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18 results for “Piezo2”
Piezo2 in bladder-innervating sensory neurons contributes to regulation of contractile activity in cystitis
<p>Overactivity of the urinary bladder constitutes one of the main symptoms in various lower urinary tract disorders and it significantly deteriorates quality of life. The crucial role of mechanotransduction in bladder-innervating unmyelinated C-type primary sensory nerve fibres in initiating the voiding reflex in the overactive bladder has been well established. However, the molecular identity of the mechanotransducer(s) in bladder-innervating C-type sensory neurons is still elusive. The mechanosensitive ion channel Piezo2 in primary sensory neurons has been implicated in various physiological and pathological functions including proprioception, the detection of low and high threshold mechanical stimuli in the skin, and the development of mechanical hypersensitivity in peripheral pathologies. Here, we investigated whether or not Piezo2 expressed in primary sensory neurons could contribute to bladder overactivity in cystitis. Characterisation of Piezo2 expression revealed that about 1/5 of primary sensory neurons express this ion channel and at least half of the Piezo2-expressing cells express various markers for unmyelinated C-type sensory neurons. Further, we found that Piezo2 is expressed predominantly in lamina I and II of the spinal cord, where C-type sensory neurons terminate. We disclosed that Piezo2 is expressed in sensory neuron terminals innervating peripheral tissues including the bladder wall and noxious but not innocuous pressure in the urinary bladder activates Piezo2-expressing primary sensory neurons. Finally, we show that instillation of GsMTx that blocks Piezo2 significantly reduces overactivity in the inflamed but not in the naive urinary bladder. Together these findings indicate that Piezo2 in bladder-innervating unmyelinated C-type neurons contributes to the detection of noxious pressure and regulation of contractile activity in cystitis.</p>
Piezo2 and perineal mechanosensation are essential for sexual function
<p>Despite the potential importance of genital mechanosensation for sexual reproduction little is known about how perineal touch influences mating. Here we explored how mechanosensation affords exquisite awareness of the genitals and controls reproduction in mice and humans. Using genetic strategies and in vivo functional imaging, we demonstrated that the mechanosensitive ion channel Piezo2 is necessary for behavioral sensitivity to perineal touch. Notably, Piezo2-function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration. Together, our results explain how perineal mechanoreceptors detect the gentlest of stimuli and trigger physiologically important sexual responses, providing a platform for exploring the sensory basis of sexual pleasure and its relationship to affective touch.</p>
Piezo2 and perineal mechanosensation are essential for sexual function
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Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"
<p>Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"</p>
Supplementary files for the article entitled: PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway
<p>All results were analyzed using the Statistical Package for the Social Sciences version 20.0 (IBM Corporation, Armonk, NY, USA). The results of Schoenfeld residuals method were analyzed using the R 4.2.2 software and survminer package.</p>
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene
ClinicalTrials.gov study NCT06052631. IPD Sharing: NO. Countries: 1. Publications: 34.
Piezo2-related Arthrogryposis & physiopathOLOgy 3
ClinicalTrials.gov study NCT07360574. IPD Sharing: NO. Countries: 1. Publications: 8.
Fibroblasts expressing PIEZO2 mechanoreceptor in keloids possibly cause alloknesis and short-term recurrence after surgical resection [RNA-seq]
GEO Series GSE266338. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Fibroblasts expressing PIEZO2 mechanoreceptor in keloids possibly cause alloknesis and short-term recurrence after surgical resection [scRNA-seq]
GEO Series GSE266334. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation [scRNA-seq]
GEO Series GSE286425. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing of dorsal root ganglia (DRG) in Cdx2-Cre; Piezo2 conditional mutants and control littermates, age P21-P24
GEO Series GSE254789. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
PIEZO2 mechanoreceptor-expressing fibroblasts in keloids cause short-term recurrence after surgical resection
GEO Series GSE274709. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism
GEO Series GSE256369. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation [bulk RNA-seq]
GEO Series GSE286424. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
Piezo2 promotes resistance to radiation by suppressing CD8+ T cell-mediated antitumor immunity via IRF-1/IL-15 signaling
GEO Series GSE236346. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance
GEO Series GSE236345. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance
GEO Series GSE236339. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Maturational changes in mouse cutaneous touch and Piezo2-mediated mechanotransduction
GEO Series GSE154161. Mus musculus. 49 samples. Type: Expression profiling by high throughput sequencing.
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