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93 results for “Pheochromocytomas”
Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning
<p>RNA-sequencing counts data from omental adipose tissue from control individuals (C1-3) and patients with pheochromocytoma (P1-4) for whole genes (genes-counts.tsv) and individual isoforms (isoform-counts.tsv). Additional details regarding recruited individuals are available in the associated manuscript.</p> <p>Tissue fragments (~150 mg) of adipose biopsies from controls and pheochromocytoma patients were homogenized using a metal bead-based mechanical procedure in a TissueLyser® (QIAGEN, Düsseldorf, Germany). Total RNA was isolated from tissue homogenates using a NucleoSpin® RNA kit (Macherey-Nagel, Dueren, Germany) following the manufacturer’s protocol. mRNA was purified from 2 μg of total RNA using oligo-dT beads; it was then fragmented, retrotranscribed with random primers, and subjected to second-strand synthesis to create double-stranded cDNA fragments. Adaptor ligation, purification of 200-base pair cDNA fragments, amplification of the purified fragments, and library preparation were performed as previously reported by our laboratory. Before sequencing, the RNA integrity number (RIN) of each sample was determined using an Agilent Bioanalyzer 2100; samples with RIN ≥ 7.5 were used for RNA-sequencing. The cDNA library quality and quantity were further analyzed as previously described. Libraries yielding satisfactory results were sequenced on an Illumina HiSeq 2000 sequencer (DNAvision, Charleroi, Belgium). The average reads per sample was 45 million; this level of coverage was previously shown to provide sufficient sequencing depth for gene expression quantification and transcript detection. Quality control of reads was performed using FastQC (version 0.11.8; bioinformatics.babraham.ac.uk/projects/fastqc). Gene expression was quantified using Salmon version 1.1.0 with the additional parameters “– seqBias – gcBias – validateMappings”. GENCODE version 31 (GRCh38.p12) was used as the reference genome and indexed using default parameters; this resulted in 175,775 transcripts corresponding to 35,183 genes.</p>
Anesthetic management of a case of pheochromocytoma using bioreactance method with Cheetah-NICOM monitor
<p><strong>Pheochromocytoma is a rare neoplasm originating from the chromaffin cells of the adrenal gland. The number of diagnosed and excised adrenal lesions has steadily increased over the last few decades. Contemporarily, improved monitoring systems and therapeutic advances have reduced mortality associated with this disease. During surgery the anesthesiologist must be ready to face sudden hemodynamic, metabolic and electrolyte fluctuations due to the release of catecholamines. In this Case Report, we describe a particularly complex anesthesiologic management of a large secretory lesion by using Cheetah Non-Invasive Cardiac Output Monitor (Cheetah-NICOM monitor), non-invasive hemodynamic monitoring system. A 72-year-old female patient was subjected to adrenalctomy after a diagnosis of an adrenal mass (5 cm) compatible with pheochromocytoma (highlighted by metanephrine dosage). Patient reports recurrent episodes of hypertensive crisis, sweating and precordial pain and was also affected by Type 2 diabetes mellitus. Adrenal surgery for pheochromocytoma results in a significant increase in heart rate and peripheral vascular resistance, which should therefore be monitored to guide the infusion of medicinal products. Although a preoperative preparation with Alpha and beta blockers was carried out, high doses of short-lived beta-blockers and alphalytic and vasodilator were required during the intervention. This case report shows that Cheetah-NICOM monitor allowed us to manage prompty and optimally the catecholaminergic storm and the volemic filling obtaining a rapid postoperative recovery.</strong></p>
Cabozantinib S-malate in Treating Patients With Metastatic Pheochromocytomas or Paragangliomas That Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT02302833. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II Study of 131I- Metaiodobenzylguanidine (MIBG) for Treatment of Metastatic or Unresectable Pheochromocytoma and Related Tumors
ClinicalTrials.gov study NCT01413503. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase
ClinicalTrials.gov study NCT03165721. IPD Sharing: NO. Countries: 1. Publications: 1.
Preoperative Alpha Blockade for Pheochromocytoma
ClinicalTrials.gov study NCT03176693. IPD Sharing: NO. Countries: 1. Publications: 7.
Microenvironment characteristics and molecular classification in pheochromocytoma patients
<p>Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells in the adrenal gland. However, the cellular molecular characteristics and immune microenvironment of PCCs are incompletely understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on 16 tissues from 4 sporadic unclassified PCC patients and 1 hereditary PCC patient with Von Hippel-Lindau (VHL) syndrome. We found that intra-tumoral heterogeneity was less extensive than the inter-individual heterogeneity of PCCs. Further, the unclassified PCC patients were divided into two types, metabolism-type (marked by NDUFA4L2 and COX4I2) and kinase-type (marked by RET and PNMT), validated by immunohistochemical staining. Trajectory analysis of tumor evolution revealed that metabolism-type PCC cells display phenotype of consistently active metabolism and increased metastasis potential, while kinase-type PCC cells showed decreased epinephrine synthesis and neuron-like phenotypes. Cell-cell communication analysis showed activation of the annexin pathway and a strong inflammation reaction in metabolism-type PCCs and activation of FGF signaling in the kinase-type PCC. Although multispectral immunofluorescence staining showed a lack of CD8<sup>+</sup> T cell infiltration in both metabolism-type and kinase-type PCCs, only the kinase-type PCC exhibited downregulation of <em>HLA-Ⅰ</em> molecules that possibly regulated by <em>RET</em>, suggesting the potential of combined therapy with kinase inhibitors and immunotherapy for kinase-type PCCs; in contrast, the application of immunotherapy to metabolism-type PCCs (with antigen presentation ability) is likely unsuitable. Our study presents a single-cell transcriptomics-based molecular classification and microenvironment characterization of PCCs, providing clues for potential therapeutic strategies to treat PCCs.</p>
Cardiac and Vascular Changes in Pheochromocytoma and Paraganglioma
ClinicalTrials.gov study NCT05082311. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
131MIBG to Treat Malignant Pheochromocytoma
ClinicalTrials.gov study NCT00028106. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)
ClinicalTrials.gov study NCT06440122. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
ClinicalTrials.gov study NCT07316075. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Feasibility of 123I-IBZM Scintigraphy (a D2 Agonist) in Patients With Pheochromocytoma (PHEO) and/or Paraganglioma (PGL) : Study Pilot
ClinicalTrials.gov study NCT00875407. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Development of a Tele-monitoring Program for Patients Undergoing Surgery for Pheochromocytoma and / or Paraganglioma
ClinicalTrials.gov study NCT04573816. IPD Sharing: YES. Countries: 1. Publications: 2.
Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma
ClinicalTrials.gov study NCT06062082. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma
ClinicalTrials.gov study NCT01371201. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Diagnosis of Pheochromocytoma
ClinicalTrials.gov study NCT00004847. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
ClinicalTrials.gov study NCT03206060. IPD Sharing: YES. Countries: 1. Publications: 6.
Hereditary Pheochromocytoma Assessment of Tumour Immunologies
ClinicalTrials.gov study NCT06444607. IPD Sharing: YES. Countries: 1. Publications: 7.
The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma
ClinicalTrials.gov study NCT05702944. IPD Sharing: NO. Countries: 1. Publications: 15.
Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
ClinicalTrials.gov study NCT03160274. IPD Sharing: NO. Countries: 1. Publications: 1.
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