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2,180 results for “ReCombine”
Raw data to accompany the manuscript 'Data for Engineering Lipid Metabolism of Chinese Hamster Ovary (CHO) Cells for Enhanced Recombinant Protein Production' published in the Journal Data in Brief
<p>This repository consists of the raw western blot, microscopy and mass spectrometry data to accompany the manuscript 'Data for Engineering Lipid Metabolism of Chinese Hamster Ovary (CHO) Cells for Enhanced Recombinant Protein Production' published in the Journal Data in Brief and associated with the article '<a href="https://www.ncbi.nlm.nih.gov/pubmed/31805379">Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production</a>' published in the journal Metabolic Engineering (see DOI: 10.1016/j.ymben.2019.11.007). </p> <p>The western blot raw file is associated with Figure 1a and 1b of the Data in Brief manuscript.</p> <p>The confocal microscopy raw image files (x3) are associated with Figure 1c of the Data in Brief manuscript.</p> <p>The mass spectrometry files are the raw data that refers to the samples presented in Figure 5 of the Data in Brief manuscript. Files are labelled as in the Data in Brief and Metabolic Engineering manuscripts. The file name structures is as follows;</p> <p>CHO-Controlpoolai</p> <p>Where 'a' represents replicate 'a' of three biological replicates and 'i' refers to mass spectrometry technical analysis 1 of 3 technical analyses of each replicate (thus for each cell pool or line there are three biological replicates that are each analysed in triplicate such that there are 9 raw mass spectrometry files for each cell pool or line).</p> <p>All the mass spectrometry files are found in the compressed (zip) file named mass_spectrometry_raw_files_archive.zip</p>
Data from: Sex-specific recombination landscape in a species with holocentric chromosomes
<p>Male and female meiosis typically exhibit significant differences in crossover locations along chromosomes. It has been suggested that higher recombination rates at chromosome centers in females counteract centromere-associated meiotic drivers, increasing their chances of segregating into the oocyte rather than to the non-viable polar bodies. Our research, employing the first sex-specific recombination map for an organism lacking defined centromeres revealed parallel recombination landscapes across the sexes, supporting the meiotic drive hypothesis.</p>
The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high-levels of lineage-specific diversity driven by recombination
<p><em>Aspergillus fumigatus </em>is a deadly agent of human fungal disease, where virulence heterogeneity is thought to be at least partially structured by genetic variation between strains. While population genomic analyses based on reference genome alignments offer valuable insights into how gene variants are distributed across populations, these approaches fail to capture intraspecific variation in genes absent from the reference genome. Pan-genomic analyses based on <em>de novo</em> assemblies offer a promising alternative to reference-based genomics, with the potential to address the full genetic repertoire of a species. Here, we use a combination of population genomics, phylogenomics, and pan-genomics to assess population structure and recombination frequency, phylogenetically structured gene presence-absence variation, evidence for metabolic specificity, and the distribution of putative antifungal resistance genes in <em>A. fumigatus</em>. We provide evidence for three distinct populations of <em>A. fumigatus</em>, structured by both gene variation (SNPs and indels) and distinct gene presence-absence variation with unique suites of accessory genes present exclusively in each clade. Accessory genes displayed functional enrichment for nitrogen and carbohydrate metabolism, hinting that populations may be stratified by environmental niche specialization. Similarly, the distribution of antifungal resistance genes and resistance alleles were often structured by phylogeny. Despite low levels of outcrossing, <em>A. fumigatus</em> demonstrated a large pan-genome including many genes unrepresented in the Af293 reference genome. These results highlight the inadequacy of relying on a single-reference based approach for evaluating intraspecific variation, and the power of combined genomic approaches to elucidate population structure, genetic diversity, and the putative ecological drivers of clinically relevant fungi.</p> <p>Accompanying manuscript is available as preprint at <a href="https://dx.doi.org/10.1101/2021.12.12.472145">https://dx.doi.org/10.1101/2021.12.12.472145</a> </p> <p>Lotus A. Lofgren, Brandon S. Ross, Robert A. Cramer, Jason E. Stajich. Combined Pan-, Population-, and Phylo-Genomic Analysis of <em>Aspergillus fumigatus</em> Reveals Population Structure and Lineage-Specific Diversity bioRxiv 2021.12.12.472145; doi: https://doi.org/10.1101/2021.12.12.472145</p>
Data for the publication: Recombinant silk protein condensates show widely different properties depending on the sample background
<p>This entry includes raw data for the publication "Recombinant silk protein condensates show widely different properties depending on the sample background". The original publication was published in: Journal of Materials Chemistry B, DOI: 10.1039/d4tb01422g</p> <p>The folder "Videos_Micropipette_Aspiration_Zenodo.zip" contains 9 TIF files, labeled Number1 - Number9. The numbering corresponds to the numbering of IMAC condensates studied with micropipette aspiration in the publication. Each TIF file is an image stack from a time series.</p> <p>The folders "Videos_IMAC_silk_with_BG_lysate_coalescence.zip", "Videos_HT_silk_coalescence.zip", and "Videos_IMAC_silk_coalescence.zip" all contain subfolders labeled with the purification method, the framerate of the videos and then consecutive numbering. Each of these folders contains the frames of the video as single TIF files.</p> <p>Please find more information in the read_me file uploaded.</p>
The optimal period for oocyte retrieval after the administration of recombinant human chorionic gonadotropin in in vitro fertilization
<p>This is the dataset of the study called "The optimal period for oocyte retrieval after the administration of recombinant human chorionic gonadotropin in in vitro fertilization".</p> <p><strong>Abstract</strong></p> <p>Background</p> <p>Our objective was to investigate the existence of an optimal period for oocyte retrieval in regards to the clinical pregnancy occurrence after the administration of recombinant human chorionic gonadotropin (rhCG) (Ovitrelle®).</p> <p>Methods</p> <p>We studied the digital records of 3362 middle eastern couples who underwent in vitro fertilization (IVF) treatment between 2019 and 2021.</p> <p>Results</p> <p>Through statistical testing, we found that there is a significant positive correlation between the oocyte retrieval period and the clinical pregnancy occurrence up to the 37th hour, where retrieval at the 37th hour was found to provide the most optimal outcome, especially in the case of gonadotropin-releasing hormone agonist (GnRHa) long protocol.</p> <p>Conclusions</p> <p>This cohort study recommends retrieval at hour 37 after ovulation triggering under the described conditions.</p>
The Cassandra retrotransposon landscape in sugar beet (Beta vulgaris): Recombination and re-shuffling leads to a high structural variability
<p>Here we provide supplementary data for our study of non-autonomous Cassandra terminal-repeat retrotransposons in miniature (TRIMs) in sugar beet and related genomes.</p> <p>Cassandra sequences are distributed across the plant kingdom and share a unique feature: conserved 5S rDNA promoter motifs within their long terminal repeats (LTRs). This dataset contains two multiple sequence alignments and a sequence list of tandemly-arranged (TA) Cassandra sequences in FASTA format. Alignments cover LTR and internal regions of all Amaranthaceae Cassandra (Ama-Cassandra) from our study. This includes Cassandra full-length sequences from <em>B. vulgaris</em> (Ama_Cassandra_Beet_full-length) and <em>C. quinoa</em> (Ama_Cassandra_Quinoa_full-length). Sequence names include information on host plant, subfamily classification, localisation (scaffold), start and stop position, a Lab-unique TE identifier and sequence orientation. For the tandemly-arranged Cassandra sequences from sugar beet, we provide a sequence list of twelve sequences (Ama_Cassandra_TA_Beet_list). Here, sequence names refer to TA copy number, host, localisation (scaffold), start and stop position, a Lab-unique TE identifier and sequence orientation.</p> <p>All sequences were identified in the recent genome assemblys of <em>B. vulgaris</em> (RefBeet1.2; Dohm <em>et al</em>. 2014) and <em>C. quinoa</em> (ASM168347v1; Jarvis <em>et al</em>., 2017).</p>
Recombinant Hepatitis E Viruses Harboring Tags in the ORF1 Protein
<p>Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis and jaundice in the world. Current understanding of the molecular virology and pathogenesis of hepatitis E is incomplete, especially due to the limited availability of functional tools. Here, we report the development of tagged HEV genomes as a novel tool to investigate the viral life cycle. A selectable subgenomic HEV replicon was subjected to random 15-nucleotide sequence insertion using transposon-based technology. Viable insertions in the open reading frame 1 (ORF1) protein were selected in a hepatoblastoma cell line. Functional insertion sites were identified downstream of the methyltransferase domain, in the hypervariable region (HVR) and between the helicase and RNA-dependent RNA polymerase domains. HEV genomes harboring a hemagglutinin (HA) epitope tag or a small luciferase (NanoLuc) in the HVR were found to be fully functional and to allow for the production of infectious virus. NanoLuc allowed to quantitatively monitor HEV infection and replication by luciferase assay. HA-tagged replicons and full-length genomes allowed to localize putative sites of HEV RNA replication by the simultaneous detection of viral RNA by fluorescence in situ hybridization and of ORF1 protein by immunofluorescence. Candidate HEV replication complexes were found in cytoplasmic dot-like structures which partially overlap with ORF2 and ORF3 proteins as well as exosomal markers. Hence, tagged HEV genomes yield new insights into the viral life cycle and should allow to further investigate the structure and composition of the viral replication complex.</p>
Recombination and aneuploidy data for: Insights about variation in meiosis from 31,228 human sperm genomes
<p>This repository holds crossover and aneuploidy data for 31,228 human sperm genomes sequenced with Sperm-seq. Data are described in the preprint/paper "Insights about variation in meiosis from 31,228 human sperm genomes." Several levels of data are available, e.g., each crossover (allcrossovers_hg38.txt.gz) and the numbers of crossovers detected per sperm cell (numbercrossoverspercell.txt.gz). Each data file is described in its own readme, so README_allgainsdivisionoforigin.txt explains the data present in allgainsdivisionoforigin.txt. All files are either text files or text files compressed via gzip. All data was generated as described in the preprint/paper, using scripts available in the companion repository (most recent version DOI: 10.5281/zenodo.3561080).</p> <p>This new version has updated sex chromosome ploidies after identifying a minor coding error affecting ~24 cells (sexchromosomeploidy.txt.gz) and includes more detail about possible crossover error modes (README_allcrossovers_hg38.txt.gz).</p>
Genome data and resources on the recombination landscape and population history of the harlequin fly
<p>This dataset contains phased vcf files of <em>Chironomus riparius, </em>ouput files of RepeatMasker, MELT, RepeatOBserver, MSMC2, iSMC and bedtools, such as supporting files. </p> <p>For further details also check the GitHub page: <a href="https://github.com/lpettrich/Crip_Recombination_PopHistory_Cla_2024" target="_blank" rel="noopener">https://github.com/lpettrich/Crip_Recombination_PopHistory_Cla_2024</a></p> <ul> <li><strong>phased-vcfs: </strong>Artificially phased vcf-files of five populations with four individuals each. Needed to generate multihetsep files. Input files for iSMC.<br> <ul> <li>Hesse in Germany = MG</li> <li>Rhône-Alpes in France = MF</li> <li>Lorraine in France = NMF</li> <li>Piemont in Italy = SI</li> <li>Andalusia in Spain = SS</li> </ul> </li> <li><strong>multihetsep-files: </strong>Created with msmc-tools. Input files for MSMC2. </li> <li><strong>RepeatMasker: </strong>Raw output of RepeatMasker run. Summary file and file with filtered <em>Cla</em>-element (a transposable element) included.<strong><br></strong></li> <li><strong>MELT: </strong>MELT ouput with added info on population and numbered insertions reflecting all 441 detected <em>Cla </em>insertions.<strong><br></strong></li> <li><strong>RepeatOBserver: </strong>Summary files on centromere predictions based on histograms and Shannon Diversity from RepeatOBserver. Genome-wise Shannon Diversity per chromosome included. <strong><br></strong></li> <li><strong>MSMC2: </strong>Raw ouput of combined cross-coalescence and mean values if MSMC2 per populations. <strong><br></strong></li> <li><strong>iSMC: </strong>Recombination rate rho in 10 kb windows and 100 kb windows along the genome. <strong><br></strong></li> <li><strong>bedtools closest ismc 10 kb: </strong>Bedtools closest analysis of the distance of the next <em>Cla</em>-element to the recombination rate rho in 10 kb windows.<strong><br></strong></li> <li><strong>bedtools closest ismc 100 kb: </strong>Bedtools closest analysis of the distance of the next <em>Cla</em>-element to the recombination rate rho in 100 kb windows.</li> <li><strong>input-files figures: </strong>Supporting files needed to create figures.<strong><br></strong></li> </ul>
Evolution of the recombination regulator PRDM9 in minke whales
<p>This data repository contains data and protocols for the manuscript: Evolution of the recombination regulator PRDM9 in minke whales</p>
Dataset for Charge collection efficiency, underlying recombination mechanisms, and the role of electrode distance of vented ionization chambers under ultra-high dose-per-pulse conditions
<p>Dataset for paper: Kranzer et al., <a href="https://www.sciencedirect.com/journal/physica-medica">Physica Medica</a> <a href="https://www.sciencedirect.com/journal/physica-medica/vol/104/suppl/C">Volume 104</a>, December 2022, Pages 10-17</p> <p><a href="https://doi.org/10.1016/j.ejmp.2022.10.021">https://doi.org/10.1016/j.ejmp.2022.10.021</a></p>
Supplementary phylogenetic data for Rouïl et. al. 2020 "The protector within: Comparative genomics of APSE phages across aphids reveals rampant recombination and diverse toxin arsenals"
<p>Supplementary phylogenetic data for Rouïl <em>et. al.</em> 2020 "The protector within: Comparative genomics of APSE phages across aphids reveals rampant recombination and diverse toxin arsenals"</p> <p> </p> <p>The data set consists of the following sub-directories:</p> <p>1) "APSE_conserved_proteins_alns": Single-copy conserved genes codon sequences and alignments in FASTA format.</p> <p>2) "APSE_phylogeny": Files used for APSE phylogenetic and recombination analyses.</p> <p>3) "APSE_reannotations": GenBank-formatted files of the assemblies and re-annotations of APSE phages. Newly-sequenced phages deposited at the European nucleotide Archive are also included. ***New in this version***</p> <p>4) "APSE_toxin_lyzozyme": Files used for APSE toxin-cassette and lyzozyme-related gene phylogenies.</p> <p>5) "Arsenophonus_PHASTER": PHASTER phage annotation output files organised by organisim and contig/scaffold.</p> <p>6) "Hamiltonella_drafts": Newly-sequenced low-coverage draft <em>Hamiltonella</em> genomes in FASTA format.</p> <p>7) "Hamiltonella_phylogeny": files used for <em>Hamiltonella</em> phylogenetic analysis.</p> <p> </p> <p>See enclosed README.txt file for more details.</p> <p> </p> <p>* ver. 1.1.1: Updated annotations for APSE genomes including inteins missing in previous annotation files.</p>
Supplementary datasets: sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data (Ng et al.)
<p>This repository contains data files from the manuscript Ng et al. "sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data".</p> <p><strong>Directories</strong></p> <p>Please untar the sciCSR-data-files.tar.gz archive.</p> <p><em><strong>Folder "Simulated_data"</strong></em></p> <ul> <li>'simulated_IGHC_reads' folder: containing list of simulated data (FASTQ sequence files and aligned BAM files) to test the accuracy of commonly used RNA-seq aligners (STAR, HISAT2) to distinguish sterile and productive heavy-chain transcripts. The code to generate these data is in the repository https://github.com/Fraternalilab/sciCSR-analysis.</li> <li>'simulated_transitions.RData': .RData file containing list of Seurat objects of simulated datasets of different number of cells, to test the robustness of sciCSR-inferred transitions across different dataset sizes.</li> </ul> <p><em><strong>Folder "Seurat_objects"</strong></em></p> <ul> <li>'human_Bcells_atlas_IGHC_NMF_rank.rds': Nonnegative matrix factorization (NMF) results to derive isotype signatures from the human B cell atlas (see below).</li> <li>'mouse_Bcells_atlas_IGHC_NMF_rank.rds': NMF results to derive isotype signatures from the mouse B cell atlas (see below)</li> <li>'Human_Bcells_atlas_IGHC.rds': Seurat object containing cells forming the 'human B cell atlas' (i.e. merging data from Stewart et al (https://doi.org/10.3389/fimmu.2021.602539) and King et al (https://doi.org/10.1101/2020.04.28.054775))</li> <li>'mouse_Bcells_atlas_IGHC.rds': Seurat object containing cells forming the 'mouse B cell atlas' (i.e. merging data from Mathew et al (https://doi.org/10.1016/j.celrep.2021.109286) and Luo et al (https://doi.org/10.1186/s13578-022-00795-6))</li> <li>'Stewart_HumanPeripheral_Bcells_IGHC.rds': Seurat object containing cells from the Stewart et al (https://doi.org/10.3389/fimmu.2021.602539) peripheral blood B cell atlas.</li> <li>* 'King_HumanTonsil_Bcells_IGHC.rds': Seurat object containing cells from the King et al. (https://doi.org/10.1101/2020.04.28.054775) human tonsilar B cell atlas.</li> <li>'Kim_Covid_Bcells_IGHC.rds': Seurat object containing cells from the Kim et al. (https://doi.org/10.1038/s41586-022-04527-1) time-course scRNA-seq data on human B cell response to SARS-CoV-2 vaccine.</li> <li>'Gomez_AID_VDJ_IGHC.rds': Seurat object containing cells from the Gómez-Escolar et al. (https://doi.org/10.15252/embr.202255000) Aicda mouse knockout scRNA-seq data.</li> <li>'Hong_IL23_Bcells_IGHC.rds': Seurat object containing cells from the Hong et al. (https://doi.org/10.4049/jimmunol.2000280) Il23 p19 mouse knockout scRNA-seq data.</li> <li>'scIFNg.rds': Seurat object containing scRNA-seq data of time-course in vitro culture of B cells stimulated with interferon gamma generated in this work.</li> </ul>
Recombination detection program (RDP4) results for ICMV and SLCMV DNA-B
<p>A DNA-B multiple alignment (Zenodo record 3964977) was scanned with RDP4.100 (D. Martin et al. 2015). Recombination breakpoints for events with statistical support from at least 5 of 7 methods were adjusted per the manual (high-confidence accepted events). A CSV file with the results for the accepted events was exported and then saved a second time with Excel to normalize format (a comma in between every column).</p> <p>Note added 2020-09-07: AJ575821 is listed in the files as ICMV based on its assignment in the NCBI Taxonomy database (taxa 341701 and 31600) but it is better classified as SLCMV.</p> <p>These results will be described in a manuscript by Crespo-Bellido et al.</p>
X-ray diffraction images for human recombinant 5-aminolevulinic acid dehydratase (ALAD).
<p>X-ray diffraction images for recominant human 5-aminolevulinic acid dehydratase (ALAD) collected at ESRF (Grenoble) beam line ID14-2 using an ADSC Quantum 4 detector to a resolution of 2.8 Å. A series of 1 ̊ oscillation images were recorded with an exposure time of 10 seconds per image. More details are given with the scanned notes and the log file. </p>
Comparing photoelectrochemical water oxidation, recombination kinetics and charge trapping in the three polymorphs of TiO2
<p>Please find the TA data sets and the model calculation of rutile attached. Note that the data is normalised to the amplitude at 100 us.</p>
Raw Genotyping data from: Variation in recombination rate and its genetic determinism in sheep populations from combining multiple genomewide datasets
<p>Data supporting :</p> <p><strong>Variation in recombination rate and its genetic determinism in sheep populations from combining multiple genomewide datasets</strong></p> <p>Morgane Petit, Jean-Michel Astruc, Julien Sarry, Laurence Drouilhet, Stephane Fabre, Carole Moreno, Bertrand Servin</p> <p>http://doi.org/10.1534/genetics.117.300123</p> <p><strong>Abstract</strong></p> <p>Recombination is a complex biological process that results from a cascade of multiple events during meiosis. Understanding the genetic determinism of recombination can help to understand if and how these events are interacting. To tackle this question, we studied the patterns of recombination in sheep, using multiple approaches and datasets. We constructed male recombination maps in a dairy breed from the south of France (the Lacaune breed) at a fine scale by combining meiotic recombination rates from a large pedigree genotyped with a 50K SNP array and historical recombination rates from a sample of unrelated individuals genotyped with a 600K SNP array. This analysis revealed recombination patterns in sheep similar to other mammals but also genome regions that have likely been affected by directional and diversifying selection. We estimated the average recombination rate of Lacaune sheep at 1.5 cM/Mb, identified about 50,000 crossover hotspots on the genome and found a high correlation between historical and meiotic recombination rate estimates. A genome-wide association study revealed two major loci affecting inter-individual variation in recombination rate in Lacaune, including the <em>RNF212</em> and<em> HEI10</em> genes and possibly 2 other loci of smaller effects including the <em>KCNJ15</em> and <em>FSHR</em> genes. Finally, we compared our results to those obtained previously in a distantly related population of domestic sheep, the Soay. This comparison revealed that Soay and Lacaune males have a very similar distribution of recombination along the genome and that the two datasets can be combined to create more precise male meiotic recombination maps in sheep. Despite their similar recombination maps, we show that Soay and Lacaune males exhibit different heritabilities and QTL effects for inter-individual variation in genome-wide recombination rates.</p> <p> </p> <p>Data files are provided in Plink format ( https://www.cog-genomics.org/plink2 ).</p> <p> </p>
Transient Optoelectronic Analysis of the Impact of Material Energetics and Recombination Kinetics on the Open-Circuit Voltage of Hybrid Perovskite Solar Cells
<p>This is the data presented in the article 'Transient Optoelectronic Analysis of the Impact of Material Energetics and Recombination Kinetics on the Open-Circuit Voltage of Hybrid Perovskite Solar Cells' published in The Journal of Physical Chemistry C, DOI: 10.1021/acs.jpcc.7b02411.</p>
Reproduction package for "Recombination of localized quasiparticles in disordered superconductors"
<p>This is a reproduction package to the paper "Recombination of localized quasiparticles in disordered superconductors". It contains all data and code to reproduce the figures in this paper.</p>
Fine-scale map reveals highly variable recombination rates associated with genomic features in the Eurasian blackcap
<p>This project estimates historical recombination rates of the Eurasian blackcap (<em>Sylvia atricapilla</em>) and the garden warbler (<em>Sylvia borin)</em> using a linkage disequilibrium-based approach. The population-scaled recombination rates were inferred using 'pyrho' considering the population's demographic information and mutation rates. The mutation rate was taken from a closely related species (flycatcher, <em>Ficedula albicollis</em>).</p> <p>Here we report the recombination rate per site per generation (r, output of pyrho) for all the chromosomes along the genome for both species. </p> <p>Blackcap dataset file: WholeGenome_chromosomes_blackap_n38_Pen20_W50.gz</p> <p>Garden warbler dataset file: WholeGenome_chromosomes_SylBor_n10_Pen20W50.gz</p> <p> </p> <p>Additionally, we annotated the blackcap genome to evaluate the association between recombination rates and specific annotation features (e.g., genes, transcription start sites, promoters, 5'UTR, and 3'UTR regions). The annotation of the genome was based on RNA-seq and Iso-Seq data. It can be found with the name bSylAtr1.1.gff.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.