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52 results for “PP2A”
AlphaFold-Multimer (v3) model of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein.
<p>AlphaFold-Multimer (v3) model structure of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein. The protein sequences were obtained from UniProt:</p> <p>P67775 · PP2AA_HUMAN</p> <p>P30153 · 2AAA_HUMAN</p> <p>P63151 · 2ABA_HUMAN</p> <p>Q96E09 · PBIR1_HUMAN</p> <p>Coordinates are in mmCIF format. A PyMOL session file is included.</p> <p>Modeling was performed with AlphaFold-Multimer v3, downloaded from DeepMind's github. Structure prediction was performed without templates. The model was relaxed with Amber.</p> <p>FAM122A binds using a short linear motif (SLIM) (residues 84-89) first identified in RBL1 (p107) (Fowle et al., eLife, <a href="https://doi.org/10.7554/eLife.63181">https://doi.org/10.7554/eLife.63181</a> in the form of a short alpha helix (residues 84-92). This is followed by a long alpha helix (residues 96-122) which blocks access to the active site of the catalytic subunit. There are further contacts of FAM122A (residues 150-170) with one of the beta sheets of the B55alpha beta propeller domain. FAM122A regulates PP2A activity during the cell cycle.</p> <p> </p>
PP2A complex disruptor SET prompts widespread hyper-transcription of growth-essential genes in the pancreatic cancer cells
<p>Hyper-activation of the oncogenic transcription reflects the epigenetic plasticity of the cancer cells. SET was described as a nuclear factor that stimulated transcription from the chromatin template. However, the mechanisms of SET-dependent transcription are unknown. Here, we found that over-expression of SET and CDK9 induced very similar transcriptome signatures in multiple cancer cell lines. SET localized in the transcription start site (TSS)-proximal regions and supported the RNA transcription. SET specifically bound the PP2A-C subunit and induced PP2A-A subunit repulsion from the C subunit, which indicated the role of SET as a PP2A-A/C complex disruptor in the TSS-proximal regions. Through blocking PP2A activity, SET assisted CDK9 to maintain Pol II CTD phosphorylation and activated mRNA transcription. Our findings position SET as a key factor that modulates chromatin PP2A activity, promoting the oncogenic transcription in pancreatic cancer.</p>
Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100
ClinicalTrials.gov study NCT06065462. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PP2A complex disruptor SET prompts widespread hyper-transcription of growth-essential genes in the pancreatic cancer cells
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PP2A B''a and B''b regulation gene expression in dark to red transition in Arabidopsis thaliana.
GEO Series GSE174428. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 1]
GEO Series GSE38565. Saccharomyces cerevisiae. 16 samples. Type: Expression profiling by array.
The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 2]
GEO Series GSE42033. Saccharomyces cerevisiae; Saccharomyces cerevisiae W303. 8 samples. Type: Expression profiling by array.
AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration
GEO Series GSE283654. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The PP2A regulator IER5L supports prostate cancer progression
GEO Series GSE249359. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
A PP2A-Integrator complex fine-tunes transcription by opposing CDK9 [3UTR-seq]
GEO Series GSE163802. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
PP2A attenuates thoracic aneurysm and dissection in mouse models of Marfan syndrome [RNA-seq]
GEO Series GSE278185. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
PP2A dependent modulation of c-Myc and p21 leads to differentiation and cell cycle control in Acute Myeloid Leukemia
GEO Series GSE148018. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
PP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
GEO Series GSE236625. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of PP2A deficiency on gene expression in CD8+ T cells activation [bulkRNA-Seq]
GEO Series GSE283805. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The Greatwall-Endosulfine-PP2A/B55 pathway controls entry into quiescence by promoting translation of Elongator-tuneable transcripts
GEO Series GSE269854. Schizosaccharomyces pombe. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer
GEO Series GSE58008. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21
GEO Series GSE114288. Homo sapiens. 3 samples. Type: Expression profiling by array.
Carcinogen-induced tumours arise from Lgr5+ intestinal stem cells in pp2a-/- mice
GEO Series GSE120241. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
STRIPAK directs PP2A activity to promote oncogenic transformation
GEO Series GSE118272. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A PP2A-Integrator complex fine-tunes transcription by opposing CDK9 [4sU-seq]
GEO Series GSE163803. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.