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43 results for “Renin-angiotensin system”
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
<p>The behavior of the comprehensive circulating renin‐angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before the onset of congestive heart failure remains largely unexplored.</p> <p>Hypothesis/Objectives: The classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.</p> <p>Animals: One hundred seventeen client‐owned dogs (normal = 60; B1 = 31; B2 = 26).</p> <p>Methods: Prospective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE, ACE2) and renin activity surrogates were calculated from AP concentrations. Equilibrium dialysis (ED) and immediate protease inhibition (PI) methods of AP quantification were compared in 14 healthy dogs.</p> <p>Results: Core RAS activity and aldosterone concentrations did not differ among the 3 groups. However, the balance between the alternative and classical RAS differed, with dogs with stage B2 MMVD having significantly higher ACE2 activity surrogate (ACE2surr) when compared to normal dogs (adjusted P = .02; ratio of medians for ACE2surr [B2:normal], 1.89; 95% confidence interval [CI]: 1.4‐2.6). The ED and PI methods of AP quantification were highly correlated (AngI, r = .9, P < .0001; AngII, r = .8, P = .001).</p> <p>Conclusions and Clinical Importance: Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.</p>
The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
ClinicalTrials.gov study NCT00264641. IPD Sharing: NO. Countries: 1. Publications: 3.
The Effect of Paricalcitol Capsules on Reducing Albuminuria in Patients With Type 2 Diabetic Nephropathy Being Treated With Renin-angiotensin System Inhibitors
ClinicalTrials.gov study NCT00421733. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
ClinicalTrials.gov study NCT00685945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
Open the record for dataset details and reuse information.
Renin-Angiotensin System Inhibitors and COVID-19
ClinicalTrials.gov study NCT04331574. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of Adding Renin-Angiotensin System Inhibitors to Standard Antidiabetic Therapy on Glycemic Control in Patients With Type 2 Diabetes Ellitus
ClinicalTrials.gov study NCT04707508. IPD Sharing: NO. Countries: 1. Publications: 5.
A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors
ClinicalTrials.gov study NCT00920764. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy
ClinicalTrials.gov study NCT06093971. IPD Sharing: NO. Countries: 1. Publications: 1.
Renin-angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation (RASTAVI)
ClinicalTrials.gov study NCT03201185. IPD Sharing: Not stated. Countries: 1. Publications: 31.
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)
ClinicalTrials.gov study NCT03317925. IPD Sharing: NO. Countries: 1. Publications: 45.
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
ClinicalTrials.gov study NCT00901719. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Discontinuing Renin-angiotensin System Inhibitors in Patients With and Without COVID-19
ClinicalTrials.gov study NCT04351581. IPD Sharing: NO. Countries: 1. Publications: 5.
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
ClinicalTrials.gov study NCT04752293. IPD Sharing: YES. Countries: 1. Publications: 79.
Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery
ClinicalTrials.gov study NCT03374449. IPD Sharing: NO. Countries: 1. Publications: 9.
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
ClinicalTrials.gov study NCT03310684. IPD Sharing: NO. Countries: 1. Publications: 20.
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension
ClinicalTrials.gov study NCT02832973. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Study of Renin-angiotensin System in Mechanically Ventilated Subjects
ClinicalTrials.gov study NCT03212690. IPD Sharing: YES. Countries: 1. Publications: 0.
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)
ClinicalTrials.gov study NCT01328769. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension
ClinicalTrials.gov study NCT00498433. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.