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15
datasets available to search
ShareScore release 0.9.0
Dataset results
15 results for “Prevotella”
Hadza Prevotella Require Diet-derived Microbiota Accessible Carbohydrates to Persist in mice.
<p>Raw reads for whole genome sequencing and RNAseq for Gellman et al., 2023.</p>
Data from: Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production
<p><strong>Objective </strong>Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the effects of PU and its mechanisms in mitigating AS in both mice and humans.</p> <p><strong>Design </strong>The impact of PU on AS was examined in <em>ApoE</em><sup>-/-</sup> mice fed a high-fat diet (HFD) and in human patients with carotid artery plaque. To explore the causal link between PU-associated gut microbiota and AS, faecal microbiota transplantation (FMT) and mono-colonization of mice with <em>Prevotella copri</em> (<em>P. copri</em>) were employed.</p> <p><strong>Results </strong>PU alleviated AS by modulating the gut microbiota, as evidenced by alterations in gut microbiota composition and the amelioration of AS following FMT from PU-treated mice into <em>ApoE</em><sup>-/-</sup> mice fed HFD. Specifically, PU reduced the abundance of <em>P. copri</em>, which exacerbated AS by producing trimethylamine (TMA). Prolonged mono-colonization of <em>P. copri</em> undermines the beneficial effects of PU on AS. In clinical, the plaque scores of AS patients were positively correlated with the abundance of <em>P. copri</em> and plasma trimethylamine-N-oxide (TMAO) levels. A 1-week oral intervention with PU effectively decreased <em>P. copri</em> levels and reduced TMAO concentrations in patients with carotid artery plaque.</p> <p><strong>Conclusion </strong>PU may provide therapeutic benefits in combating AS by targeting <em>P. copri</em> and its production of TMA.</p>
Genome assemblies for Hadza Prevotella Require Diet-derived Microbiota Accessible Carbohydrates to Persist in mice.
<p>Genome scaffolds, annotations, and CAZy prediction for Gellman et al., 2023.</p>
Data from: Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production
Open the record for dataset details and reuse information.
CFTR mutation abrogates Prevotella regulation of epithelial cell defense against Staphylococcus aureus
GEO Series GSE305398. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Synergistic Exacerbation of Oral Streptococci-induced pneumonia due to Prevotella intermedia
GEO Series GSE278151. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Study on the Mechanism of Prevotella Copri Promoting the Occurrence and Development of Atherosclerosis
ClinicalTrials.gov study NCT06047249. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevotella copri facilitates wound healing in mice through the sphingosine-CerS1-ceramide metabolic pathway
GEO Series GSE296532. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Prevotella ruminicola 23: Growth on different carbohydrate sources
GEO Series GSE19088. Xylanibacter ruminicola 23; Xylanibacter ruminicola. 34 samples. Type: Expression profiling by array.
Role of OxyR in Prevotella intermedia
GEO Series GSE168003. Prevotella intermedia. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome sequencing of primary human oral keratinocytes co-cultured with Prevotella melaninogenica
GEO Series GSE220609. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Solithromycin mitigates Prevotella intermedia–induced exacerbation of MRSA ventilator-associated pneumonia by modulating hyperinflammatory responses and enhancing alveolar macrophage function
GEO Series GSE307943. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Role of iron in gene regulation in Prevotella intermedia
GEO Series GSE168982. Prevotella intermedia. 8 samples. Type: Expression profiling by high throughput sequencing.
Correlation of Prevotella abundancy with a particular carbohydrate-active CAZy enzyme profile in healthy gut microbiota
<p>Data_microbiota</p>
Correlation of Prevotella abundancy with a particular carbohydrate-active CAZy enzyme profile in healthy gut microbiota
<p>Microbiota data</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.