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36 results for “Plasmodium berghei”
Experiments for detection of Plasmodium berghei infected Anopheles stephensi mosquitoes using near-infrared spectroscopy
<p> </p> <p><strong>Experiments for detection of <em>Plasmodium berghei</em> infected <em>Anopheles stephensi</em> mosquitoes using near-infrared spectroscopy</strong></p> <p>This dataset contains near-infrared spectroscopy (NIRS) measurements on <em>Plasmodium berghei</em> infected <em>Anopheles stephensi</em> mosquitoes reared in the lab together with either oocyst counts or sporozoite counts, correponding to the two experiments undertaken:</p> <ul> <li>Experiment 1 (oocysts), file "NIRSdata2017_Lab_AnSteph_PlasmBerg_oocysts.txt"</li> <li>Experiment 2 (sporozoites), file "NIRSdata2017_Lab_AnSteph_PlasmBerg_sporozoites.txt"</li> </ul> <p>For further details on the experimental setup see: P.M. Esperança, A.M. Blagborough, D.F. Da, F.E. Dowell, T.S. Churcher (2018) "Detection of <em>Plasmodium berghei</em> infected <em>Anopheles stephensi</em> using near-infrared spectroscopy". <em>Parasites and Vector</em>, <strong>11</strong>:377. <a href="https://doi.org/10.1186/s13071-018-2960-z">https://doi.org/10.1186/s13071-018-2960-z</a>.</p> <p>The structure of the data files is as follows:</p> <ul> <li>column 1 (<strong>Scan_ID</strong>): scan identifier</li> <li>column 2 (<strong>Mosquito_ID</strong>): mosquito identifier</li> <li>column 3 (<strong>Replication</strong>): replication identifier</li> <li>column 4 (<strong>Oocysts</strong> or <strong>Sporozoites</strong>): response variable <ul> <li>for the Experiment 1, the oocyst count<em> </em>on a level-scale</li> <li>for the Experiment 2, the sporozoite count on a log-scale: 0 (no sporozoites), 1 (1–10), 2 (11–100), 3 (101–1000), 4 (>1000)</li> </ul> </li> <li>columns 5 to 2155 (<strong>x350</strong> to <strong>x2500</strong>): NIRS absorbance measurements for wavelengths in the range 350 to 2500 nanometers</li> </ul> <p> </p>
A scalable CRISPR-Cas9 gene editing system facilitates CRISPR screens in the malaria parasite Plasmodium berghei - sequencing data
<p>This holds raw sequencing data, and extracted sgRNA counts </p>
Fluorescence Microscopy Images of Hela Cell infected with Plasmodium Berghei parasite expressing mCherry in cytoplasm
<p>The purpose of our experiments was to delve into the liver stage development of the P. berghei parasite and examine the host-parasite interactions using HeLa cells. This research is primarily focused on in vitro analysis and does not extend to in vivo applications. Our study investigated the integration of fluorescent microscopy with artificial intelligence to <br>track and predict the developmental milestones of Plasmodium liver stage development. </p> <p>This is the dataset used in our study.</p>
INHIBITION OF NITRIC OXIDE SYNTHESIS PROMOTES INCREASED MORTALITY DESPITE REDUCTION OF PARASITEMIA IN Plasmodium berghei-INFECTED MICE
<p><strong>Backgrounds:</strong> Nitric oxide (NO) is an important mediator molecule in inflammatory processes, but its role in the pathophysiology of malaria is still uncertain.</p> <p><strong>Methods:</strong> To investigate the NO synthesis inhibition on the oxidative changes induced by <em>Plasmodium berghei </em>infection in mice, malaria was induced in 150 animals, of which 75 animals were treated with NO inhibitor L-NAME; the remaining are sham controls. All animals underwent euthanasia after 1, 5, 10, 15 or 20 days after the infection for the collection of lungs, brain, and blood. Parasitemia was determined and the survival of the animals evaluated. Tissue samples were assayed for nitrites and nitrates (NN), thiobarbituric acid reactive substances (TBARS), and total Trolox equivalent antioxidant capacity (TEAC). A histopathological study was performed.</p> <p><strong>Results:</strong> Mortality rates in the L-NAME were always higher in relation to the controls. In brains, NN was lower in groups L-NAME. Parasitemia and its progression rate were greater in control groups. From the 5<sup>th</sup> day of infection, mice treated with L-NAME showed cerebral edema and interstitial pneumonia of greater intensity than controls.</p> <p><strong>Conclusions:</strong> Anti-inflammatory and hemodynamic effects of NO surpasses its pro-oxidant role in murine malaria.</p> <p><strong>Backgrounds:</strong> Nitric oxide (NO) is an important mediator molecule in inflammatory processes, but its role in the pathophysiology of malaria is still uncertain.</p> <p><strong>Methods:</strong> To investigate the NO synthesis inhibition on the oxidative changes induced by <em>Plasmodium berghei </em>infection in mice, malaria was induced in 150 animals, of which 75 animals were treated with NO inhibitor L-NAME; the remaining are sham controls. All animals underwent euthanasia after 1, 5, 10, 15 or 20 days after the infection for the collection of lungs, brain, and blood. Parasitemia was determined and the survival of the animals evaluated. Tissue samples were assayed for nitrites and nitrates (NN), thiobarbituric acid reactive substances (TBARS), and total Trolox equivalent antioxidant capacity (TEAC). A histopathological study was performed.</p> <p><strong>Results:</strong> Mortality rates in the L-NAME were always higher in relation to the controls. In brains, NN was lower in groups L-NAME. Parasitemia and its progression rate were greater in control groups. From the 5<sup>th</sup> day of infection, mice treated with L-NAME showed cerebral edema and interstitial pneumonia of greater intensity than controls.</p> <p><strong>Conclusions:</strong> Anti-inflammatory and hemodynamic effects of NO surpasses its pro-oxidant role in murine malaria.</p>
A G-protein-coupled receptor modulates gametogenesis via PKG-mediated signaling cascade in Plasmodium berghei
GEO Series GSE198287. Plasmodium berghei. 4 samples. Type: Expression profiling by high throughput sequencing.
Whole genome RNA micro array analysis of Plasmodium berghei sporozoites infected host cells
GEO Series GSE72049. Homo sapiens. 8 samples. Type: Expression profiling by array.
Transcriptome changes during inducible gametocytogenesis in Plasmodium berghei parasites
GEO Series GSE110201. Plasmodium berghei. 32 samples. Type: Expression profiling by high throughput sequencing.
Splenic CD4 T cells in naïve C57BL/6 mice or during Plasmodium berghei ANKA infection in C57BL/6 and B6.GzmB-/- mice.
GEO Series GSE24903. Mus musculus. 12 samples. Type: Expression profiling by array.
Transcriptome of Plasmodium berghei wildtype parasites and KIN knockout parasites [RNA-seq]
GEO Series GSE69627. Plasmodium berghei. 12 samples. Type: Expression profiling by high throughput sequencing.
The Serine/Threonine Protein Phosphatase 6 Is Required for Efficient Gametogenesis in Sexual-Stage Plasmodium berghei
GEO Series GSE271105. Plasmodium berghei ANKA. 6 samples. Type: Expression profiling by high throughput sequencing.
Pleiotropic Roles for the Plasmodium berghei RNA Binding Protein UIS12 in Anopheles Transmission and Sporogony
GEO Series GSE152686. Plasmodium berghei. 4 samples. Type: Expression profiling by array.
A divergent cyclin/cyclin-dependent kinase complex controls progression through the atypical replicative cycles during Plasmodium berghei gametogony
GEO Series GSE144743. Plasmodium berghei. 8 samples. Type: Expression profiling by high throughput sequencing.
Effects of Plasmodium berghei infection on Anopheles gambiae during oocysts development
GEO Series GSE32200. Anopheles gambiae. 8 samples. Type: Expression profiling by array.
Transcriptome changes during inducable gametocytogenesis in Plasmodium berghei parasites
GEO Series GSE168817. Plasmodium berghei. 28 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression in ap2-g and ap2-g2 mutants of Plasmodium berghei
GEO Series GSE52859. Plasmodium berghei. 8 samples. Type: Expression profiling by array.
Plasmodium berghei Gametocytogenesis
GEO Series GSE53246. Plasmodium berghei. 28 samples. Type: Expression profiling by array.
Global expression profiling reveals shared and distinct transcript signatures in arrested act2(-) and CDPK4(-) Plasmodium berghei gametocytes
GEO Series GSE65032. Plasmodium berghei. 4 samples. Type: Expression profiling by array.
A single nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity
GEO Series GSE111333. Plasmodium berghei; Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Impact of dietary restriction (DR) on the transcriptome of the rodent malaria parasite Plasmodium berghei [microarray]
GEO Series GSE69628. Plasmodium berghei. 24 samples. Type: Expression profiling by array.
Transcriptomic analysis of Plasmodium berghei apiAP2 KO mutants
GEO Series GSE80634. Plasmodium berghei. 62 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.