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ShareScore release 0.9.0
Dataset results
156 results for “RNA polymerase pausing”
Data from: A global change in RNA polymerase II pausing during the Drosophila midblastula transition
Massive zygotic transcription begins in many organisms during the midblastula transition when the cell cycle of the dividing egg slows down. A few genes are transcribed before this stage but how this differential activation is accomplished is still an open question. We have performed ChIP-seq experiments on tightly staged Drosophila embryos and show that massive recruitment of RNA polymerase II (Pol II) with widespread pausing occurs de novo during the midblastula transition. However, ∼100 genes are strongly occupied by Pol II before this timepoint and most of them do not show Pol II pausing, consistent with a requirement for rapid transcription during the fast nuclear cycles. This global change in Pol II pausing correlates with distinct core promoter elements and associates a TATA-enriched promoter with the rapid early transcription. This suggests that promoters are differentially used during the zygotic genome activation, presumably because they have distinct dynamic properties.
Data from: A global change in RNA polymerase II pausing during the Drosophila midblastula transition
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Regulation of Mammalian Cell Growth and Survival By an RNA Polymerase II-Pausing Factor (Gene expression)
GEO Series GSE24114. Mus musculus. 4 samples. Type: Expression profiling by array.
PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and controls RNA polymerase pause release at select gene targets [RNA-Seq]
GEO Series GSE183297. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Mutant FOXO1 Controls an Oncogenic Network via Enhancer Accessibility and RNA Polymerase Pause Release [ChIP-seq/CUT&RUN]
GEO Series GSE254405. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and controls RNA polymerase pause release at select gene targets [ATAC-Seq II]
GEO Series GSE188668. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis
GEO Series GSE228454. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing; Other.
PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and controls RNA polymerase pause release at select gene targets
GEO Series GSE183281. Homo sapiens. 209 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Essential Signaling Function of Cytoplasmic NELFB Independent of RNA Polymerase II Pausing
GEO Series GSE205388. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing.
Release of paused RNA-Polymerase II at specific introns and chromatin domains favors spontaneous DNA double strand break formation and predicts cancer translocations [RNA-seq]
GEO Series GSE93039. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer
GEO Series GSE271735. Homo sapiens. 18 samples. Type: Other.
Dynamics of RNA polymerase II pausing and bivalent histone H3 methylation during neuronal differentiation in brain development
GEO Series GSE93011. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
RNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II
GEO Series GSE62171. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [RNA-seq]
GEO Series GSE280102. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Mutant FOXO1 Controls an Oncogenic Network via Enhancer Accessibility and RNA Polymerase Pause Release [ATAC-Seq]
GEO Series GSE243496. Homo sapiens. 29 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer
GEO Series GSE271731. Homo sapiens. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Release of paused RNA-Polymerase II at specific introns and chromatin domains favors spontaneous DNA double strand break formation and predicts cancer translocations [ChIP-seq & BLISS]
GEO Series GSE93038. Homo sapiens. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Signaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: Estrogen dependent signaling in MCF-7 cells
GEO Series GSE41324. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
GEO Series GSE96672. Homo sapiens. 36 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (RNA-Seq)
GEO Series GSE265884. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.