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8 results for “Protocell”
Microscopy and biophysical data for: Synthetic control of actin polymerization and symmetry breaking in active protocells
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Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world
<p>The encapsulation of genetic material inside compartments together with the creation and sustenance of functionally diverse internal components are likely to have been key steps in the formation of 'live', replicating protocells in an RNA world. Several experiments have shown that RNA encapsulated inside lipid vesicles can lead to vesicular growth and division through physical processes alone. Replication of RNA inside such vesicles can produce a large number of RNA strands. Yet, the impact of such replication processes on the emergence of the first ribozymes inside such protocells and on the subsequent evolution of the protocell population remains an open question. In this paper, we present a model for the evolution of protocells with functionally diverse ribozymes. Distinct ribozymes can be created with small probabilities during the error-prone RNA replication process via the rolling circle mechanism. We identify the conditions that can synergistically enhance the number of different ribozymes inside a protocell and allow functionally diverse protocells containing multiple ribozymes to dominate the population. Our work demonstrates the existence of an effective pathway towards increasing complexity of protocells that might have eventually led to the origin of life in an RNA world.</p>
DNA sequences for: Synthetic control of actin polymerization and symmetry breaking in active protocells
<p>Non-linear biomolecular interactions on membranes drive membrane remodeling crucial for biological processes including chemotaxis, cytokinesis, and endocytosis. The complexity of biomolecular interactions, their redundancy, and the importance of spatiotemporal context in membrane organization impede understanding of the physical principles governing membrane mechanics. Developing a minimal in vitro system that mimics molecular signaling and mem- brane remodeling while maintaining physiological fidelity poses a significant challenge. Inspired by chemotaxis, we reconstructed chemically regulated actin polymerization inside vesicles, guiding membrane self-organization. An external, undirected chemical input induced directed actin polymerization and membrane deformation uncorrelated with upstream biochemical cues, suggesting symmetry breaking. A biophysical model incorporating actin dynamics and membrane mechanics proposes that uneven actin distributions cause non-linear membrane deformations, consistent with experimental findings. This protocellular system illuminates the interplay between actin dynamics and membrane shape during symmetry breaking, offering insights into chemotaxis and other cell biological processes.</p>
Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world
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DNA sequences for: Synthetic control of actin polymerization and symmetry breaking in active protocells
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Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation
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Functional and morphological adaptation in DNA protocells via signal processing prompted by artificial metalloenzymes
<p>Data underlying the figures in the publication “Functional and morphological adaptation in DNA protocells via signal processing prompted by artificial metalloenzymes”, published in<em> Nat. Nanotechnol., </em><strong>2020</strong>, 15, 914–921. <a href="https://doi.org/10.1038/s41565-020-0761-y">https://doi.org/10.1038/s41565-020-0761-y</a></p> <p>Table of contents:</p> <p><strong>1. Dataset</strong>; Excel file containing the numerical data for <em>Figure 3</em>: Metathesis kinetics, mutant screenings and crowding.</p> <p><strong>2. Experimental Information</strong>; Word file containing the experimental protocols for synthesis and analysis.</p> <p> </p> <p> </p>
Dataset for "Reprogramming macrophages with R848-loaded artificial protocells to modulate skin and skeletal wound healing"
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.