Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
112
datasets available to search
ShareScore release 0.9.0
Dataset results
112 results for “Pneumocystis”
Regional Centromere Configuration in the Fungal Pathogens of Pneumocystis Genus
<p>Supplementary material </p>
Extracellular Vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions
<p><em>Pneumocystis</em> spp. are host obligate fungal pathogens that can cause severe pneumonia in mammals and rely heavily on their host for essential nutrients. The lack of a sustainable <em>in vitro</em> culture system poses challenges in understanding their metabolism and the acquisition of essential nutrients from host lungs remains unexplored.</p> <p>Transmission electron micrographs show Extracellular Vesicles (EVs) are found near <em>Pneumocystis</em>spp. within the lung. We hypothesized that EVs transport essential nutrients to the fungi during infection. To investigate this, EVs from <em>P. carinii</em>- and <em>P. murina-</em>infected rodents were biochemically and functionally characterized. These EVs contained host proteins involved in cellular, metabolic, and immune processes as well as proteins with homologs found in other fungal EV proteomes, indicating <em>Pneumocystis</em> may release EVs. Notably, EV uptake by<em> P. carinii</em> indicated their potential involvement in nutrient acquisition and indicated a possibility for using engineered EVs for efficient therapeutic delivery. However, EVs added to <em>P. carinii</em> <em>in vitro</em>, did not show increased growth or viability, implying that additional nutrients or factors are necessary to support their metabolic requirements. Exposure of macrophages to EVs increased proinflammatory cytokine levels but did not affect macrophages' ability to kill or phagocytose <em>P. carinii</em>. These findings provide vital insights into <em>P. carinii</em> and host EV interactions, yet the mechanisms underlying <em>P. carinii</em>'s survival in the lung remain uncertain. These studies are the first to isolate, characterize, and functionally assess EVs from <em>Pneumocystis</em>-infected rodents, promising to enhance our understanding of host-pathogen dynamics and therapeutic potential.</p>
Pneumocystis spp. in pigs: a longitudinal quantitative study and co-infections assessment in Austrian farms
<p>The present upload represents the supplementary materials of the manuscript " <em>Pneumocystis</em> spp. in pigs: a longitudinal quantitative study and co-infections assessment in Austrian farms" which is under submission</p>
Fig. 1 in Pneumocystis jirovecii-from a commensal to pathogen: clinical and diagnostic review
Fig. 1 Major issues related to PcP in non-HIV patients
Extracellular Vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions
Open the record for dataset details and reuse information.
Expression Pattern of the Pneumocystis jirovecii Major Surface Glycoprotein Superfamily in Patients with Pneumonia
<p>Data set and description analyses for manuscript Schmid-Siegert et al. 2021 Journal of Infectious diseases.</p>
New Techniques for Using a Saline Wash as a Diagnostic Tool for Pneumocystis Pneumonia
ClinicalTrials.gov study NCT00342589. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients
ClinicalTrials.gov study NCT00000730. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Caspofungin for Pneumocystis Pneumonia in PLWHIV.
ClinicalTrials.gov study NCT06691321. IPD Sharing: YES. Countries: 1. Publications: 9.
Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis
ClinicalTrials.gov study NCT00000816. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Study of WR 6026 in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients
ClinicalTrials.gov study NCT00000863. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Radiomics Model for the Diagnosis of Pneumocystis Jirovecii Pneumonia in Non-HIV Patients
ClinicalTrials.gov study NCT05701631. IPD Sharing: NO. Countries: 1. Publications: 1.
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZ
ClinicalTrials.gov study NCT00000727. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pneumocystis in Pathogenesis of HIV-associated Emphysema
ClinicalTrials.gov study NCT00869544. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effect of Steroids During Pneumocystis Infection Among Non HIV Immunocompromised Patients
ClinicalTrials.gov study NCT02944045. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
ClinicalTrials.gov study NCT00001014. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
ClinicalTrials.gov study NCT00000715. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia
ClinicalTrials.gov study NCT00001003. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection
ClinicalTrials.gov study NCT00000739. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Specialized Proresolving Mediators in Pneumocystis Jirovecii Pneumonia
ClinicalTrials.gov study NCT03606252. IPD Sharing: NO. Countries: 1. Publications: 8.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.