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52 results for “Penicillium oxalicum”
Fig. 8 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 8. (A) The 3D structure and hydrogen bond interaction of compound 18 with FXR at the 50th ns MD stimulation. (B) The agonistic activity of compound 18 against the wild-type, mutant R341V, or S342V FXR. Data were shown as the mean ± SD, n = 4 (*p <0.05, **p <0.01, ***p <0.001 compared to the Ctrl group; #p <0.05, ##p <0.01, ###p <0.001 compared to the WT group).
Fig. 7 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 7. The RMSD (A) and RMSF (B) of compound 18 with FXR in 50 ns MD stimulation. (C) The volume of pock for a complex of compound 18 and FXR in 50 ns MD stimulation. (D–F) The energy of the complex (D), energy of contribution (E), and hydrogen bond number (F) of compound 18 with FXR in the 50 ns MD stimulation. (G) The distance of compound 18 with amino acid residues Val325, Met328, and Phe329. (H) The distance of compound 18 with amino acid residues Ser332 and Tyr369.
Fig. 5 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 5. (A) Effects of compound 18 (2 μM) towards FXR, SHP1, and BSEP mRNA levels. (B) Effects of compound 18 (2 μM) towards FXR, SHP1, FGF, and BSEP expression levels. (C) Quantitative analysis of FXR, SHP1, FGF, and BSEP expression levels. Data were shown as the mean ± SD, n = 3 (*p <0.05, **p <0.01, ***p <0.001 compared to the Ctrl group). CDCA (80 μM) was used as the positive control.
Fig. 4 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 4. Experimental and calculated ECD spectra of 1 (A) and 5–7 (B–D) at the CAM-B3LYP/def-tzvp level.
Fig. 5 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 5. Time course for the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. AA (3.50 mg/50 mL) was added to 2-day-old culture for the biotransformation.
Fig. 4 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 4. Time course of mycelial biomass (A) and the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. AA (3.50 mg/50 mL) was added to 2-day-old culture for the biotransformation. Data presented are the means ± SD of results from three independent experiments.
Fig. 7 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 7. Inhibitory effects of metabolite 4 (A) and 7 (B) on cell viability and LPSinduced nitrite production in RAW 264.7 cells. Normal cells were incubated for 24 h with metabolite 4 and 7 at indicated concentrations. Cells were pretreated with the indicated concentrations of metabolite 4 and 7 for 1 h followed by treatment with LPS (1.0 μg/mL). After 24 h of incubation, the amount of nitrite in the culture supernatants and cell viability were measured. Data presented are the means ± SD of results from three independent experiments (###p <0.001 versus untreated group; *p <0.05, **p <0.01 versus LPS treated group. The small letters indicate the significant difference (p <0.05) between groups).
Fig. 6 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 6. The nuclear translocation effect of compound 18 (2 μM) against FXR.
Fig. 1 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 1. Structures of compounds 1–25 isolated from P. oxalicum SL2.
Fig. 3 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 3. Selected NOESY correlations of compounds 1 and 8.
Fig. 2. Selected HMBC and 1H–1H in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 2. Selected HMBC and 1H–1H COSY correlations of compounds 1, 2, 5, and 8.
Fig. 3. Key NOSEY correlations for metabolites 1–4 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 3. Key NOSEY correlations for metabolites 1–4.
Fig. 2. Key HMBC and 1H-1H COSY correlations for metabolites 1–5 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 2. Key HMBC and 1H-1H COSY correlations for metabolites 1–5.
Fig. 1 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 1. Structures of artemisinic acid (AA) and its biotransformation metabolites 1–8.
Fig. 8 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.
Fig. 8. Proposed biotransformation process of artemisinic acid (AA) by Penicillium oxalicum B4.
Effect of deletion of PoxCxrC and overexpression of POX_f08097 in engineering strain Penicillium oxalicum TE4-10 at the transcriptional level
GEO Series GSE210161. Penicillium oxalicum. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of fungus Penicillium oxalicum and its laeA deletion strains in 24h and 60h
GEO Series GSE71287. Penicillium oxalicum. 4 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling analysis of fungus Penicillium oxalicum wild type strain and its Podot1 deletion strain.
GEO Series GSE136585. Penicillium oxalicum. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of gene POX07948 deletion on gene expression of Penicillium oxalicum
GEO Series GSE154710. Penicillium oxalicum. 6 samples. Type: Expression profiling by high throughput sequencing.
The effects of transcriptional activator engineering on the transcriptome of Penicillium oxalicum
GEO Series GSE162657. Penicillium oxalicum. 12 samples. Type: Expression profiling by high throughput sequencing.
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