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72 results for “Pyrrole”
Cobalt-Mediated Photochemical C−H Arylation of Pyrroles
<p>Optimized geometries in xyz-format, supplement to the journal article published in <em>Angew. Chem. Int. Ed. </em><strong>2024</strong>, e202405780 (<a href="https://doi.org/10.1002/anie.202405780">https://doi.org/10.1002/anie.202405780</a>).</p>
Water is a radiation protection agent for ionised pyrrole
<p>Data and scripts for the manuscript with the title: Water is a radiation protection agent for ionised pyrrole</p>
Optical and NMR spectra along with atomic coordinates of the title compounds for: Deciphering the Enigma of Unusual Fluorescence in Weakly Coupled Bis-nitro-pyrrolo[3,2-b]pyrroles
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Figure 5 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Figure 5 Major intermolecular interactions between 12d and the active site of AChE (PDB: 1Q84). The interactions are provided in 2D (A) and 3D (B) forms. The AChE enzyme is depicted in grey while the active inhibitor – 12d, is presented as green sticks with its electrostatic potential.
Figure 4 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Figure 4 Inhibitory activity of the top ranked ligands against AChE (10 μM concentrations). * P < 0.1; *** P < 0.001 vs control (pure eeAChE). Data are presented as means from three independent experiments ± SD.
Supplementary material 1 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Docking scores and MM/GBSA recalculation of the applied dataset
Figure 3 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Figure 3 Superimposed native conformation of TZ4 and the re-docking conformations acquired with Glide (A) and GOLD 5.3 (B).
Scheme 5 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 5 Synthesis of substituted pyrroles from 1,4-diaryl-2-butene-1,4-diones and ammonium formate.
Scheme 2 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 2 Pathways for the Paal-Knorr synthesis of pyrroles: A. the enamine pathway and B. the hemiaminal pathway.
Scheme 3 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 3 Formation of N-unsubstituted pyrrole by the reaction of urea and acetonylacetone absorbed over K10 in a microwave oven.
Scheme 15 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 15 A plausible mechanism of calcium(II) chloride catalyzed Paal-Knorr condensation under MW irradiation.
Scheme 23 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 23 Synthesis of new pyrrole-based compound by reaction of 3-nitro-2H-chromenes with an ethyl isocyanoacetate.
Scheme 8 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 8 MW assisted Paal-Knorr condensation of cyclopentenone to a set of tricyclic pyrrole- 2-carboxamides.
Figure 3 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Figure 3 Number of published articles containing "microwave synthesis" indexed in Scopus (accessed 09.2023).
Scheme 9 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 9 Microwave induced uncatalyzed reaction of 2,5-dimethoxytetrahydrofuran with aryl sulfonamides and anilines in water.
Scheme 20 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 20 MW synthesis of pyrrole starting from 2,5-dimethoxytetrahydrofuran in the presence of an Mn-based catalyst.
Scheme 6 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 6 Cyclization of diketons with amines under microwave irradiation. Conditions: (a) NaOH, EtOH/H2O, reflux, 10 min. (b) Toluene, reflux, 12 h.
Scheme 12 from: Mateev E, Irfan A, Mateeva A, Georgieva M, Zlatkov A (2024) Microwave-assisted organic synthesis of pyrroles (Review). Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119866
Scheme 12 Synthesis of N-substituted pyrroles starting from 2,5-hexanedione and amine using N-bromosuccinimide as catalyst and microwave oven.
Figure 5 from: Tzankova D, Peikova L, Vladimirova S, Georgieva M (2019) Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring. Pharmacia 66(3): 127-134. https://doi.org/10.3897/pharmacia.66.e47035
Figure 5 Chromatogram of the separated mixture of the analyzed hydrazone D-5d (tR = 6.800) and its possible degradation products – the hydrazide D-5 (tR = 4.387) and the corresponding aldehyde d (tR = 1.387).
Figure 7 from: Tzankova D, Peikova L, Vladimirova S, Georgieva M (2019) Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring. Pharmacia 66(3): 127-134. https://doi.org/10.3897/pharmacia.66.e47035
Figure 7 Chromatograms indicating the behavior of D_5d in the presence of buffer with pH 2.0 and at 37°C at 0th min (A) and at 30th min (B).
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