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ShareScore release 0.9.0
Dataset results
41 results for “Ras signaling”
Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase
<p>Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently. We have developed compounds that prevent farnesylation of <em>Cryptoccoccus</em> <em>neoformans</em> Ras protein by inhibiting protein farnesyltransferase with 3–4 nanomolar affinities. Farnesylation directs Ras to the cell membrane and is required for infectivity of this lethal pathogenic fungus. Our high-affinity compounds inhibit fungal growth with 3–6 micromolar minimum inhibitory concentrations, 4- to 8-fold better than Fluconazole, an antifungal commonly used in the clinic. Compounds bound with distinct inhibition mechanisms at two alternative, partially overlapping binding sites, accessed via different inhibitor conformations. We showed that antifungal potency depends critically on the selected inhibition mechanism, because this determines the efficacy of an inhibitor at low <em>in</em> <em>vivo</em> levels of enzyme and farnesyl substrate. We elucidated how chemical modifications of the antifungals encode the desired inhibitor conformation and concomitant inhibitory mechanism.</p>
Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase
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Data from: Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila
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The hippo pathway effector protein YAP modulated resistance to trametinib neuroblastomas with hyperactivated RAS pathway signalling
GEO Series GSE130401. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Ras signaling inhibitors in in Adjuvant-induced Arthritis via targeting pathogenic antigen-specific Th17-type cells
GEO Series GSE100280. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
ETV4 promotes metastasis in response to combined activation of PI3kinase and RAS signaling in a mouse model of advanced prostate cancer
GEO Series GSE47697. Mus musculus. 21 samples. Type: Expression profiling by array.
microRNA-143/145 loss induces Ras-signaling and cooperates with Pten-deficiency to promote basal-like breast cancer [CGH]
GEO Series GSE99495. Mus musculus. 10 samples. Type: Genome variation profiling by array.
Inhibition of EGFR signaling downregulates K-RAS mutated activity
GEO Series GSE113146. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Hippo reprograms the transcriptional response to Ras signalling
GEO Series GSE96868. Drosophila melanogaster. 31 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling
GEO Series GSE59239. Homo sapiens. 14 samples. Type: Genome variation profiling by array.
Ras and TGF-beta signaling aggravates the metastatic and invasive potential of cancer cells through activation of the deltaNp63 alpha transcriptional program
GEO Series GSE60814. Homo sapiens. 13 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling [RNA-seq]
GEO Series GSE105039. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
CUX1 deficiency potentiates RAS signaling to drive malignancy
GEO Series GSE161614. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome of senescence-committed vs uncommitted cells upon oncogenic RAS signaling
GEO Series GSE220545. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq]
GEO Series GSE63497. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing.
RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
GEO Series GSE77843. Mus musculus. 6 samples. Type: Expression profiling by array.
The role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
GEO Series GSE17338. Cryptococcus deneoformans JEC21; Cryptococcus neoformans H99. 18 samples. Type: Expression profiling by array.
RAL GTPases mediate EGFR/MAPK signalling-driven intestinal stem cell proliferation and tumourigenesis upstream of RAS activation.
GEO Series GSE162421. Drosophila melanogaster. 16 samples. Type: Expression profiling by high throughput sequencing.
NF-kB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model
GEO Series GSE291665. Drosophila melanogaster. 3 samples. Type: Expression profiling by high throughput sequencing.
Pan-Raf co-operates with PI3K-dependent signaling and critically contributes to myeloma cell survival independently of mutated RAS
GEO Series GSE75078. Homo sapiens. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.