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167 results for “Primary Open Angle Glaucoma”
miRNAs in primary open-angle glaucoma and ocular hypertension
<p>Glaucoma is a chronic neurodegenerative disease, which is the leading cause of irreversible blindness worldwide. As a response to high intraocular pressure, the clinical and molecular glaucoma biomarkers indicate the biological state of the visual system. Classical and uncovering novel biomarkers of glaucoma development and progression, follow-up, and monitoring the response to treatment are key objectives to improve vision outcomes. While the glaucoma imaging field has successfully validated biomarkers of disease progression, there is still a considerable need for developing new biomarkers of early glaucoma, that is, at the preclinical and initial glaucoma stages. Outstanding clinical trials and animal-model study designs, innovative technology, and analytical approaches in bioinformatics are essential tools to successfully uncover novel glaucoma biomarkers with a high potential for translation into clinical practice. To better understand the clinical and biochemical–molecular–genetic glaucoma pathogenesis, we conducted an analytical, observational, and case-comparative/control study in 358 primary open-angle glaucoma (POAG) patients and 226 comparative-control individuals to collect tears, aqueous humor, and blood to process for identifying POAG biomarkers by exploring several biological pathways, such as inflammation, neurotransmitter/neurotrophin alteration, oxidative stress, gene expression, miRNAs fingerprint and its biological targets, and vascular endothelial dysfunction. We are incredibly enthusiastic about gathering as much information as possible on POAG biomarkers to learn how this information can be used to better steer the diagnosis and therapy of glaucoma to prevent blindness in the predictable future.</p>
Efficacy and Safety Study of Netarsudil 0.02% Ophthalmic Solution Compared to Ripasudil Hydrochloride Hydrate 0.4% Ophthalmic Solution in Japanese Subjects With Primary Open Angle Glaucoma or Ocular H
ClinicalTrials.gov study NCT04620135. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT01241240. IPD Sharing: Not stated. Countries: 2. Publications: 1.
An Observational Study of Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Who Switched IOP-lowering Treatments
ClinicalTrials.gov study NCT01735214. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT01217606. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
ClinicalTrials.gov study NCT00824824. IPD Sharing: NO. Countries: 1. Publications: 1.
Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular H
ClinicalTrials.gov study NCT04742283. IPD Sharing: NO. Countries: 1. Publications: 0.
A Safety and Efficacy Study of Bimatoprost 0.01% in Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OH)
ClinicalTrials.gov study NCT01594970. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan® UD Monotherapy for Medical Reasons
ClinicalTrials.gov study NCT01853085. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study
ClinicalTrials.gov study NCT03216902. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Safety and Performance Study of the ARGOS-IO (Intraocular) System in Patients With Primary Open Angle Glaucoma (POAG)
ClinicalTrials.gov study NCT02434692. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants
ClinicalTrials.gov study NCT02006693. IPD Sharing: Not stated. Countries: 9. Publications: 2.
Long-term Safety and Performance of the ARGOS-IO Intraocular Pressure Sensor System in Subjects With Primary Open Angle Glaucoma (POAG)
ClinicalTrials.gov study NCT03651336. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension
ClinicalTrials.gov study NCT02061683. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of GANFORT® UD in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) in a Medical Setting
ClinicalTrials.gov study NCT01999348. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Effectiveness of the Sight Sciences VISCO™360 Versus SLT in Primary Open Angle Glaucoma
ClinicalTrials.gov study NCT02928289. IPD Sharing: Not stated. Countries: 1. Publications: 1.
miRNAs in primary open-angle glaucoma and ocular hypertension
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Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients
<p><strong>Background: </strong>Primary open-angle glaucoma (POAG) is a multifactorial disease that affects 65.5 million people worldwide. In addition to the genetic variants already established as indicators of greater risk for POAG, the apolipoprotein (<i>APOE</i>) gene has been studied in some populations, with controversial results. The aim of this study is to investigate the frequency of the genetic variants of <i>APOE</i> in the Brazilian population, and to evaluate the association between these polymorphisms and the risk of POAG.</p> <p><strong>Methods:</strong> <em>APOE</em> variants (rs429358; rs7412) were genotyped in 402 POAG patients and 401 controls. We evaluated the association between <em>APOE</em> genetic variants and the risk for POAG, as well as the correlation between the requirement of glaucoma surgery and the APOE polymorphisms. </p> <p><strong>Results: </strong>Among the three APOE gene isoforms, we found a low frequency of APOE alleles ε2 (7.34%) and ε4 (11.76%), but a high frequency of ε3 (80.88%) in our population. When compared to ε3ε3 reference genotype, ε2 allele-carriers (OR=1.516; p-value=0.04) and ε2ε3 genotype (OR=1.655; p-value=0.02) were associated with a greater risk for POAG. An additive genetic model confirmed the influence of the ε2 allele in the risk of POAG in this sample of the Brazilian population (OR=1.502; p-value=0.04). There was no significant association between the analyzed genotypes and the requirement or number of glaucoma surgeries (p>0.05). </p> <p><strong>Conclusion: </strong>Brazilian individuals carrying the APOEε2 allele may be at an increased risk for the development of POAG.</p>
The Effect of Dronabinol on Ocular Hemodynamics in Patients With Primary Open Angle Glaucoma
ClinicalTrials.gov study NCT04596826. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT06177678. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
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