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17 results for “Plasmodium chabaudi”
The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi
<p>Experiments were designed to look at the relationship between infective dose and disease severity using two clones of <em>Plasmodium chabaudi</em> that differ in virulence. We asked whether there were dose–severity relationships, whether clone differences in virulence were maintained over a range of doses, and whether disease severity could be accounted for by parasite dynamics. Groups of mice were infected with parasite doses differing by an order of magnitude, ranging from 100 to 1×10<sup><sup>8</sup></sup> parasites. Infective dose affected the probability of death, but only with the more virulent clone. Dose also affected morbidity. For both clones, higher doses induced greater anaemia. Larger doses caused greater weight loss, but only for infections with the more virulent clone. Here, for a given dose, mice lost a fixed amount of weight, irrespective of their initial weight. Larger doses induced earlier mortality and morbidity than did lower dose treatments. Finally, dose affected parasite dynamics, with earlier and higher peak parasite densities in larger dose infections. All these effects were small relative to clone differences in disease severity, which were apparent across the range of doses. Dose effects were manifested through the timing and/or magnitude of peak parasite densities, broadly supporting the idea that dose affects disease severity by altering the time the host has to control parasite densities and ameliorate the effects of parasites. We discuss the possible efficacy of intervention strategies aimed at reducing human disease severity by reducing infective parasite dose.</p>
Non-targeted metabolome profiling in splenic monocyte-derived dendritic cells from Plasmodium chabaudi-infecetd mice
<p>Spleens from mice infected with Plasmodium chabaudi were processed and stained for localization of monocyte-derived dendritic cells (MODCs) by flow cytometry. The markers utilized were: Live/Dead, F4/80, CD11b, DCSign, MHCII, CD11c and CD3. After sorted out, MODCs were frozen in liquid nitrogen, followed by metabolite extraction, as recommended by The Metabolomics Facility at MD Anderson. Metabolites were extracted using ice-cold 0.1% Ammonium hydroxide in 80/20 (v/v) methanol/water. Extracts were centrifuged at 17,000 g for 5 min at 4°C, and supernatants were transferred to clean tubes, followed by evaporation to dryness under nitrogen. Dried extracts were reconstituted in deionized water, and 5 μL was injected for analysis by ion chromatography (IC)-MS. IC mobile phase A (MPA; weak) was water, and mobile phase B (MPB; strong) was water containing 100 mM KOH. A Thermo Scientific Dionex ICS-5000+ system included a Thermo IonPac AS11 column (4 µm particle size, 250 x 2 mm) with column compartment kept at 30°C. The autosampler tray was chilled to 4°C. The mobile phase flow rate was 350 µL/min and gradient from 1mM to 100mM KOH was used. The total run time was 60 min. To assist the desolvation for better sensitivity, methanol was delivered by an external pump and combined with the eluent via a low dead volume mixing tee. Data were acquired using a Thermo Orbitrap Fusion Tribrid Mass Spectrometer under ESI negative ionization mode at a resolution of 240,000.</p>
The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi
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Data from: The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi
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Whole blood transcriptome during acute phase of infecion in avirulent and virulent Plasmodium chabaudi chabaudi infection
GEO Series GSE93631. Mus musculus. 58 samples. Type: Expression profiling by array.
Whole spleen transcriptome during acute phase of infection in an avirulent Plasmodium chabaudi chabaudi AS infection.
GEO Series GSE123391. Mus musculus. 27 samples. Type: Expression profiling by array.
Daily rhythms of Plasmodium chabaudi, showing that 60% of those are intrinsic to the parasite
GEO Series GSE145855. Plasmodium chabaudi; Mus musculus. 203 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of ribo-tag pulled down Transcriptomes in renal proximal tubule epithelial cells from Plasmodium Chabaudi Chabaudi infected Egfp.l10Pepck
GEO Series GSE189579. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Whole spleen transcriptome during acute phase of infection in a virulent Plasmodium chabaudi chabaudi CB infection
GEO Series GSE145781. Mus musculus. 32 samples. Type: Expression profiling by array.
Gene expression of liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria
GEO Series GSE111110. Mus musculus. 12 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Expression data of the splenocytes from mice at 6th of Plasmodium chabaudi infection.
GEO Series GSE35083. Mus musculus. 23 samples. Type: Expression profiling by array.
Sex Differences in Response to Plasmodium chabaudi Infection: Involvement of Gonadal Steroids
GEO Series GSE4324. Mus musculus. 48 samples. Type: Expression profiling by array.
Global gene expression of the rodent malaria parasites Plasmodium yoelii, Plasmodium berghei and Plasmodium chabaudi blood-stage parasites
GEO Series GSE80015. Plasmodium yoelii; Plasmodium berghei; Plasmodium chabaudi. 36 samples. Type: Expression profiling by array.
Expression data from malaria-specific mouse CD4 T cell (PbT-II) subset after Plasmodium chabaudi infection
GEO Series GSE153600. Mus musculus. 10 samples. Type: Expression profiling by array.
Epigenetic modifications of gene promoters in the liver of Balb/c mice protected by vaccination against blood-stage malaria of Plasmodium chabaudi
GEO Series GSE87373. Mus musculus. 18 samples. Type: Methylation profiling by genome tiling array.
Transcriptomic responses in the host during mosquito-transmitted and blood passaged Plasmodium chabaudi infections.
GEO Series GSE178515. Mus musculus. 87 samples. Type: Expression profiling by high throughput sequencing.
Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)
GEO Series GSE33333. Plasmodium chabaudi chabaudi. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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