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2,461 results for “Rheumatoid Arthritis”
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes - Supplementary Figure 4 representative histology images
<p>This includes the original full-size representative histology images presented in Supplementary Fig. 4 for the paper "Zhang*, Jonsson*, Nathan*, Millard*, et al, Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes, Nature, 2023<strong>"</strong>.</p> <p>Representative fragments from patients in each CTAP, showing composite and individual staining of each marker in the lymphocyte panel or stromal cell panel. A total of 150 fragments from 36 individuals (mean 4.2 fragments per individual, range 2-9 fragments per individual) were stained in batches and analyzed as a single cohort.</p>
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
ClinicalTrials.gov study NCT02332590. IPD Sharing: YES. Countries: 15. Publications: 12.
Comorbidities and Outcomes in Early Rheumatoid Arthritis
ClinicalTrials.gov study NCT03675516. IPD Sharing: NO. Countries: 1. Publications: 3.
AMG 162 (Denosumab) Phase 3 Study (DESIRABLE Study) in Participants With Rheumatoid Arthritis on Disease-modifying Antirheumatic Drugs (DMARDs) Treatment
ClinicalTrials.gov study NCT01973569. IPD Sharing: YES. Countries: 1. Publications: 2.
An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Adults With Rheumatoid Arthritis
ClinicalTrials.gov study NCT02049138. IPD Sharing: YES. Countries: 18. Publications: 3.
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
ClinicalTrials.gov study NCT01146652. IPD Sharing: YES. Countries: 40. Publications: 5.
Accompanied data files used in the paper "Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis"
<p>lists of source file used in the paper "Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis" by Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P Morris, Antony Adamson, Peter Fraser, Magnus Rattray & Stephen Eyre. The paper has been accepted by Nature Communications.</p>
Data from: Large-scale meta-analysis on rheumatoid arthritis across East Asian and European populations
<p><span><span><span><b>Objective:</b> Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes have been identified by population-based genetic association studies, suggesting a large number of undiscovered variants behind a highly polygenic genetic architecture of RA. Here, we performed the largest-ever trans-ancestral meta-analysis with the aim to identify new RA loci and to better understand RA biology underlying genetic associations.</span></span></span></p> <p><span><span><span><b>Methods:</b> Genome-wide RA association summary statistics in three large case-control collections consisting of 311,292 individuals of Korean, Japanese, and European populations were used in an inverse-variance-weighted fixed-effects meta-analysis. Several computational analyses using public omics resources were conducted to prioritize causal variants and genes, RA variant-implicating features (tissues, pathways, and transcription factors), and potentially repurposable drugs for RA treatment. </span></span></span></p> <p><span><span><span><b>Results:</b> We identified 11 new RA susceptibility loci that explained 6.9% and 1.8% of the SNP-based heritability in East Asians and Europeans, respectively, and confirmed 71 known non-HLA susceptibility loci, identifying 90 independent association signals. The RA variants were preferentially located in binding sites of various transcription factors and in cell type-specific transcription-activation histone marks that simultaneously highlighted the importance of CD4<sup>+</sup> T-cell activation and the potential role of non-immune organs in RA pathogenesis. A total of 615 plausible effector genes, based on gene-based associations, expression-associated variants, and chromatin interaction, included targets of drugs approved for RA treatments and potentially repurposable drugs approved for other indications.</span></span></span></p> <p><span><span><span><b>Conclusion:</b> Our findings provide useful insights regarding RA genetic etiology and variant-driven RA pathogenesis.</span></span></span></p>
Data from: Multi-omics analyses on rheumatoid arthritis in CD4+ T cells
<p><strong>Objective</strong>: CD4+ T cells have been suggested as the most disease-relevant cell type in rheumatoid arthritis (RA) in which RA-risk non-coding variants exhibit allele-specific effects on regulation of RA-driving genes. This study aimed to understand RA-specific signatures in CD4+ T cells using multi-omics data, interpreting inter-omics relationships in shaping the RA transcriptomic landscape.</p> <p><span><span><span><b>Methods</b>: We profiled genome-wide variants, gene expression, and DNA methylation in CD4<sup>+</sup> T cells from 82 RA patients and 40 healthy controls using high-throughput technologies. We investigated differentially expressed genes (DEGs) and differentially methylated regions (DMRs) in RA and localized quantitative trait loci (QTLs) for expression and methylation. We then integrated these based on individual-level correlations to inspect DEG-regulating sources and investigated the potential regulatory roles of RA-risk variants by a partitioned-heritability enrichment analysis with RA genome-wide association summary statistics.</span></span></span></p> <p><span><span><span><b>Results</b>: A large number of RA-specific DEGs were identified (n=2,575), highlighting T-cell differentiation and activation pathways. RA-specific DMRs, preferentially located in T-cell regulatory regions, were correlated with the expression levels of 548 DEGs mostly in the same topologically associating domains. In addition, expressional variances in 771 and 83 DEGs were partially explained by expression QTLs for DEGs and methylation QTLs for DEG-correlated DMRs, respectively. A large number of RA variants were moderately to strongly correlated with meQTLs. DEG-correlated DMRs, enriched with meQTLs, had strongly enriched heritability of RA.</span></span></span></p> <p><span><span><span><b>Conclusion</b>: Our findings revealed that the methylomic changes, driven by RA heritability-explaining variants, shape the differential expression of a substantial fraction of DEGs in CD4<sup>+</sup> T cells in RA patients, reinforcing the importance of a multi-dimensional approach in disease-relevant tissues.</span></span></span></p>
Data Integration to Identify and Prioritize Potential Regulatory Variants for Rheumatoid Arthritis in a Post-GWAS era
<p>The Data set contain data related to the SNPs in linkage disequilibrium with published GWAS rheumatoid arthritis SNPs and the subsequent annotation and pathway analysis files performed to identify putative 'missed' variants of rheumatoid arthritis. </p>
A Non-Interventional Study in Rheumatoid Arthritis Patients Treated With Tocilizumab (RoActemra/Actemra)
ClinicalTrials.gov study NCT01613378. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study for Patients With Active Rheumatoid Arthritis Despite Ongoing Methotrexate Therapy
ClinicalTrials.gov study NCT00785928. IPD Sharing: Not stated. Countries: 12. Publications: 1.
Study for Validation of Standardized Questionnaires on Depression and Investigation of the Frequency of Depression in Rheumatoid Arthritis (RA) Participants
ClinicalTrials.gov study NCT02485483. IPD Sharing: Not stated. Countries: 1. Publications: 2.
BI 695501 Compared to Adalimumab in Patients With Active Rheumatoid Arthritis
ClinicalTrials.gov study NCT02137226. IPD Sharing: Not stated. Countries: 15. Publications: 6.
Study of CE-224,535 A Twice Daily Pill To Control Rheumatoid Arthritis In Patients Who Have Not Totally Improved With Methotrexate
ClinicalTrials.gov study NCT00628095. IPD Sharing: YES. Countries: 7. Publications: 1.
A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis
ClinicalTrials.gov study NCT01232569. IPD Sharing: Not stated. Countries: 22. Publications: 1.
Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550
ClinicalTrials.gov study NCT01059864. IPD Sharing: Not stated. Countries: 2. Publications: 12.
A Study for Patients With Rheumatoid Arthritis on Methotrexate (MTX) With an Inadequate Response to TNFα Inhibitor Therapy
ClinicalTrials.gov study NCT00689728. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Multiple Ascending Doses of Rozibafusp Alfa (AMG 570) in Adults With Rheumatoid Arthritis
ClinicalTrials.gov study NCT03156023. IPD Sharing: YES. Countries: 2. Publications: 1.
Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid Arthritis
ClinicalTrials.gov study NCT02638948. IPD Sharing: Not stated. Countries: 17. Publications: 1.
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