Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
308
datasets available to search
ShareScore release 0.9.0
Dataset results
308 results for “Rhesus Macaque”
Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques - dataset
<p>Dataset from Tuyishime M, Spreng RL, et al. Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques. Frontiers in Immunology 2023 doi: 10.3389/fimmu.2023.1260377</p>
Genetic architecture of immune cell DNA methylation in the rhesus macaque
<p><strong>Complete model outputs from rhesus macaque (<em>Macaca mulatta</em>) whole blood meQTL and eQTL analyses in article, "Genetic architecture of immune cell DNA methylation in the rhesus macaque". </strong></p> <p><strong><em>cis</em> meQTL model output (SNP-CpG associations):</strong> </p> <ol> <li>IMAGE_573_meqtl_model_res_wPVE.txt: <ul> <li>Model results from IMAGE meQTL mapping including all genome, chromatin state annotations, and PVE estimates</li> </ul> </li> <li>pqlseq_allimagesnps_res_converged_wpve.txt: <ul> <li>Model results from PQLseq meQTL mapping including PVE estimates </li> </ul> </li> </ol> <p><strong><em>cis</em> eQTL model output (SNP-gene associations): </strong></p> <ol> <li>eqtl_res_sva5_gemma_172samples_qvalue.txt: <ul> <li>Model results from GEMMA eQTL mapping </li> </ul> </li> </ol> <p> </p>
No evidence that grooming is exchanged for coalitionary support in the short- or long-term via direct or generalized reciprocity in unrelated rhesus macaques
<p>Reciprocity is a prominent explanation for cooperation between non-kin. Studies seeking to demonstrate reciprocity often focus on direct reciprocity in the timescale of minutes to hours, whereas alternative mechanisms like generalised reciprocity and the possibility of reciprocation over longer timescales of months and years are less often explored. Using a playback experiment, we tested for evidence of direct and generalised reciprocity, across short and longer timescales. We examined the exchange of grooming for coalitionary support between female rhesus macaques in a population with a complete genetic pedigree. Females that received grooming were not more responsive to calls for coalitionary support from female groupmates compared to control females that received agonism or no interaction – even when the call belonged to a females' most recent grooming partner. Similarly, females were not more responsive to calls for support from their most frequent grooming partner of the last two years, nor if they received large amounts of grooming from all other females in their group. We interpret these results as an absence of evidence for direct or generalised reciprocity on any timescale in the exchange of grooming for coalitionary support in rhesus macaques. If grooming is exchanged for support in this population, it is with an intensity below our ability to detect or over a longer timescale than we examined. We propose by-product explanations may be responsible and highlight the importance of investigating multiple mechanisms when testing apparently cooperative behaviours.</p>
Rhesus macaque cone ratio heritability
<p><span>A defining feature of catarrhine primates is uniform trichromacy – the ability to distinguish red (long; L), green (medium; M), and blue (short; S) wavelengths of light. While the tuning of photoreceptors is conserved, the ratio of L:M cones in the retina is variable within and between species, with human cone ratios differing from other catarrhines. Yet, the sources and structure of variation in cone ratios are poorly understood, precluding a broader understanding of color vision variability. Here, we report a large-scale study of a pedigreed population of macaques. We collected foveal RNA and analysed opsin gene expression using cDNA. We estimated the additive genetic variance of cone ratios. The average L:M ratio and standard error was 1.03:1± 0.02. There was no age effect, and genetic contribution to variation was negligible. We found marginal sex effects with females having larger ratios than males. S cone ratios (0.143: 1± 0.002) had significant genetic variance with a heritability estimate of 43% but did not differ between sexes or age groups. Our results contextualize the derived human condition of L-cone dominance and provide new information about the heritability of cone ratios and variation in primate color vision.</span></p>
Fig. 6 in Gastro-intestinal parasites of urban rhesus macaques (Macaca mulatta) in the Kathmandu Valley, Nepal
Fig. 6. The prevalence of parasites is examined in relation to a) location and b) season. Multicolor triangles and circles in the plots represent individual data points (triangles) and centroid of each specific grouping factor (circle).
Fig. 3 in Gastro-intestinal parasites of urban rhesus macaques (Macaca mulatta) in the Kathmandu Valley, Nepal
Fig. 3. Photomicrographs of various GI parasites of the rhesus macaques at 400×: Trophozoite of E. histolytica (A), Cyst of E. histolytica (B), Cyst of E. coli (C), Cyst of Iodomoeba butschlii (D), Cyst of Giardia spp. (E), Trophozoite of Balantioides coli (F), Cyst of Balantioides coli (G), Egg of Trichuris spp. (H), Egg of Strongyloides spp. (I), Larva of Strongyloides spp. (J), Egg of Hookworm (K), Egg of Trichostrongylus spp. (L), Egg of Ascarid spp. (M), Egg of Physaloptera spp. (N), Egg of Toxocara spp.(O), Egg of Toxocara spp. (P), Egg of Strongyle spp. (Q), Egg of Strongyle spp.(R), Oocyst of Cryptosporidium spp. (S), Unknown spp. 1 (T).
Fig. 1 in Gastro-intestinal parasites of urban rhesus macaques (Macaca mulatta) in the Kathmandu Valley, Nepal
Fig. 1. Map showing the four fecal collection sites of the urban rhesus macaques in the Kathmandu Valley.
Fig. 3 in Prevalence and new genotypes of Enterocytozoon bieneusi in wild rhesus macaque (Macaca mulatta) in China: A zoonotic concern
Fig. 3. Sequence variation in the ITS region of the rRNA gene of Enterocytozoon bieneusi isolates from rhesus macaque. The ITS sequences of 5 known genotypes (D, PL9, CAF4, EbpC, and SCC-2) and 8 novel genotypes (Mul6 to 13) identified in this study, were aligned with each other. The dots and transverse lines indicate base identities and deletions, respectively, relative to the ITS sequence of genotype D.
Fig. 2. Phylogenetic relationship among the Enterocytozoon bieneusi groups. The relationship between the E in Prevalence and new genotypes of Enterocytozoon bieneusi in wild rhesus macaque (Macaca mulatta) in China: A zoonotic concern
Fig. 2. Phylogenetic relationship among the Enterocytozoon bieneusi groups. The relationship between the E. bieneusi genotypes identified in this study and other known genotypes deposited in GenBank was inferred by neighbor-joining analysis of ITS sequences based on genetic distance using the Kimura-2-parameter model. The numbers on the branches represent percent bootstrapping values from 1000 replicates, with more than 50% shown in the tree. Each sequence is identified by its accession number, genotype designation, and host origin. Genotypes marked with black dot are identified in this study.
Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques
<p>Data for: Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques</p> <p>Patterson, S.K., Andonov, E., Arre, A.M., Martinez, M.I., Negron-Del Valle, J.E., Petersen, R.M, Phillips, D., Rahman, A., Ruiz-Lambides, A., Villanueva, I., Lea, A.J., Snyder-Mackler, N., Brent, L.J., Higham, J.P. "Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques." 2024. <em>Philosophical Transactions B. </em></p> <p> </p>
Rhesus macaque cone ratio heritability
Open the record for dataset details and reuse information.
No evidence that grooming is exchanged for coalitionary support in the short- or long-term via direct or generalized reciprocity in unrelated rhesus macaques
Open the record for dataset details and reuse information.
Rhesus Macaque SNP Calls VCFs
<p>Bgzipped vcf and tabix index files of rhesus macaque SNP calls of 150 individuals on the rheMac8 assembly. The samples are all males from the Tulane National Primate Research Center.</p>
Prosocial Decisions in Rhesus Macaques
<p>The spreadsheet contains the performance of animals tested in various experimental conditions of two social studies.</p> <p>Version 2 contains a correction for performance of animal S1 in study 2a that were in the original document partially implemented as percentage of trials rather than number of trial.</p>
Data from: Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta
<p>Cortisol expression has been demonstrated to have variation across development in rhesus macaques (Macaca mulatta). There exists contradictory evidence for the nature of this change, and age at which it occurs, across biological sample types. Consequently, we lack a cohesive understanding for cortisol concentrations across the development of a major human health translational model. We examined hair cortisol concentrations over the first three years of life for 49 mother-reared infant macaques from mixed-sex outdoor units at the California National Primate Research Center. For 48 of these subjects at infancy, one year, and two years, we obtained plasma cortisol samples for: response to a stressor, adjustment to prolonged stress, and response to dexamethasone injection. Hair cortisol concentrations decreased dramatically between three and ten months, followed by relative stability up to the final sampling event at around 34 months of age. Plasma cortisol showed within-year consistency, and consistency between infancy and year one. We document variability in the infant plasma cortisol samples, especially in percent change between samples one and two. Our plasma cortisol results indicate that infants possess the physiological capacity to effectively inhibit the release of cortisol when stimulated, as effectively as later responses in juveniles. Age-related changes in hair cortisol parallel findings indicating a large decline in the weeks following postparturation.</p>
Data from: Social stability via management of natal males in captive rhesus macaques (Macaca mulatta)
<p>Keystone individuals are expected to disproportionately contribute to group stability. For instance, rhesus macaques (<em>Macaca mulatta</em>) who police conflict contribute towards stability. Not all individuals' motivations align with mechanisms of group stability. In wild systems, males typically disperse at maturity and attempt to ascend via contest competition. In a captive system, dispersal is not naturally enabled – individuals attempt to ascend in their natal groups, which can be enabled by matrilineal kin potentially destabilizing group dynamics. We relocated select high-ranking natal males from five groups and assessed group stability before and after. We quantified hierarchical metrics at the individual and group level. After removal, we found significantly higher aggression against the established hierarchy (reversals), indicative of opportunistic attempts to change the hierarchy. Mixed-sex social signaling became more hierarchical, but the strength of this effect varied. Stable structure was not uniformly reached across the groups and alpha males did not all benefit. Indiscriminate natal male removal is an unreliable solution to group instability. Careful assessment of how natal males are embedded within their group is necessary to balance individual and group welfare.</p>
Impact of maternal obesity on the gestational metabolome and infant metabolome, brain, and behavioral development in rhesus macaques
<p>Maternal gestational obesity is associated with elevated risks for neurodevelopmental disorder, including autism spectrum disorder. However, the mechanisms by which maternal adiposity influences fetal developmental programming remain to be elucidated. We aimed to understand the impact of maternal obesity on the metabolism of both pregnant mothers and their offspring, as well as on metabolic, brain, and behavioral development of offspring by utilizing metabolomics, protein, and behavioral assays in a non-human primate model. We found that maternal obesity was associated with elevated inflammation and significant alterations in metabolites of energy metabolism and one-carbon metabolism in maternal plasma and urine, as well as in placenta. Infants born to obese mothers were significantly larger at birth compared to those born to lean mothers. Additionally, they exhibited significantly reduced novelty preference and significant alterations in their emotional response to stress situations. These changes coincided with differences in phosphorylation of enzymes in the brain mTOR signaling pathway between infants born to obese and lean mothers and correlated with the concentration of maternal plasma betaine during pregnancy. In summary, gestational obesity significantly impacted the infant systemic and brain metabolome and adaptive behaviors.</p>
Greater variability in rhesus macaque (Macaca mulatta) endocranial volume among males than females
<p>The greater male variability (GMV) hypothesis proposes that traits are more variable among males than females, and is supported by numerous empirical studies. Interestingly, GMV is also observed for human brain size and internal brain structure, a pattern which may have implications for sex-biased neurological and psychiatric conditions. A better understanding of neuroanatomical variability in nonhuman primates may illuminate whether certain species are appropriate models for these conditions. Here, we tested for sex differences in the variability of endocranial volume (ECV, a proxy for brain size) in a sample 542 rhesus macaques (Macaca mulatta) from a large pedigreed free-ranging population. We also examined the components of phenotypic variance (additive genetic and residual variance) to tease apart the potential drivers of sex differences in variability. Our results suggest that males exhibit more variable ECVs, and that this pattern reflects either balancing/disruptive selection on male behaviour (associated with alternative male mating strategies) or sex chromosome effects (associated with mosaic patterns of X chromosome gene expression in females), rather than extended neurodevelopment among males. This represents evidence of GMV for brain size in a nonhuman primate species and highlights the potential of rhesus macaques as a model for sex-biased brain-based disorders.</p>
Data from: Differential effects of early life adversity on male and female rhesus macaque lifespan
<p>Early life adversity predicts shorter adult lifespan in several animal taxa. Yet, work on long-lived primate populations suggests the evolution of mechanisms that contribute to resiliency and long lives despite early life insults. Here, we tested associations between individual and cumulative early life adversity and lifespan on rhesus macaques at the Cayo Santiago Biological Field Station using 50 years of demographic data. We performed sex-specific survival analyses at different life stages to contrast short-term effects of adversity (i.e., infant survival) with long-term effects (i.e., adult survival). Female infants showed vulnerability to multiple adversities at birth, but affected females who survived to adulthood experienced a reduced risk later in life. In contrast, male infants showed vulnerability to a lower number of adversities at birth, but those who survived to adulthood were negatively affected by both early life individual and cumulative adversity. Our study shows profound immediate effects of insults at birth on female infant cohorts and suggests that affected female adults are more robust. In contrast, adult males who experienced harsh conditions early in life showed an increased mortality risk at older ages as expected from hypotheses within the life course perspective. Our analysis suggests sex-specific selection pressures on life histories and highlights the need for studies addressing the effects of early life adversity across multiple life stages.</p>
Rhesus Macaque SNP Calls VCF
<p>Bgzipped vcf and tabix index files of rhesus macaque SNP calls of 526 individuals on the rheMac8 assembly.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.