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68 results for “Pro-inflammatory cytokines”
Data from: Behavioural infection tolerance of malaria is negatively correlated with pro-inflammatory cytokine expression in the brain of an invasive songbird
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Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19
ClinicalTrials.gov study NCT06676709. IPD Sharing: YES. Countries: 1. Publications: 26.
CCL20 expression in human keratinocytes upon cytokine, pro-inflammatory, and UV stimuli.
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Fig. 8. Ochrathinols A in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 8. Ochrathinols A (±)-1 compensated the NAD+/NADH ratio induced by LPS. Cells were exposed to 0.1 μg/mL LPS and co-treated with compounds of (±)-1 (10 μM) for 24 h. Intracellular NAD+/NADH ratios were determined by NAD+/NADH assay kit. Data are shown as mean ± SD (n = 3). *P <0.05, ****P <0.001 vs. LPS group, n = 3. P value was assessed by two-tailed Student's t-test.
Fig. 7 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 7. Anti-inflammation activity of ochrathinols A and B ((±)-1, (±)-2). Cells were exposed to 0.1 μg/mL LPS and co-treated with compounds of (+)-1, ()-1, (±)-1, (+)-2, ()-2, (±)-2 (10 μM) for 24 h, respectively. (A) (±)-1 reduced the release of LPS-induced IL-6, TNF-α, and MCP-1 in culture medium, n = 3. (B) qPCR analysis of pro-inflammatory cytokines genes (IL-1β, IL-6, TNF-α, and MCP-1) normalized by β-actin, n = 3. All data are presented as the mean ± SD of three independent experiments. ns, P> 0.05, *P <0.05, **P <0.01, ***P <0.005, ****P <0.001 vs. LPS group; #P <0.05, ##P <0.01, ###P <0.005, ####P <0.001 vs. control group, n = 3. P value was assessed by two-tailed Student's t-test.
Comparing Pro-Inflammatory Cytokines and Bone Metabolism Mediators Around Laser-Lok and Machined Transmucosal Abutments
ClinicalTrials.gov study NCT03572244. IPD Sharing: NO. Countries: 0. Publications: 26.
Effects of Auricular Vagus Nerve Stimulation on the Pro-inflammatory Cytokine Response in Healthy Adults
ClinicalTrials.gov study NCT01569789. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pro-inflammatory Cytokines in Facioscapulohumeral Muscular Dystrophy (CYTOKINE-FSH)
ClinicalTrials.gov study NCT04694456. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10)
Microglia respond to CNS injuries and diseases with complex reactions, often called "activation." A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations for this study. First, bacterial endotoxin (lipopolysaccharide, LPS) is the most commonly used pro-inflammatory stimulus for microglia, both in vitro and in vivo; however, pro-inflammatory cytokines (e.g., IFNγ, TNFα) rather than LPS will be encountered with sterile CNS damage and disease. We lack direct comparisons of responses between LPS and such cytokines. Second, while transcriptional profiling is providing substantial data on microglial responses to LPS, these studies mainly use mouse cells and models, and there is increasing evidence that responses of rat microglia can differ. Third, the cytokine milieu is dynamic after acute CNS damage, and an important question in microglial biology is: How malleable are their responses? There are very few studies of effects of resolving cytokines, particularly for rat microglia, and much of the work has focused on pro-inflammatory outcomes. Here, we first exposed primary rat microglia to LPS or to IFNγ+TNFα (I+T) and compared hallmark functional (nitric oxide production, migration) and molecular responses (almost 100 genes), including surface receptors that can be considered part of the sensome. Protein changes for exemplary molecules were also quantified: ARG1, CD206/MRC1, COX-2, iNOS, and PYK2. Despite some similarities, there were notable differences in responses to LPS and I+T. For instance, LPS often evoked higher pro-inflammatory gene expression and also increased several anti-inflammatory genes. Second, we compared the ability of two anti-inflammatory, resolving cytokines (IL-4, IL-10), to counteract responses to LPS and I+T. IL-4 was more effective after I+T than after LPS, and IL-10 was surprisingly ineffective after either stimulus. These results should prove useful in modeling microglial reactivity in vitro; and comparing transcriptional responses to sterile CNS inflammation in vivo.
Fig. 6 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 6. Chiral HPLC analyses of ochrathinol B (±)-2.
Fig. 4 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 4. Experimental and calculated ECD spectra of (±)-1, (±)-2, and 4.
Fig. 3. X in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 3. X-ray crystallographic structures of compounds 1–3.
Fig. 2 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 2. Key COSY (bold) and HMBC (arrows) correlations of 1 4.
Fig. 5 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 5. Chiral HPLC analyses of ochrathinol A (±)-1.
Fig. 1 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
Fig. 1. Structures of compounds 1–4.
Data from: Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10)
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Pro-inflammatory cytokines promote selective transcription of circular RNAs in human pancreatic β cells
GEO Series GSE209612. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes [RNA-seq]
GEO Series GSE110386. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
GEO Series GSE253299. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Treatment of granuloma annulare and suppression of pro-inflammatory cytokine activity with tofacitinib [RNA-Seq]
GEO Series GSE158923. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.