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5,622 results for “Postoperative”
Radiographic outcomes for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Radiographic outcomes for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Clinical outcome for TheraCal LC group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for TheraCal LC group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Clinical outcome for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Radiographic outcomes for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Radiographic outcomes for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Clinical outcome for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Dataset of The Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial
<p>This the dataset related to the article entitled "he Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial".</p> <p>Purpose: Residual postoperative pain after hip arthroplasty is usually treated with oral opioids. While classic opioids are associated with respiratory depression and worsening of sleep apnea, tramadol has been reported to preserve respiratory function. However, this has not been investigated in a prospective trial using respiratory polygraphy. This randomized controlled triple-blinded trial tested the hypothesis that postoperative treatment with oral opioids such as oxycodone would increase sleep apnea severity, measured with a respiratory polygraphy, compared with oral tramadol.<br> Patients and Methods: Sixty patients undergoing hip arthroplasty under spinal anesthesia with 15 mg isobaric bupivacaine 0.5% were randomized to receive postoperative pain treatment with either oral oxycodone (controlled-release 10 mg every 12 hours and immediate-release 5 mg every 4 hours as needed) or oral tramadol (controlled-release 100 mg every 8 hours and immediate-release 50 mg every 4 hours as needed). Respiratory polygraphy was performed on the first postoperative night. The primary outcome was the apnea-hypopnea index in the supine position. Secondary outcomes included the oxygen desaturation index, postoperative pain scores and intravenous morphine consumption.<br> Results: Mean supine apnea-hypopnea index on postoperative night 1 was 11.3 events.h−1 (95% confidence interval, 4.8–17.7) in the oxycodone group and 10.7 (4.6–16.8) events.h−1 in the tramadol group (p=0.89). There were no significant differences between the oxycodone and tramadol groups with respect to any secondary sleep-related or pain-related outcomes.<br> Conclusion: Oral oxycodone did not increase sleep apnea severity measured using respiratory polygraphy compared with oral tramadol on the first postoperative night after hip arthroplasty.</p>
Dataset related to the article "Epicardial Adipose Tissue-Derived IL-1β Triggers Postoperative Atrial Fibrillation"
<p>This record contains raw data related to the article "Epicardial Adipose Tissue-Derived IL-1β Triggers Postoperative Atrial Fibrillation"</p> <p><strong>Background and aims:</strong> Post-operative atrial fibrillation (POAF), defined as new-onset AF in the immediate period after surgery, is associated with poor adverse cardiovascular events and a higher risk of permanent AF. Mechanisms leading to POAF are not completely understood and epicardial adipose tissue (EAT) inflammation could be a potent trigger. Here, we aim at exploring the link between EAT-secreted interleukin (IL)-1β, atrial remodeling, and POAF in a population of coronary artery disease (CAD) patients. <strong>Methods:</strong> We collected EAT and atrial biopsies from 40 CAD patients undergoing cardiac surgery. Serum samples and EAT-conditioned media were screened for IL-1β and IL-1ra. Atrial fibrosis was evaluated at histology. The potential role of NLRP3 inflammasome activation in promoting fibrosis was explored <em>in vitro</em> by exposing human atrial fibroblasts to IL-1β and IL-18. <strong>Results:</strong> 40% of patients developed POAF. Patients with and without POAF were homogeneous for clinical and echocardiographic parameters, including left atrial volume and EAT thickness. POAF was not associated with atrial fibrosis at histology. No significant difference was observed in serum IL-1β and IL-1ra levels between POAF and no-POAF patients. EAT-mediated IL-1β secretion and expression were significantly higher in the POAF group compared to the no-POAF group. The <em>in vitro</em> study showed that both IL-1β and IL-18 increase fibroblasts' proliferation and collagen production. Moreover, the stimulated cells perpetuated inflammation and fibrosis by producing IL-1β and transforming growth factor (TGF)-β. <strong>Conclusion:</strong> EAT could exert a relevant role both in POAF occurrence and in atrial fibrotic remodeling.</p>
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
ClinicalTrials.gov study NCT04108130. IPD Sharing: YES. Countries: 1. Publications: 11.
Deferoxamine Regulates Neuroinflammation and Iron Homeostasis in a Mouse Model of Postoperative Cognitive Dysfunction
<p>The raw data of the manuscript” Deferoxamine Regulates Neuroinflammation and Iron Homeostasis in a Mouse Model of Postoperative Cognitive Dysfunction”</p>
HypnoChild: A prospective randomized trial to reduce perioperative anxiety and postoperative discomfort in children using a hypnosis intervention before tonsillotomy and adenoidectomy
<p><strong>Introduction</strong>: Children undergoing tonsillotomy (TT) or adenoidectomy (AT) often suffer from anxiety before and pain or nausea after the procedure. Greater preoperative anxiety in children and their parents is associated with increased postoperative discomfort. The aim of the HypnoChild study is to reduce perioperative anxiety with a preoperative hypnosis intervention and thereby alleviate postoperative discomfort.</p><p><strong>Material/Methods</strong>: In a previous pilot study, we developed a narcosis comic with a little monkey as the protagonist to reduce children's preoperative anxiety. In HypnoChild, we investigated whether a hypnosis audio intervention further reduces children's perioperative anxiety. Here, the little monkey describes the surgery as an adventurous space journey. We included children 3-6 years old receiving TT or AT. 34 children prepared for surgery with the hypnosis audio intervention in addition to the comic (comic+hypnosis group), while 30 children received the comic only (comic group). All children received premedication by midazolam. We measured children's subjective well-being before and after surgery, parents' anxiety before surgery, children's anxiety during surgery, and children's postoperative pain and nausea.</p><p><strong>Results</strong>: Children showed high well-being before and after surgery in both groups. Parents' anxiety was on a moderate level in both groups. Children's anxiety was low to moderate in both groups during surgery. In the postoperative telephone interviews, children reported medium pain ratings in both groups with no significant differences in any postoperative outcome between groups.</p><p><strong>Conclusion</strong>: Our study shows that all children participating in our study reported high well-being and low anxiety undergoing TT or AT. We conclude that apparently children already received adequate preoperative treatment by routine care. In future studies, it should be assessed if the combination of non-medical interventions like comic and hypnosis shows an additive effect in non-medicated children.</p><p>This research was funded by a DFG grant to Dr. Barbara Schmidt, SCHM 3129/5-1</p>
DATASET RELATED TO ARTICLE "Brain Tumor Resection in Elderly Patients Potential Factors of Postoperative Worsening in a Predictive Outcome Model"
<p><span>clinical database including information on patients included in the study at title</span></p>
Association between preoperative medication lists and postoperative hospital length of stay after endoscopic transsphenoidal pituitary surgery
<p><strong><span>Background</span></strong><span>:</span> <span>Endoscopic transsphenoidal surgery is the most common technique for resection of pituitary adenoma. Data on factors associated with extended hospital stay after this surgery are limited. We aimed to characterize the relationship between preoperative medications and the risk of prolonged postoperative length of stay after this procedure.</span></p> <p><strong><span>Methods</span></strong><span>:</span> <span>This single-center, retrospective cohort study included all adult patients scheduled for transsphenoidal pituitary surgery from July 1</span><span>st,</span><span> 2016 to December 31</span><span>st</span><span>, 2019.</span> <span>Anatomical Therapeutic Chemical</span><span> codes were used to identify patients' preoperative medications. The primary outcome was prolonged postoperative hospital length of stay. Secondary outcomes included unplanned admission to the Intensive Care Unit, in-hospital and one-year mortality. We developed a descriptive logistic model that included preoperative medications, obesity, and age.</span></p> <p><strong><span>Results</span></strong><span>:</span> <span>Median postoperative length of stay was 3 days for the 7</span><span>04 </span><span>analyzed patients. A prolonged length of stay was</span> <span>defined as > 4 days. Patients taking ATC-H drugs were at increased risk of prolonged length of stay (OR 1.56, 95% CI 1.26-1.95, p<0.001). No association was found between preoperative ATC-H medication and unplanned ICU admission or in-hospital mortality. Patients with multiple preoperative ATC-H medications had significantly higher mean LOS (5.4 ± 7.6 days) and one-year mortality (p<0.02).</span></p> <p><strong><span>Conclusions</span></strong><span>: Clinicians should be aware of the possible vulnerability of patients taking systemic hormones preoperatively. Future studies should test this medication-based approach on endoscopic transsphenoidal pituitary surgery populations from different hospitals and countries.</span></p>
Metabolic syndrome for the prognosis of postoperative complications after open pancreatic surgery in Chinese adult: a propensity score matching study
<p><strong>Background: </strong>To investigate the relationship between metabolic syndrome (MS) and postoperative complications in Chinese adults after open pancreatic surgery.</p> <p><strong>Methods: </strong>Relevant data were retrieved from the Medicalsystem® database of Changhai hospital (MDCH). All patients who underwent pancreatectomy from January 2017 to May 2019 were included, and relevant data were collected and analyzed. A propensity score matching (PSM) and a multivariate generalized estimating equation were used to investigate the association between MS and composite compositions during hospitalization. Cox regression model was employed for survival analysis.</p> <p><strong>Results: </strong>1481 patients were finally eligible for this analysis. According to diagnostic criteria of Chinese MS, 235 patients were defined as MS, and the other 1246 patients were controls. After PSM, no association was found between MS and postoperative composite complications (OR: 0.958, 95%CI: 0.715-1.282, P=0.958). But MS was associated with postoperative acute kidney injury (OR: 1.730, 95%CI: 1.050-2.849, P=0.031). Postoperative AKI was associated with mortality in 30 days and 90 days after surgery (P<0.001).</p> <p><strong>Conclusions: </strong>MS is not an independent risk factor correlated with postoperative composite complications after open pancreatic surgery. But MS is an independent risk factor for postoperative AKI of pancreatic surgery in Chinese population, and AKI is associated with survival after surgery.</p>
Comprehensive assessment of postoperative mobility during the first days after mini-invasive lung surgery: A prospective observational study
<p><span>Study Objective</span><span>: </span><span>Postoperative physical therapy and early mobilization are major elements of </span><span>enhanced recovery after surgery. In contrast with supervised physical therapy sessions that can be monitored, self-mobilization is not easily quantifiable and has so far been estimated mainly through patient auto-reports. This study aimed to perform a comprehensive and objective evaluation of postoperative mobility.</span></p> <p><span>Design</span><span>: </span><span>Prospective observational study.</span></p> <p><span>Setting</span><span>: </span><span>Postoperative setting.</span></p> <p><span>Patients</span><span>: </span><span>Patients undergoing mini-invasive lung surgery.</span></p> <p><span>Interventions</span><span>: </span><span>Measurement of postoperative mobility during the five first postoperative days using an accelerometer (ActiGraph GT3X).</span></p> <p><span>Measurements</span><span>: </span><span>The primary outcome was the number of daily steps. Secondary outcomes included physical activity duration and intensity, sedentary time, number of breaks in sedentary time, sedentary patterns, daily evaluation by physiotherapists, postoperative complications, and acceptability of wearing the accelerometer. </span></p> <p><span>Main Results: </span><span>Sixty patients were included in the study, of whom 56 provided at least one day of valid accelerometry data. There was no significant change during the first four PODs concerning the number of daily steps nor the mean cadence. One-minute cadence peak, total activity counts, and duration of light-intensity physical activity increased over time (P = 0.032, P = 0.001 and P = 0.001, respectively). </span><span>Sedentary patterns changed favorably over time, with a decrease in prolonged sedentary bouts (≥ 60 consecutive min), and an increase in shorter bouts (< 10 min) (</span><span>P </span><span>< 0.001). Similar results were observed when analysis was adjusted for the day of the week when the surgery took place except for daily sedentary time (P = 0.055). The median acceptability of wearing the accelerometer was excellent (median 10 [9-10] on a 10-point Likert scale). Three patients had major complications. </span></p> <p><span>Conclusions: </span><span>Our findings suggest that daily steps may not be the most relevant indicator of early mobility following thoracic surgery and that accelerometry is suitable to follow patient's early postoperative activity.</span></p>
Dataset: Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia
<p>This dataset contains arm-level data for the outcome length of stay in hospital (days) from the paper https://doi.org/10.1016/j.jclinepi.2018.02.012 which was initially presented in the paper https://doi.org/10.1002/14651858.CD008646.pub2. </p>
Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)
ClinicalTrials.gov study NCT03237481. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer
ClinicalTrials.gov study NCT00798655. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
ClinicalTrials.gov study NCT05618912. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of Tizanidine on Postoperative Urinary Retention After Sacrospinous Suspension
ClinicalTrials.gov study NCT06258785. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Randomized, Double-Blind, Single-Dose, Efficacy and Safety Study of Test Acetaminophen Tablet in Postoperative Dental Pain
ClinicalTrials.gov study NCT03224403. IPD Sharing: YES. Countries: 1. Publications: 2.
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