). The method for computing joint loading has been described in detail in De Pieri E, Nüesch C, Pagenstert G, Viehweger E, Egloff C, Mündermann A. High tibial osteotomy effectively redistributes compressive knee loads during walking. J Orthop Res. 2022 Jun 22. doi: 10.1002/jor.25403. Epub ahead of print. PMID: 35730475.</p>
Safety and Efficacy of Mesenchymal Stromal Cells Mitochondria Transplantation as a Cell-Free Therapy for Osteoarthritis
<p><strong><span>Abstract</span></strong></p> <p><strong><span>Objective</span></strong></p> <p><span>The inflammatory responses from synovial fibroblasts and macrophages</span><span> and the mitochondrial dysfunction in chondrocytes<span> leading to oxidative stress, disrupt extracellular matrix (ECM) homeostasis</span> and accelerate the deterioration process of articular cartilage<span> in osteoarthritis (OA).<span> </span>In the last years, it has been proposed that mesenchymal stromal cells (MSC) transfer their functional mitochondria to damaged cells in response to cellular stress, becoming one of the mechanisms underpinning their therapeutic effects. </span>Therefore, we hypothesize that a novel cell-free treatment for OA could involve direct mitochondria transplantation, leading to the restoration of both cellular and mitochondrial homeostasis.</span></p> <p><strong><span>Methods</span></strong></p> <p><span>Mitochondria<span> were isolated from Umbilical Cord (UC)-MSC (Mito-MSC) and characterized based on their morphology, phenotype, functions, and their ability to be </span>internalized by <span>different articular cells. Furthermore, </span>the transcriptional changes following mitochondrial uptake by chondrocytes were evaluated using an Affymetrix analysis, Lastly, <span>the dose dependance therapeutic efficacy, biodistribution and immunogenicity of Mito-MSC w</span>ere assessed<span> in vivo, </span>through an intra-articular injection <span>in male C57BL6 mice in a </span>collagenase-induced OA <span>(CIOA) </span>model.</span></p> <p><strong><span>Results</span></strong></p> <p><span>Our findings demonstrate the functional integrity of Mito-MSC and their ability to be efficiently <span>transferred into chondrocytes, synovial macrophages, and synovial fibroblasts. </span>Moreover, the transcriptomic analysis showed the upregulation of genes involved in stress such as DNA reparative machinery and<span> inflammatory antiviral responses</span>.<span> </span>Finally, <span>Mito-MSC transplantation </span>yielded significant reductions<span> in joint mineralization, </span>a hallmark of OA progression<span>, </span>as well as improvements in OA-related histological signs, with the lower dose exhibiting better therapeutic efficacy. <span><span> </span></span>Furthermore, Mito-MSC were detected within the knee joint for up to 24 hours post-injection without eliciting an inflammatory response in CIOA mice. </span></p> <p><strong><span>Conclusion</span></strong></p> <p><span><span> </span>Collectively, our results reveal that mitochondria derived from MSC are transferred to key articular cells and are retained in the joint without generating an inflammatory immune response mitigating articular cartilage degradation in OA, probably through a restorative effect trigger by the stress antiviral response within OA chondrocytes.</span></p>
Supplementary table for "Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies"
Open the record for dataset details and reuse information.
Surface electromyography data set of knee osteoarthritis patients undergoing hydrotherapy and physiotherapy rehabilitation routines
<p>Osteoarthritis is one of the most prevalent degenerative diseases in the elderly that affects the structural and functional integrity of the musculoskeletal system. Currently, hydrotherapy is taking relevance for osteoarthritis treatment due to its possible efficacy on pain relief and functionality. This therapy can be evaluated by means of an electromyographic analysis. The objective is to show a database of lower limbs muscles electrical activity in charge of postural stability, comparing the difference between hydrotherapy and conventional therapy through surface electromyography. A signal acquisition methodology was developed measuring electromyographic activity of the Tibialis Anterior, Soleus, Vastus Medialis, Biceps Femoris, Medial Gastrocnemius and Lateral Gastrocnemius muscles, before and after applying a specific exercise routine for knee osteoarthritis. This routine consisted of 12 therapy sessions spread over 4 weeks and could be done in water and on land. </p> <p>The data is organized according to the attendance of 28 patients to the therapy sessions. There are two records per person, before and after each hydrotherapy or physiotherapy session, obtaining a total of 1344 records at the end of the 12 sessions, and 56 data for each session. However, a total of 864 complete records were obtained for both therapies, withdrawing those who missed any of the sessions. There is a personal information database in .CSV format and electromyographic records with a .MAT extension.</p>
FIG. 4 in Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
FIG. 4. — Évolution des assemblages de foraminifères benthiques et indications paléoenvironnementales dans le bassin du Bas Chélif (Algérie), coupe de Sassel plage. Abréviations: Bath., bathyal; Bri., Brizalina; Bo., Bolivina; Ci., Cibicides; Cibicidoi., Cibicidoides; Circa., circalittoral; Éch., échantillon; Form., formation; Fr., Fraction; Gyr., Gyroidina; Gyroidinoi., Gyroidinoides; Infra., infralittoral.
FIG. 6 in Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
FIG. 6. — Évolution des assemblages de foraminifères benthiques et indications paléoenvironnementales dans le bassin du Bas Chélif (Algérie), coupe de Sidi Brahim. Abréviations: Bath., bathyal; Bo., Bolivina; Bri., Brizalina; Ci., Cibicides; Cibicidoi., Cibicidoides; Circa., circalittoral; Éch., échantillon; Form., formation; Fr., Fraction; Globocas., Globocassidulina, Infra., infralittoral.
FIG. 3 in Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
FIG. 3. — Succession lithostratigraphique dans le bassin du Bas Chélif (Algérie): A, région de Sidi Bel Attar; B, région de Sidi Brahim.
FIG.1 in Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
FIG.1. — Situation géographique générale des régions et coupes étudiées, bassin du Bas Chélif (Algérie): 1, région de Aïn Temouchent, coupe de Sassel plage; 2, région de Mohammadia, coupe de Sahaouria; 3-4, région de Mostaganem; 3, coupe de Sidi Bel Attar; 4, coupe de Sidi Brahim. Abréviations: Dj., Djebel; O., oued.
FIG. 7 in Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
FIG. 7. — Corrélation biostratigraphique des terrains fini messinien-début pliocène dans le bassin du Bas Chélif (Algérie). 1, gypses; 2, marno-gréso-calcaire; 3, conglomérats; 4, marnes sableuses; 5, marnes; 6, calcaires à Halimeda; 7, Porites; 8, stromatolites; 9, marnes blanches (faciès Trubi); 10, grès.
3-D T1 relaxation time measurements in an equine model of subtle post-traumatic osteoarthritis using MB-SWIFT
<p>This dataset contains Key analysis and plotting scripts, data, and sample images.</p> <p>3-D T1 relaxation time measurements in equine model of post-traumatic osteoarthritis using MB-SWIFT</p> <p>Journal of Orthopaedic Research | DOI: 10.1002/jor.25629</p> <p>Swetha Pala (1), Nina Hänninen (1,2), Ali Mohammadi(1), Mohammadhossein Ebrahimi (1,2), Nikae C.R. te Moller(3), Harold Brommer(3), P. René van Weeren (3), Janne T.A. Mäkelä (1), Rami K. Korhonen (1), Isaac O. Afara(1), Juha Töyräs (1,4,5), Santtu Mikkonen (1), Mikko J. Nissi (1*), Olli Nykänen (1,2)</p> <p> 1Department of Applied Physics, University of Eastern Finland <br> 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu<br> 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University<br> 4Science Service Center, Kuopio University Hospital, Kuopio, Finland<br> 5School of Information Technology and Electrical Engineering, The University of Queensland </p> <p><br> *Corresponding author<br> Mikko J. Nissi<br> Department of Technical Physics<br> University of Eastern Finland, Kuopio Finland<br> POB 1627<br> 70211 Kuopio<br> mikko.nissi@uef.fi<br> +358-50-5955517<br> Running title: ‘3D T1 of mild PTOA using MB-SWIFT’</p> <p><br> Keywords: Quantitative MRI, T1 relaxation, equine model, post-traumatic osteoarthritis, proteoglycan content.</p> <p>Included folders and files are:<br> - Article_figures: all figures published in the manuscript (.svg format)<br> - Data: Raw MRI data files per flip angle (phase & magnitude images) from 28 samples and corresponding fitted T1 maps within respective folders. SPSS structured data files used for statistical analysis.<br> - Matlab scripts: Matlab functions used for data processing and T1 computation, aedes plugins, and data analysis with subfolders and files:<br> - aedes_plugins: plugins for aedes (http://aedes.uef.fi) and scripts for calculation of surface visualisations from relaxation time maps and auto-segmented mesh. <br> - Data processing and T1 computation: Scripts for non-linear 3D T1 fitting. <br> - Analysis: Key scripts used for analysis and plotting.</p> <p>- README.txt: this file describing the contents of the dataset.</p> <p><br> See more info in separate readme files included in sub-folders.</p> <p><br> (Swetha Pala, 31 May 2023)</p>
Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0
ClinicalTrials.gov study NCT05282927. IPD Sharing: YES. Countries: 1. Publications: 3.
Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion
ClinicalTrials.gov study NCT04906499. IPD Sharing: YES. Countries: 1. Publications: 26.
Randomized Study of the Efficacy and Safety of a Single Dose of Synvisc-One® in Chinese Patients With Symptomatic Osteoarthritis of the Knee
ClinicalTrials.gov study NCT03190369. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
ClinicalTrials.gov study NCT05025787. IPD Sharing: YES. Countries: 1. Publications: 58.
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT04864392. IPD Sharing: YES. Countries: 15. Publications: 1.
Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis.
ClinicalTrials.gov study NCT06622512. IPD Sharing: YES. Countries: 1. Publications: 13.
MicroCT Data of Mice for Osteoarthritis Biomarkers Project
<p>MicroCT data of mice for Quantitative Image-Based Osteoarthritis Bio-markers project. This dataset contains original data (ORIG- in filename of zipped folders containing DICOM files), manual segmentations (MAN- in filename), and automatic segmentations (AUTO- in filename) used for benchmarking of automated 3D bone characterization tools created by Kitware, Inc.</p> <p>Original data from: Lau AG (2014) Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement. <em>Haemophilia</em> 20(5):716-722. PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4396845/">PMC4396845</a>.</p> <p>Changes in version 1.0.1: Includes individual files for manual and automatic segmentations and corresponding original data in zipped folders. Version 1.0.0 contained a single zipped file with the entire dataset (MicroCT data mice osteoarthritis biomarkers.zip). See https://doi.org/10.5281/zenodo.3890144.</p>
Senescent preosteoclast secretome promotes metabolic syndrome-associated osteoarthritis through COX2-PGE2
<p><span>Metabolic syndrome–associated osteoarthritis (MetS-OA)</span><span> is a distinct osteoarthritis phenotype defined by the coexistence of MetS or its individual components. Despite the high prevalence of MetS-OA, its pathogenic mechanisms are unclear. Here, we report that humans and mice with MetS are more likely to develop osteoarthritis-related subchondral bone alterations than those without MetS. </span><span>MetS-OA mice exhibited</span><span> a rapid</span> <span>increase in joint </span><span>subchondral bone plate and trabecular thickness </span><span>before articular cartilage degeneration. Subchondral preosteoclasts undergo senescence </span><span>at the pre- or early</span><span>-osteoarthritis stage</span><span> and </span><span>acquire a unique secretome to</span><span> stimulate osteoblast differentiation and inhibit osteoclast differentiation. Antagonizing preosteoclast senescence markedly mitigates pathological subchondral alterations and osteoarthritis progression in MetS-OA mice. </span><span>At the molecular level,</span> <span>preosteoclast secretome activates </span><span>COX2-PGE2, resulting in stimulated differentiation of osteoblast progenitors for subchondral bone formation. Administration of a selective COX2 inhibitor attenuated subchondral bone alteration and osteoarthritis progression in MetS-OA mice. Longitudinal analyses of the human Osteoarthritis Initiative (OAI) cohort dataset also revealed that </span><span>COX2 inhibitor use, relative to non-selective nonsteroidal anti-inflammatory drug use</span><span>, is associated with less</span><span> progression of </span><span>osteoarthritis and subchondral bone marrow lesion worsening in participants with MetS-OA. Our findings suggest a central role of a senescent preosteoclast secretome-COX2/PGE2 axis in the pathogenesis of MetS-OA.</span></p>
Effect Of Pulsed Electromagnetic Field And Microwave Therapy On Pain And Physical Function In Older Adults With Knee Osteoarthritis: A Randomized Clinical Trial.
<p><strong><span>Background and purpose:</span></strong><span> </span><span>Pulsed electromagnetic field (PEMF) therapy and microwaves (MW) are two electrotherapy modalities that have shown to improve pain and function in patients with knee osteoarthritis (KOA). Nevertheless, the effectiveness of these therapies is controversial due to diversity in the application parameters and treatment protocols in these patients. The objective is to compare the effectiveness of active PEMF versus MW, as well as sham PEMF, in addressing pain and improving functionality for treating KOA.</span></p> <p><strong><span>Methods:</span></strong><span> </span><span>Double-blind, placebo-controlled, randomized clinical trial. Participants diagnosed with KOA were assigned to an intervention combining an exercise program with active PEMF, MW, or sham PEMF, delivered in three weekly sessions over four weeks. The main outcomes were pain, reported on a 0–10 cm visual analogue scale (VAS), and functionality, as evaluated with the Western Ontario and McMaster Universities Arthritis (WOMAC) questionnaire, and the Timed Up and Go test. The outcomes were measured at pre-intervention, immediately post-intervention, and one and four months after the intervention.</span></p>
Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady-state free precession in spontaneous human osteoarthritis
<div>This dataset contains key analysis and plotting scripts, data, and sample images.</div> <div> </div> <div>Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady-state free precession in spontaneous human osteoarthritis</div> <div> </div> <div>Magnetic Resonance in Medicine Journal | DOI: 10.1002/mrm.30206</div> <div> </div> <div>§ Swetha Pala(1), § Antti Paajanen(1), Aapo Ristaniemi(1), Ervin Nippolainen(1), Isaac O. Afara(1), Olli Nykänen (1), Mikko J. Nissi (1*)</div> <div> </div> <div>1Department of Technical Physics, University of Eastern Finland</div> <div>§Shared authorship </div> <div> </div> <div> </div> <div> </div> <div>*Corresponding author</div> <div>Mikko J. Nissi</div> <div>Department of Technical Physics</div> <div>University of Eastern Finland, Kuopio Finland</div> <div>POB 1627</div> <div>70211 Kuopio</div> <div>mikko.nissi@uef.fi</div> <div>+358-50-5955517</div> <div> </div> <div> </div> <div>Keywords: Quantitative MRI, T1ρ relaxation, T1ρ dispersion, Compressed-sensing, radial acquisition.</div> <div> </div> <div>Included folders and files are:</div> <div>- Article_figures: all figures published in the manuscript (.eps format)</div> <div>- Data: MRI data files from 27 human cadaver samples with subfolders and files:</div> <div>- Human samples data: raw data files, along with generic analysis ROIs, zone divison inside specific samples folder, and within the parameter related data folder there are smaple specific analysis ROIs, computed profiles per spin lock amplitude. </div> <div>- CS reconstructed data files: </div> <div>- DataTables_used_for_analysis: Contains data tables per AF and reference data used for data analysis </div> <div>- Scripts: Matlab functions used for data processing and T1ρ computation, aedes plugins, and data analysis with subfolders and files:</div> <div> - Aedes_plugins: Plugins for aedes (http://aedes.uef.fi) for calculation of profiles from ROI. </div> <div> - Data analysis: Key scripts used for analysis and plotting.</div> <div> - Common functions: Some common functions that are required by the scripts/plugins. </div> <div> </div> <div>- README.txt: this file describing the contents of the dataset.</div> <div> </div> <div> </div> <div>See more info in separate readme files included in sub-folders.</div> <div> </div> <div> </div> <div>(Swetha Pala, 02 July 2024)</div> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.