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3,361 results for “Randomized controlled trials”
Inter-Chemical Correlation results for the study: HHEARx2017-1967 (Perfluoroalkyl and Polyfluroalkyl Substances (PFAS), Protein Biomarkers, Adiposity and Cardiometabolic Risk Factors in a 3-year Cohort of Low-Income Latino Children with Overweight and Obesity from the Stanford GOALS Randomized Controlled Trial)
Title: Perfluoroalkyl and Polyfluroalkyl Substances (PFAS), Protein Biomarkers, Adiposity and Cardiometabolic Risk Factors in a 3-year Cohort of Low-Income Latino Children with Overweight and Obesity from the Stanford GOALS Randomized Controlled Trial <br>Species: Homo sapiens <br>Number of samples: 1085 <br>Number of named analytes: 8 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=36 <br>
First Steps towards a Risk of Bias Corpus of Randomized Controlled Trials
<p><strong>Abstract</strong></p> <p>Risk of bias (RoB) assessment of randomized clinical trials (RCTs) is vital to conducting systematic reviews. Manual RoB assessment for hundreds of RCTs is a cognitively demanding, lengthy process and is prone to subjective judgment. Supervised machine learning (ML) can help to accelerate this process but requires a hand-labelled corpus. There are currently no RoB annotation guidelines for randomized clinical trials or annotated corpora. In this pilot project, we test the practicality of directly using the revised Cochrane RoB 2.0 guidelines for developing an RoB annotated corpus using a novel multi-level annotation scheme. We report inter-annotator agreement among four annotators who used Cochrane RoB 2.0 guidelines. The agreement ranges between 0% for some bias classes and 76% for others. Finally, we discuss the shortcomings of this direct translation of annotation guidelines and scheme and suggest approaches to improve them to obtain an RoB annotated corpus suitable for ML.</p> <p> </p> <p><strong>Methods</strong></p> <p>The upload contains two zip files and a .json file.</p> <ul> <li>plain.html.zip</li> </ul> <p>Original corpus (n = 10) in .html format. The corpus was generated using the methodology described in the paper. Each .html file could be opened in any default text editor in any operating system or browser. A .html contains full text divided into several annotatable text parts. </p> <p> </p> <ul> <li>ann.json.zip</li> </ul> <p>The .zip contains RoB annotations conducted by the authors (R.H., M.S., K.G., R.C.). The annotation files are in .json format. Each .json is divided into two JSON objects and three JSON arrays. </p> <ol> <li>annotatable (object): Parts from the full-text document corresponding to the text parts from the plain .html files. </li> <li>metas (object): full-text document label</li> <li>entities (array): contains labelled entities. Each entity is linked to which part of the full-text it is linked to.</li> <li>relations (array)</li> <li>sources (array)</li> </ol> <p> </p> <ul> <li>annotations-legend.json</li> </ul> <p>This .json file contains entity and entity labels encoded to text legends. For example, entity class label "1_2_Yes_Good" is encoded as "e_113".</p> <p> </p> <p><strong>Resources</strong></p> <p>The code to parse annotations can be found on <a href="http:// https://github.com/anjani-dhrangadhariya">GitHub</a>.</p> <p> </p> <p><strong>Funding</strong></p> <p>HES-SO Valais-Wallis, Sierre, Switzerland</p>
Data from randomized control trials released hatchery salmon treated with anti-parasitic treatment
<p>Data used in the article "<strong>Parasite spillback from fish farms reduce return rate of wild salmon"</strong></p> <p> </p> <p>Each release group has been used as a randomized control trials (RCT) of hatchery reared salmon smolts where half of the fish has been treated with an antiparasitic drug. Description of this method has been given in various other publications (Vollset et al. 2014, Vollset et al 2016, Skilbrei et al. 2013). The method involves rearing salmon eggs originating from the national Gene Bank to smolt size in hatchery facilities during one year, and then treating the salmon smolts with fish feed pellets coated with emamectin benzoate (SLICE®). These fish are then released into the river or transported in tanks or mobile net pens further out in the fjord before release. The fish are tagged with either coded-wire-tags (CWT; years 2000-2017) or Passive Integrated Transponders (PIT; 2015-2019) so that it is possible to identify them as they are recaptured or registered on an antenna upon their return as adults. In a few trials, another antiparasitic treatment (Substance EX) has been used, but in most cases the EB has been the only available treatment. Releases of hatchery reared salmon in freshwater have not been successful in this system, i.e. very few fish have returned from any group released in the river, lakes or estuary of Vosso. Since the release groups are also a part of a restoration effort of the Vosso salmon, some years fish have only been released in the fjord. There has been some variation in the release sites in the fjords, but for the purpose of this study we group the release groups in either group that has been released in the outer fjord (70-105 km from the river mouth) and the inner fjord (15-70 km from the river mouth), and freshwater (approx -10 to 15 km from the river mouth). The two most prevalent locations are at Manger (WGS84; 60.63918, 4.92149) and Arna (WGS84; 60.50812, 5.37777).</p> <p> </p> <p><em>Sea lice surveillance</em></p> <p> </p> <p>Sea lice surveillance on sea trout has been conducted at Herdla, the northern peninsula of the island Askøy (WGS84; 60.568972, 4.963010) since 2009. Here, trout have been caught using a trap net that has been developed specifically to capture and treat trout while minimizing sea lice loss during handling (Barlup et al. 2013). From an earlier study by Vollset et al. (2018), it has been shown that the lice numbers on sea trout on this site correlate with the infestation pressure of fish farms in the outer region of the fjord. This area is also one of the largest fish farm zones with coordinated production and fallowing in the outer fjord system where all the released salmon smolts must migrate (see Vollset et al. 2018). This is also the area where surface salinity layers permit salmon lice to overlap with out-migrating salmon smolts (Vollset et al. 2016).</p> <p> </p> <p>The number of trout caught during the monitoring season has varied with weather conditions, sampling intensity, and number of traps operated. The way that trout are handled is described in more detail in Vollset et al. (2018), but in brief, the trap chambers are checked daily, and individual trout are transferred from the trap using a hand held dip net and are either euthanized and placed in zip-lock bag or transported in a large bucket with aerated water to land. Euthanized samples are kept cold and frozen when at land, and later thawed and counted in the lab, while live samples are counted after being sedated with half dose (0.05 g/L) of MS222 and then assessed for salmon lice in a high-contrast bucket using a headlamp by trained personnel. Since 2015 the sea lice surveillance at Herdla is also operated as a part of the Norwegian national sea lice monitoring program.</p> <p>We aimed to use a standardized time period from which to assess sea lice numbers on sea trout that can be representative of the lice infestation pressure from when the tagged hatchery salmon smolts are released. When counting sea lice on sea trout, the most observable lice are large chalimus and mobile stages, while recently attached copepods are more likely to be missed. Therefore, we use total lice counts on sea trout from Julian day 135 to 165 as an assessment of the infestation pressure the salmon smolts must experience. This corresponds to approximately 15 May to 15 of June, and is based on a study on progression rate of salmon smolts from hatchery smolt in this area (Vollset et al. 2016). To account for the fact that larger fish will attract more parasites, we use parasites per gram fish per individual and average data to get one index per year. This method is expected to provide a fair index of interannual variation of the infestation pressure.</p> <p> </p> <p>Table 1 Description of column names in csv file</p> <table> <tbody> <tr> <td>Name</td> <td>Description</td> </tr> <tr> <td>release_year</td> <td>Year of release as smolts</td> </tr> <tr> <td>release_place</td> <td>Name of release place location</td> </tr> <tr> <td>release_date</td> <td>Date of release as smolts</td> </tr> <tr> <td>Released</td> <td>Number of hatchery smolt released</td> </tr> <tr> <td>Recaptured</td> <td>Number of hatchery smolt recaptured as adults</td> </tr> <tr> <td>treat</td> <td>Treatment (either treatment or control)</td> </tr> <tr> <td>tag</td> <td>Tag type (either CWT or PIT)</td> </tr> <tr> <td>release_category</td> <td>Release place (either river, outer fjord or inner fjord)</td> </tr> <tr> <td>lpg</td> <td>Lice per gram fish on trout during surveillance from 15 of May to 15 of June the year of release</td> </tr> <tr> <td>pr</td> <td>Percent (%) recaptures as adults</td> </tr> </tbody> </table> <p> </p>
Data for Project 'Feasibility, Usability and Acceptance of a Newly Developed Exergame-Based Training Concept for Older Adults with Mild Neurocognitive Disorder - A Pilot Randomized Controlled Trial'
<p>Data for Project 'Feasibility, Usability and Acceptance of a Newly Developed Exergame-Based Training Concept for Older Adults with Mild Neurocognitive Disorder - A Pilot Randomized Controlled Trial' (trial registered at clinicaltrials.gov (<a href="https://clinicaltrials.gov/ct2/show/NCT04996654">NCT04996654</a>; date of registration: 11 July 2021), consisting of:</p> <p>(1) the original and complete data set for all primary outcomes ('Data_Primary-Outcomes_Brain-IT-Pilot-Feasibility-RCT_for-publication.xlsx');</p> <p>(2) the original and complete data set for all secondary outcomes ('Data_Secondary-Outcomes_Brain-IT-Pilot-Feasibility-RCT_for-publication.xlsx');</p> <p>(3) the original and complete data set for all other outcomes (i.e. baseline factors (demographic data, type of usual care interventions) and training heart rate; 'Data_Other-Outcomes_Brain-IT-Pilot-Feasibility-RCT_for-publication.xlsx');</p> <p>(4) folder including the raw and processed heart rate variability (HRV) and electroencephalography (EEG) data for all participants and measurements (HRV-and-EEG_raw-and-processed-data.zip);</p> <p>(5) a corresponding README file including (a) general information, (b) data and file overview, (c) sharing and access information, (d) methodological information, and (e) data-specific information.</p>
Cluster randomized controlled trial evaluating the impact on children's linear growth of an unconditional cash transfer program implemented in rural areas of North Togo
<p>A parallel cluster randomized controlled trial was implemented in North Togo. 162 rural landlocked villages were randomized into either an intervention arm (cash transfers + package of community activities, <em>n</em>=82) or a control arm (package of community activities only, <em>n</em>=80). </p> <p>Two different representative samples of children aged 6-29 months and their mothers were surveyed, one before the intervention (2014, <em>n</em>=2,658), the other two years afterwards (2016, <em>n</em>=2,031).</p> <p>You will found here:</p> <ul> <li>Two datasets, fully anonymized (French, CSV files): one for observations on households and the other for observations on mother-child pairs</li> <li>Two dictionaries of variables (French, Excel files): one for the household database and the other for the mother-child pairs database</li> <li>The study protocol as submitted to the Ministry of Health of Togo (French, PDF)</li> <li>The technical and financial proposal (to evaluate the CT program) as submitted to funders (English, PDF)</li> </ul> <p> </p>
Dataset accompanying the journal article: Bouldering psychotherapy is not inferior to cognitive behavioural therapy in the group treatment of depression: A randomized controlled trial
<p>SPSS-Dataset containing the (not-imputed) raw data for the non-inferiority trial on BPT vs. CBT. All personal data removed. Only data of participants of the CBT or BPT group included.</p>
Dataset of The Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial
<p>This the dataset related to the article entitled "he Relationship Between Postoperative Opioid Analgesia and Sleep Apnea Severity in Patients Undergoing Hip Arthroplasty: A Randomized, Controlled, Triple-Blinded Trial".</p> <p>Purpose: Residual postoperative pain after hip arthroplasty is usually treated with oral opioids. While classic opioids are associated with respiratory depression and worsening of sleep apnea, tramadol has been reported to preserve respiratory function. However, this has not been investigated in a prospective trial using respiratory polygraphy. This randomized controlled triple-blinded trial tested the hypothesis that postoperative treatment with oral opioids such as oxycodone would increase sleep apnea severity, measured with a respiratory polygraphy, compared with oral tramadol.<br> Patients and Methods: Sixty patients undergoing hip arthroplasty under spinal anesthesia with 15 mg isobaric bupivacaine 0.5% were randomized to receive postoperative pain treatment with either oral oxycodone (controlled-release 10 mg every 12 hours and immediate-release 5 mg every 4 hours as needed) or oral tramadol (controlled-release 100 mg every 8 hours and immediate-release 50 mg every 4 hours as needed). Respiratory polygraphy was performed on the first postoperative night. The primary outcome was the apnea-hypopnea index in the supine position. Secondary outcomes included the oxygen desaturation index, postoperative pain scores and intravenous morphine consumption.<br> Results: Mean supine apnea-hypopnea index on postoperative night 1 was 11.3 events.h−1 (95% confidence interval, 4.8–17.7) in the oxycodone group and 10.7 (4.6–16.8) events.h−1 in the tramadol group (p=0.89). There were no significant differences between the oxycodone and tramadol groups with respect to any secondary sleep-related or pain-related outcomes.<br> Conclusion: Oral oxycodone did not increase sleep apnea severity measured using respiratory polygraphy compared with oral tramadol on the first postoperative night after hip arthroplasty.</p>
Early Virtual-Reality-Based Home Rehabilitation after Total Hip Arthroplasty: A Randomized Controlled Trial
<p>The benefits of early virtual-reality-based home rehabilitation following total hip arthroplasty (THA) have not yet been assessed. The aim of this randomized controlled study was to compare the efficacy of early rehabilitation via the Virtual Reality Rehabilitation System (VRRS) versus traditional rehabilitation in improving functional outcomes after THA. Subjects were randomized either to an experimental (VRRS; n = 21) or a control group (control; n = 22). All participants were invited to perform a daily home exercise program for rehabilitation after THA with different administration methods—namely, an illustrated booklet for the control group and a tablet with wearable sensors for the VRRS group. The primary outcome was the hip disability (HOOS JR). Secondary outcomes were the level of independence and the degree of global perceived effect of the rehabilitation program (GPE). Outcomes were measured before surgery (T0) and at the 4th (T1), 7th (T2), and 15th (T3) day after surgery. Mixed-model ANOVA showed no significant group effect but a significant effect of time for all variables (<em>p </em>< 0.001); no differences were observed in HOOS JR between VRRS and the control at T0, T1, T2, or T3. Further, no differences in the level of independence were found between VRRS and the control, whereas the GPE was higher at T3 in VRSS compared to the control (4.76 ± 0.43 vs. 3.96 ± 0.65; <em>p </em>< 0.001). Virtual-reality-based home rehabilitation resulted in similar improvements in functional outcomes with a better GPE compared to the traditional rehabilitation program following THA. The application of new technologies could offer novel possibilities for service delivery in rehabilitation.</p>
Pre- and post-intervention responses to a knowledge, attitudes, and practices survey for the study, "Disseminating vaccination information in baby soap products increases knowledge and vaccine uptake in central Uganda: A non-randomized controlled trial"
<p>This dataset contains responses to the pre- and post-intervention knowledge, attitudes, and practices surveys utilized for the study, "Disseminating vaccination information in baby soap products increases knowledge and vaccine uptake in central Uganda: A non-randomized controlled trial."</p>
Randomized controlled oncology trials with tumor stage inclusion criteria
<p><em>Background:</em></p> <p>Extracting inclusion and exclusion criteria in a structured, automated fashion remains a challenge to developing better search functionalities or automating systematic reviews of randomized controlled trials in oncology. The question "Did this trial enroll patients with localized disease, metastatic disease, or both?" could be used to narrow down the number of potentially relevant trials when conducting a search.</p> <p><em>Dataset collection:</em></p> <p>600 randomized controlled trials from high-impact medical journals were classified depending on whether they allowed for the inclusion of patients with localized and/or metastatic disease. The dataset was randomly split into a training/validation and a test set of 500 and 100 trials respectively. However, the sets could be merged to allow for different splits.</p> <p><em>Data properties:</em></p> <p>Each trial is a row in the csv file. For each trial there is a doi, a publication date, a title, an abstract, the abstract sections (introduction, methods, results, conclusion), several tags associated with the annotation process (text, _input_hash, _task_hash, options, _view_id, config, accept, answer, _timestamp, _annotator_id,_session_id), and the assigned labels (answer).</p>
Effects of personalized music listening on post-stroke cognitive impairment: A randomized controlled trial
<p><strong><span>Background and purpose:</span></strong><span> Previous studies have suggested that music listening has the potential to positively affect mood and cognitive functions in individuals with <a name="_Hlk140153246"></a>post-stroke cognitive impairment (PSCI), with a preference for self-selected music likely to yield better outcomes. However, there is insufficient clinical evidence to suggest the use of music listening in routine rehabilitation care to treat PSCI. This randomized control trial (RCT) aims to investigate the effects of personalized music listening on mood improvement, <a name="_Hlk140153263"></a>activities of daily living (ADLs), and cognitive functions in individuals with PSCI.</span></p> <p><strong><span>Materials and methods:</span></strong><span> A total of 34 patients with PSCI were randomly assigned to either the music group or the control group. Patients in the music group underwent a three-month personalized music-listening intervention. The intervention involved listening to a personalized playlist tailored to each individual's cultural, ethnic, and social background, life experiences, and personal music preferences. In contrast, the control group patients listened to white noise as a placebo. Cognitive function, neurological function, mood, and ADLs were assessed. </span></p> <p><strong><span>Results:</span></strong><strong><span> </span></strong><span>After three months of treatment, the music group showed significantly higher <a name="_Hlk140153278"></a>Montreal Cognitive Assessment (MoCA) scores compared to the control group (<em>p=</em>0.027), particularly in the domains of delayed memory (<em>p=</em>0.019) and orientation (<em>p=</em>0.023). Moreover, the music group demonstrated significantly better scores in <a name="_Hlk140153297"></a>National Institute of Health Stroke Scale (NIHSS) (<em>p=</em>0.008), <a name="_Hlk140153304"></a>Barthel Index (BI) (<em>p=</em>0.019), and <a name="_Hlk140153315"></a>Zarit Caregiver Burden Interview (ZBI) (<em>p=</em>0.008) compared to the control group. No effects were found on mood as measured by the Hamilton Rating Scale for Anxiety (HAMA) and the Hamilton depression scale (HAMD).</span></p>
Figure 1 in A new policy to implement CONSORT guidelines for surgical randomized controlled trials
Figure 1. – Smilosicyopus species (males). A: S. chloe (P. Gaucher); B: S. fehlmanni (P. Keith); C: S. nigriradiatus (P. Keith); D: S. sasali (P. Keith); E: S. pentecost (C. Lord); F: S. bitaeniatus (E. Vigneux); G: S. leprurus (P. Keith).
Dataset related to article "Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke"
<p>https://figshare.com/search?q=10.6084%2Fm9.figshare.21346731</p>
Mechanistic Drivers of Acute PAPE Responsiveness: Muscle Architecture, Contractile Kinetics, and Excitability in a Randomized Controlled Trial
ClinicalTrials.gov study NCT06982937. IPD Sharing: NO. Countries: 1. Publications: 1.
A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Can
ClinicalTrials.gov study NCT02163694. IPD Sharing: YES. Countries: 37. Publications: 5.
The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer
ClinicalTrials.gov study NCT03668223. IPD Sharing: YES. Countries: 1. Publications: 3.
Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program
ClinicalTrials.gov study NCT04317053. IPD Sharing: YES. Countries: 1. Publications: 2.
Fresh Food Farmacy: A Randomized Controlled Trial
ClinicalTrials.gov study NCT03718832. IPD Sharing: YES. Countries: 1. Publications: 1.
Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life Randomized Control Trial
ClinicalTrials.gov study NCT04173572. IPD Sharing: YES. Countries: 1. Publications: 0.
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
ClinicalTrials.gov study NCT01805440. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.