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818 results for “Placenta”
iPlacenta: hIPSC placenta-on-a-chip RNAseq data from 3D vs 2D, day 0 vs day 4 differentiation
<p>RNAseq data from hIPSC dervived trophoblasts seeded in 3D (OrganoPlate) or 2D surface at day 0 or day 4 differentiation. </p> <p>Description of file names found below</p> <table> <tbody> <tr> <td> <p><strong>SampleID/File name</strong></p> </td> <td> <p><strong>Condition- Differentiation day</strong></p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D0-1</p> </td> <td> <p>2D-Day0</p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D0-2</p> </td> <td> <p>2D-Day0</p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D0-3</p> </td> <td> <p>2D-Day0</p> </td> </tr> <tr> <td> <p> </p> </td> <td> <p> </p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D4-4</p> </td> <td> <p>2D-Day4</p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D4-5</p> </td> <td> <p>2D-Day4</p> </td> </tr> <tr> <td> <p>iPSC-THB-2D-D4-6</p> </td> <td> <p>2D-Day4</p> </td> </tr> <tr> <td> <p> </p> </td> <td> <p> </p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D0-7</p> </td> <td> <p>3D-Day0</p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D0-8</p> </td> <td> <p>3D-Day0</p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D0-9</p> </td> <td> <p>3D-Day0</p> </td> </tr> <tr> <td> <p> </p> </td> <td> <p> </p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D4-10</p> </td> <td> <p>3D-Day4</p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D4-11</p> </td> <td> <p>3D-Day4</p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D4-12</p> </td> <td> <p>3D-Day4</p> </td> </tr> <tr> <td> <p>iPSC-THB-3D-D4-13</p> </td> <td> <p>3D-Day4</p> </td> </tr> </tbody> </table>
Inter-Chemical Correlation results for the study: HHEARx2017-1729 (Air Pollution, Placenta Function, and Birth Outcomes in Los Angeles)
Title: Air Pollution, Placenta Function, and Birth Outcomes in Los Angeles <br>Species: Homo sapiens <br>Number of samples: 450 <br>Number of named analytes: 14 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=48 <br>
Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy - IHC data
<p>SARS-CoV-2 infection during pregnancy does not affect the large majority of neonates but presents an increased risk for adverse pregnancy outcome. The effects of SARS-CoV-2 of its recently identified variants on placental function are not well understood. In this study, we investigated the impact of late gestational SARS-CoV-2 infection on the placenta.</p> <p>This dataset of is comprised of 897 images of classic immunohistochemistry for 3 markers in placenta from COVID-19 patients and controls.</p> <p><strong>A full description of the tissues, markers, and donors is available in the metadata.csv file.</strong></p>
Predicting placenta transcriptional regulatory interactions based on spatial gene expression data and convolutional neural network
<p><strong>Aims:</strong> The dysfunction of placenta development is correlated to the defects of pregnancy and fetal growth. The detailed molecular mechanism of placenta development is not identified in human due to the lack of material in vivo. Image-based reconstructions of GRN are still very underdeveloped.</p> <p><strong>Methods and Results:</strong> In this study, first-trimester chorionic villus and decidua tissues were collected. Next, we present a machine-learning system to infer gene interaction networks of the human placenta from immunofluorescence images of trophoblast specific transcription factors obtained by a high-resolution scanner.</p> <p><strong>Conclusions:</strong> The experimental results show that deep learning models reveal regulatory roles that have not yet been fully recognized. The spatial expression data reveal new regulatory relationships that traditional experiments have failed to recognize, and has allowed the development of gene regulation networks based on the spatial distribution of gene expression. We demonstrate the effectiveness of this approach in building networks using high-resolution images of the human placenta. Our analysis is of certain significance for further exploration of the development of the placenta and the occurrence of pregnancy-related diseases in the future. The datasets and analysis provide a useful source for the researchers in the field of the maternal-fetal interface and the establishment of pregnancy.</p>
OMAP-8: Multiplexed Antibody-Based Imaging of Placenta with Imaging Mass Cytometry (IMC), v1.0
<p>OMAP-8 was designed for Imaging Mass Cytometry (IMC) (<a href="https://pubmed.ncbi.nlm.nih.gov/24584193/">https://pubmed.ncbi.nlm.nih.gov/24584193/</a>) of formalin-fixed paraffin-embedded (FFPE) human term-placenta samples. The tissue slides were prepared with a two-step antigen retrieval process (pH 6 and pH 9, as described <a href="https://dx.doi.org/10.17504/protocols.io.bpwumpew">https://dx.doi.org/10.17504/protocols.io.bpwumpew</a>). OMAP antibodies validated by immunohistochemistry and IMC were conjugated to polymers containing metal isotopes. Conjugated antibodies were used to stain processed human term-placenta tissue simultaneously. Regions of the processed tissue were then acquired on the imaging mass cytometer (Hyperion; Standard BioTools) by laser ablation and visualized. The panel contains 26 antibodies conjugated to unique metal isotopes and iridium marks the DNA. This OMAP provides a spatial context for key placenta cell types in the <a href="https://doi.org/10.48539/HBM446.WGLG.755">ASCT+B v.1.0 table</a>. Single-cell RNA sequencing data were used to guide marker selection for multiplexed tissue imaging. For example, ASCL2, HLA-G, PD-L1, CD68 and LYVE1 allow functionally specialized cell types to be visualized and quantified in the placenta. Note that one of our core antibodies is to LYVE1 but, unlike in other tissues where it is used to mark lymphatic vasculature, here we use it to mark the macrophage of the placenta (Hofbauer cells) – there should be no lymphatics in the placenta.</p>
Progressive degradation of acetylated wood by the brown rot fungi Coniophora puteana and Rhodonia placenta
<p>This dataset contains measurement data from the following publication: Belt, T.; Awais, M. (2025) Progressive degradation of acetylated wood by the brown rot fungi <em>Coniophora puteana</em> and <em>Rhodonia placenta</em>. Wood Science and Technology 59:13. https://doi.org/10.1007/s00226-024-01620-8. The experimental methods are described in brief below; further details can be found in the publication.</p> <p>Scots pine sapwood samples were acetylated in neat acetic anhydride to 9% or 18% weight percent gain (WPG) or left untreated to act as reference. The samples were exposed to brown rot decay in a stacked-sample decay test conducted in test tubes. Each replicate tube received 6 reference or acetylated samples stacked on top of each other (sample positions 1-6 from top to bottom) over nutrient agar inoculated with <em>Coniophora puteana</em> (N = 7) or <em>Rhodonia placenta</em> (N = 5). The different wood-fungus combinations were incubated for different durations until the visible fungal mycelium reached the top of the topmost block in one replicate tube. The samples were weighed before modification, after modification, at the end of the decay test, and after the decay test to determine their WPG, moisture content at the end of the decay test, and mass loss due to decay. After decay, 15 samples from every wood-fungus combination were selected for acetyl content measurement and FTIR spectroscopy.</p> <p>Acetyl contents were measured on powdered samples by saponification followed by HPLC quantification of the liberated acetic acid. FTIR spectra were measured in the 400-4000 cm<sup>-1</sup> spectral range in triplicate on powdered samples using an ATR accessory. For further analysis, the spectra were cut to 800-1800 cm<sup>-1</sup> range, baseline corrected (third degree polynomial subtraction), smoothed (Savitzky-Golay procedure with a second-order polynomial and a 15-point window), and normalised (unit vector normalisation).</p> <p>The "Mass data and acetyl content.csv" -file gives the sample identifiers (ID, sample type, test fungus, tube number, sample position) and measured mass data of all samples, and the acetyl contents of the selected samples. Masses m<sub>init</sub>, m<sub>mod</sub>, m<sub>wet</sub>, and m<sub>dec</sub> are the initial unmodified dry mass, the modified dry mass, the decaying wet mass, and the decayed dry mass, respectively. Acetyl contents (%) are given on a decayed wood basis.</p> <p>The “Unprocessed FTIR spectra_reference”, “Unprocessed FTIR spectra_9%”, and “Unprocessed FTIR spectra_18%” -files contain the unprocessed FTIR spectra of the reference, 9% WPG and 18% WPG samples (see the "Mass data and acetyl content.csv" -file for sample identifiers). The “Preprocessed FTIR spectra_reference”, “Preprocessed FTIR spectra_9%”, and “Preprocessed FTIR spectra_18%” -files in turn contain the preprocessed FTIR spectra of reference, 9% WPG and 18% WPG samples.</p>
Different genes are recruited during convergent evolution of pregnancy and the placenta
<p>The repeated evolution of the same traits in distantly related groups (convergent evolution) raises a key question in evolutionary biology: do the same genes underpin convergent phenotypes? Here, we explore one such trait, viviparity (live birth), which, qualitative studies suggest, may indeed have evolved via genetic convergence. There are 150 independent origins of live birth in vertebrates, providing a uniquely powerful system to test the mechanisms underpinning convergence in morphology, physiology, and/or gene recruitment during pregnancy. We compared transcriptomic data from eight vertebrates (lizards, mammals, sharks) that gestate embryos within the uterus. Since many previous studies detected qualitative similarities in gene use during independent origins of pregnancy, we expected to find significant overlap in gene use in viviparous taxa. However, we found no more overlap in uterine gene expression associated with viviparity than we would expect by chance alone. Each viviparous lineage exhibits the same core set of uterine physiological functions. Yet, contrary to prevailing assumptions about this trait, we find that none of the same genes are differentially expressed in all viviparous lineages, or even in all viviparous amniote lineages. Therefore, across distantly related vertebrates, different genes have been recruited to support the morphological and physiological changes required for successful pregnancy. We conclude that redundancies in gene function have enabled the repeated evolution of viviparity through recruitment of different genes from genomic "toolboxes", which are uniquely constrained by the ancestries of each lineage.</p>
Text-fig. 8. SEM (a, b) and SRXTM (c, d) images of fruit associated with Miranthus elegans and Miranthus kvacekii; Mira locality, Portugal. a: Apical view of capsular fruit with five, partly open valves revealing the enclosed reticulate seeds (arrows). b: Detail of fruit wall showing an enclosed seed (arrow). c: Transverse section (orthoslice xy1200) of fruit showing central column (cc) of placenta and numerous angular and bitegmic seeds; note that the outer integument (black arrow) is thicker than inner integument (white arrow). d: Longitudinal section (orthoslice yz1239) of fruit showing perigynous attachment of calyx, central column (cc) of the placenta and sections through seeds. Specimen, Mira 99-S156331 (a–d). Scale bars = 600 µm (a, c, d), 200 µm (b). in Early Flowers Of Primuloid Ericales From The Late Cretaceous Of Portugal And Their Ecological And Phytogeographic Implications
Text-fig. 8. SEM (a, b) and SRXTM (c, d) images of fruit associated with Miranthus elegans and Miranthus kvacekii; Mira locality, Portugal. a: Apical view of capsular fruit with five, partly open valves revealing the enclosed reticulate seeds (arrows). b: Detail of fruit wall showing an enclosed seed (arrow). c: Transverse section (orthoslice xy1200) of fruit showing central column (cc) of placenta and numerous angular and bitegmic seeds; note that the outer integument (black arrow) is thicker than inner integument (white arrow). d: Longitudinal section (orthoslice yz1239) of fruit showing perigynous attachment of calyx, central column (cc) of the placenta and sections through seeds. Specimen, Mira 99-S156331 (a–d). Scale bars = 600 µm (a, c, d), 200 µm (b).
Text-fig. 5. SRXTM images of Miranthus elegans gen. et sp. nov.; Mira locality, Portugal. a, b: Transverse sections of flower (a, orthoslice xy0665 close to the apex of placenta; b, orthoslice xy0800 in middle part of placenta) showing remains of calyx with distinct bundles (arrows), ovary wall (ow) and numerous ovules (ov) on the central mushroom-shaped globose placenta (pl) with central column (cc). c: Transverse section of flower (orthoslice xy0620) through perianth and ovary (ow) at a level above the placenta showing ovules (ov) and cellular preservation of the sepal bundles (arrows shown for one sepal); note abaxial surface of sepals with thick-walled epidermal cells, thick cuticle, and fine pointed verrucae. d: Longitudinal section of flower (orthoslice xz0500) showing perigynous position of calyx and semi-inferior ovary (ow, ovary wall) with a central placenta (pl), central column (cc) and numerous ovules (ov); note spiny verrucae on abaxial surface of calyx lobes. Specimens, Mira 100-S153145 (a, b), Mira 100-S170155 (c, d, holotype). Scale bars = 600 µm (a–d). in Early Flowers Of Primuloid Ericales From The Late Cretaceous Of Portugal And Their Ecological And Phytogeographic Implications
Text-fig. 5. SRXTM images of Miranthus elegans gen. et sp. nov.; Mira locality, Portugal. a, b: Transverse sections of flower (a, orthoslice xy0665 close to the apex of placenta; b, orthoslice xy0800 in middle part of placenta) showing remains of calyx with distinct bundles (arrows), ovary wall (ow) and numerous ovules (ov) on the central mushroom-shaped globose placenta (pl) with central column (cc). c: Transverse section of flower (orthoslice xy0620) through perianth and ovary (ow) at a level above the placenta showing ovules (ov) and cellular preservation of the sepal bundles (arrows shown for one sepal); note abaxial surface of sepals with thick-walled epidermal cells, thick cuticle, and fine pointed verrucae. d: Longitudinal section of flower (orthoslice xz0500) showing perigynous position of calyx and semi-inferior ovary (ow, ovary wall) with a central placenta (pl), central column (cc) and numerous ovules (ov); note spiny verrucae on abaxial surface of calyx lobes. Specimens, Mira 100-S153145 (a, b), Mira 100-S170155 (c, d, holotype). Scale bars = 600 µm (a–d).
Text-fig. 7. SEM (a) and SRXTM (b–e) images of Miranthus kvacekii sp. nov.; Mira locality, Portugal. a: Lateral view of flower bud showing corolla lobes extending beyond calyx; note surface of pedicel, calyx and corolla with small equiaxial epidermal cells and indumentum of densely spaced, short stiff trichomes. b, c: Longitudinal sections through floral bud in two directions perpendicular to each other (a, orthoslice yz1024; b, orthoslice xz0950) showing corolla (co), calyx (ca), stamens (st) and semi-inferior ovary with thin ovary wall (ow) and central mushroom-shaped globose placenta (pl) bearing numerous ovules (ov). d, e: Transverse sections through floral bud above placenta (d, orthoslice xy0915; e, orthoslice xy1095) showing calyx (ca), corolla (co), ovary wall (ow) and ovules (ov); yellow outlines indicate the positions of anthers (d) and filaments (e); orange outlines indicate the position of three of the possible staminodes. Specimen, Mira 100-S170157 (a–e, holotype). Scale bars = 600 µm (a–c), 300 µm (d, e). in Early Flowers Of Primuloid Ericales From The Late Cretaceous Of Portugal And Their Ecological And Phytogeographic Implications
Text-fig. 7. SEM (a) and SRXTM (b–e) images of Miranthus kvacekii sp. nov.; Mira locality, Portugal. a: Lateral view of flower bud showing corolla lobes extending beyond calyx; note surface of pedicel, calyx and corolla with small equiaxial epidermal cells and indumentum of densely spaced, short stiff trichomes. b, c: Longitudinal sections through floral bud in two directions perpendicular to each other (a, orthoslice yz1024; b, orthoslice xz0950) showing corolla (co), calyx (ca), stamens (st) and semi-inferior ovary with thin ovary wall (ow) and central mushroom-shaped globose placenta (pl) bearing numerous ovules (ov). d, e: Transverse sections through floral bud above placenta (d, orthoslice xy0915; e, orthoslice xy1095) showing calyx (ca), corolla (co), ovary wall (ow) and ovules (ov); yellow outlines indicate the positions of anthers (d) and filaments (e); orange outlines indicate the position of three of the possible staminodes. Specimen, Mira 100-S170157 (a–e, holotype). Scale bars = 600 µm (a–c), 300 µm (d, e).
Text-fig. 2. SEM images of Miranthus elegans gen. et sp. nov.; Mira locality, Portugal. a, b: Flowers in oblique lateral view showing remains of calyx and slightly semi-inferior ovary with elongated apical style (a); note larger openings in the floral tissue (asterisk) interpreted as schizogenous secretory cavities and the stomata-like secretory structures on the upper portion of the ovary (arrows) that are interpreted as nectariferous (b). c: Detail of ovary surface showing secretory stomata-like structures (arrows). d: Flower in lateral view showing fragmentary calyx and broken slightly semi-inferior ovary with secretory stomata-like structures; note the point of attachment of the central placenta (pl). e: Cluster of seeds removed from the ovary in (d) showing reticulate surface. f: Outer (abaxial) surface of calyx lobe showing the slightly pointed papillae and scattered, fine trichomes (arrows). g: Triaperturate pollen grains from the ovary surface. Specimens, Mira 100-S153146 (a, b), Mira 100-S170155 (c), Mira 100-S101266 (d, e), Mira 105-S100732 (f), Mira 100-S170125 (g). Scale bars = 600 µm (a, b, d), 300 µm (f), 100 µm (c, e), 10 µm (g). in Early Flowers Of Primuloid Ericales From The Late Cretaceous Of Portugal And Their Ecological And Phytogeographic Implications
Text-fig. 2. SEM images of Miranthus elegans gen. et sp. nov.; Mira locality, Portugal. a, b: Flowers in oblique lateral view showing remains of calyx and slightly semi-inferior ovary with elongated apical style (a); note larger openings in the floral tissue (asterisk) interpreted as schizogenous secretory cavities and the stomata-like secretory structures on the upper portion of the ovary (arrows) that are interpreted as nectariferous (b). c: Detail of ovary surface showing secretory stomata-like structures (arrows). d: Flower in lateral view showing fragmentary calyx and broken slightly semi-inferior ovary with secretory stomata-like structures; note the point of attachment of the central placenta (pl). e: Cluster of seeds removed from the ovary in (d) showing reticulate surface. f: Outer (abaxial) surface of calyx lobe showing the slightly pointed papillae and scattered, fine trichomes (arrows). g: Triaperturate pollen grains from the ovary surface. Specimens, Mira 100-S153146 (a, b), Mira 100-S170155 (c), Mira 100-S101266 (d, e), Mira 105-S100732 (f), Mira 100-S170125 (g). Scale bars = 600 µm (a, b, d), 300 µm (f), 100 µm (c, e), 10 µm (g).
Text-fig. 43. Synchrotron radiation X-ray tomographic microscopy SRXTM images of "Tricarpellate flower sp. 2"; Catefica locality, Portugal. a) Lateral view of floral structure (volume rendering) showing the apical projection of the carpels and the semiinferior organization; b) Apical view of floral structure (volume rendering) showing the triangular shape of the hypanthial rim, the tricarpellate ovary with a single apical style; note that one locule is fully developed while the other two are collapsed; note also slits of unknown nature in the corners of the triangular hypanthial rim (arrows); c) Transverse section (orthoslice xy0712) close to the floral apex showing the locule of the one fully developed carpel with ovules borne along ventral placentae; note amorphous substance (asterisk) associated with the developing ovules that fills part of the locule space; d) Longitudinal section (orthoslice xz0858) through the locule of the one fully developed carpel showing the semi-inferior organization and ovules arranged along the full length of the carpel; note amorphous substance (asterisk) associated with the developing ovules that fills part of the locule space; e) Tangential longitudinal section (orthoslice yz1019) through the one fully developed locule, showing the densely packed ovules and the amorphous substance (asterisk) with which they are associated. Specimen, Catefica 50-S174901 (a–e). Scale bars = 300 Μm (a–e). in The Early Cretaceous Mesofossil Flora Of Catefica, Portugal: Angiosperms
Text-fig. 43. Synchrotron radiation X-ray tomographic microscopy SRXTM images of "Tricarpellate flower sp. 2"; Catefica locality, Portugal. a) Lateral view of floral structure (volume rendering) showing the apical projection of the carpels and the semiinferior organization; b) Apical view of floral structure (volume rendering) showing the triangular shape of the hypanthial rim, the tricarpellate ovary with a single apical style; note that one locule is fully developed while the other two are collapsed; note also slits of unknown nature in the corners of the triangular hypanthial rim (arrows); c) Transverse section (orthoslice xy0712) close to the floral apex showing the locule of the one fully developed carpel with ovules borne along ventral placentae; note amorphous substance (asterisk) associated with the developing ovules that fills part of the locule space; d) Longitudinal section (orthoslice xz0858) through the locule of the one fully developed carpel showing the semi-inferior organization and ovules arranged along the full length of the carpel; note amorphous substance (asterisk) associated with the developing ovules that fills part of the locule space; e) Tangential longitudinal section (orthoslice yz1019) through the one fully developed locule, showing the densely packed ovules and the amorphous substance (asterisk) with which they are associated. Specimen, Catefica 50-S174901 (a–e). Scale bars = 300 Μm (a–e).
Dataset placenta
<p>The dataset comprises placental parameter Diameter 2 and its corresponding gestational age for the Portuguese population. It encompasses a time range from 12 to 41 weeks, providing valuable insights into the development of placental Diameter 2 throughout various stages of pregnancy.</p>
Different genes are recruited during convergent evolution of pregnancy and the placenta
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Data from: The evolution of a placenta accelerates the evolution of post-copulatory reproductive isolation
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The oxytocin-prostaglandins pathways in the horse (Equus caballus) placenta during pregnancy, physiological parturition, and parturition with fetal membrane retention
<p>Despite their importance in mammalian reproduction, substances in the oxytocin-prostaglandins pathways have not been investigated in the horse placenta during most of pregnancy and parturition. Therefore, we quantified placental content of oxytocin (OXT), oxytocin receptor (OXTR), and prostaglandin E2 and F2 alpha during days 90–240 of pregnancy (PREG), physiological parturition (PHYS), and parturition with fetal membrane retention (FMR) in heavy draft horses (PREG = 13, PHYS = 11, FMR = 10). We also quantified <i>OXTR</i> and<i> </i>prostaglandin endoperoxide synthase-2 (<i>PTGS2</i>) mRNA expression and determined the immunolocalization of OXT, OXTR, and PTGS2. For relative quantification of OXT and OXTR, we used western blotting with densitometry. To quantify the prostaglandins, we used enzyme immunoassays. For relative quantification of <i>OXTR</i> and <i>PTGS2</i>, we used RT-qPCR. For immunolocalization of OXT, OXTR, and PTGS2, we used immunohistochemistry. We found that OXT was present in cells of the allantochorion and endometrium in all groups. <i>PTGS2</i> expression in the allantochorion was 14.7-fold lower in FMR than in PHYS (<i>p</i> = 0.007). These results suggest that OXT is synthesized in the horse placenta. As PTGS2 synthesis is induced by inflammation, they also suggest that FMR in heavy draft horses may be associated with dysregulation of inflammatory processes.</p>
Integrated and annotated human placenta scRNA-seq matrices
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Spatial multiomic landscape of the human placenta at molecular resolution
<p>Successful pregnancy and healthy human embryo development rely directly on the placenta’s complex, dynamic gene regulatory networks, both within placental subtypes and at the maternal-fetal interface (MFI), that underlie stemness, proliferation, differentiation, invasion, immune tolerance, and communication. These cellular and molecular mechanisms are notoriously challenging to elucidate and make this organ arguably the least understood in the human body. Additionally, disruption of this vast collection of intercellular and intracellular programs and pathways leads to pregnancy complications and developmental defects. Here, we generated a comprehensive spatially resolved multi-modal cell census elucidating the molecular architecture of the first trimester human placenta. We utilized paired single-cell ATAC and RNA sequencing, spatial single-cell ATAC and RNA sequencing (Slide-tags), and in situ sequencing and hybridization mapping of transcriptomes at molecular resolution (STARmap-ISS and STARmap-ISH) using 922,961 cells to construct a spatial single-cell atlas outlining joint epigenomic and transcriptomic regulatory dynamics. Paired analyses unraveled intricate tumor-like gene expression and transcription factor motif programs sustaining the placenta in a hostile uterine environment; further investigation of gene-linked cis-regulatory elements revealed heightened regulatory complexity governing trophoblast differentiation and placental disease risk. Complementary spatial mapping techniques decoded these programs within the placental villous core and extravillous trophoblast (EVT) cell column architecture while simultaneously revealing niche-establishing transcriptional elements and cell-cell communication. To unify our datasets, we computationally imputed 33,357-gene multiomic single-cell profiles and spatially characterized the placental chromatin accessibility landscape. This spatially resolved single-cell multiomic framework of the first trimester human placenta at molecular resolution serves as a blueprint for future studies investigating cellular and molecular programs regulating early placental development and pregnancy.</p>
Raman spectral data for mature mouse placenta scans
<p>Pre-processed and normalized Raman spectral data for three mouse placental tissue scans, and constructed image data at three different wavenumbers.</p>
Hyperspectral Placenta Dataset: Hyperspectral Image Acquisition, Annotations, and Processing of Biological Tissues in Microsurgical Training
<p>The dataset consists of 101 hyperspectral images of four fresh human placentas and six hyperspectral images of contrast dyes (i.e., indocyanine green and red and blue food colorant) that were captured in the range 515-900 nm, step = 5 nm. The hyperspectral images were manually annotated, delineating the key anatomical structures: arteries, veins, stroma, and the umbilical cord. Standard reference materials were used for flat-field correction. The dataset can be used to develop machine learning algorithms for the automated classification of biological structures, particularly the classification of superficial and deep vessels and transparent tissue layers.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.