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35 results for “Reconsolidation”
Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments
ClinicalTrials.gov study NCT01490697. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study
ClinicalTrials.gov study NCT02789982. IPD Sharing: YES. Countries: 2. Publications: 2.
Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence
ClinicalTrials.gov study NCT00916721. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
ClinicalTrials.gov study NCT01449955. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
ClinicalTrials.gov study NCT04468360. IPD Sharing: NO. Countries: 1. Publications: 23.
Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
ClinicalTrials.gov study NCT01713556. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Games on Memory Reconsolidation and Trauma Symptoms
ClinicalTrials.gov study NCT06129435. IPD Sharing: NO. Countries: 1. Publications: 12.
Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma
ClinicalTrials.gov study NCT04982211. IPD Sharing: NO. Countries: 1. Publications: 6.
Extinction Updating in Reconsolidation
ClinicalTrials.gov study NCT02154685. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of CBD Oil on Memory Reconsolidation and Trauma-Related Symptoms
ClinicalTrials.gov study NCT05892276. IPD Sharing: NO. Countries: 1. Publications: 3.
The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol
ClinicalTrials.gov study NCT03151681. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain
ClinicalTrials.gov study NCT05085782. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Imagery Rescripting With and Without Reconsolidation Disruption
ClinicalTrials.gov study NCT06537284. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Impact of CBD-Rich Oil on Aversive Memory Reconsolidation
ClinicalTrials.gov study NCT04726475. IPD Sharing: NO. Countries: 1. Publications: 4.
Reducing Reconsolidation of Trauma Memories With Propranolol
ClinicalTrials.gov study NCT01349439. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation
<p>Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we extend the understanding of the mechanisms implicated in reconsolidation-resistant memories by<i> </i>investigating the hypothesis that specific modulatory signals shape memory formation into a state that lacks lability. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala. Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to post-reactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC.</p>
Data from: Disruption of memory reconsolidation erases a fear memory trace in the human amygdala: An 18-month follow-up
Fear memories can be attenuated by reactivation followed by disrupted reconsolidation. Using functional magnetic resonance imaging we recently showed that reactivation and reconsolidation of a conditioned fear memory trace in the basolateral amygdala predicts subsequent fear expression over two days, while reactivation followed by disrupted reconsolidation abolishes the memory trace and suppresses fear. In this follow-up study we demonstrate that the behavioral effect persists over 18 months reflected in superior reacquisition after undisrupted, as compared to disrupted reconsolidation, and that neural activity in the basolateral amygdala representing the initial fear memory predicts return of fear. We conclude that disrupting reconsolidation have long lasting behavioral effects and may permanently erase an amygdala-dependent fear memory.
Targeting Reconsolidation to Prevent Return of Fear
ClinicalTrials.gov study NCT01623830. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
ClinicalTrials.gov study NCT01822587. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.