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13
datasets available to search
ShareScore release 0.9.0
Dataset results
13 results for “SCN5A;”
Effect of SCN5A depletion on gene expression in xenograft tumours of MDA-MB-231 breast cancer cells
GEO Series GSE228621. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis of cardiac left-ventricle tissue from hybrid mice harboring the Scn5a-1798insD/+ mutation
GEO Series GSE27236. Mus musculus. 120 samples. Type: Expression profiling by array.
miR-452-5p mediates SCN5A dependent fibrosis via TGF-beta/SMAD4 axis
GEO Series GSE261598. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Maturation of hiPSC-derived cardiomyocytes in tri-cellular cardiac microtissues promotes adult alternative splicing of SCN5A revealing effects of mutations in cardiac disease
GEO Series GSE180290. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A
ClinicalTrials.gov study NCT05274646. IPD Sharing: NO. Countries: 1. Publications: 0.
Genetic background effect on Scn5a mutant cardiac right ventricle gene expression
GEO Series GSE19741. Mus musculus. 12 samples. Type: Expression profiling by array.
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
GEO Series GSE129067. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo (RNA-Seq)
GEO Series GSE123440. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo (Hi-C)
GEO Series GSE129062. Mus musculus. 18 samples. Type: Other.
A rare non-coding enhancer variant in SCN5A contributes to the high prevalence of Brugada syndrome in Thailand
GEO Series GSE264359. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Voltage-gated Sodium Channel SCN5A Promotes Tumor Progression and Enhances Chemosensitivity to 5-Fluorouracil in Colorectal Cancer
GEO Series GSE150134. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
MULTIPLE SCN5A ENHANCERS MODULATE CARDIAC GENE EXPRESSION AND QT INTERVAL VARIATION
GEO Series GSE109716. Homo sapiens; Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Data set from Monasky MM, Micaglio E, Vicedomini G, Locati ET, Ciconte G, Giannelli L, Giordano F, Crisà S, Vecchi M, Borrelli V, Ghiroldi A, D'Imperio S, Di Resta C, Benedetti S, Ferrari M, Santinelli V, Anastasia L, Pappone C. Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants. Europace. 2019 Oct 1;21(10):1550-1558. doi: 10.1093/europace/euz186. PMID: 31292628.
<p>Data set from Monasky MM, Micaglio E, Vicedomini G, Locati ET, Ciconte G, Giannelli L, Giordano F, Crisà S, Vecchi M, Borrelli V, Ghiroldi A, D'Imperio S, Di Resta C, Benedetti S, Ferrari M, Santinelli V, Anastasia L, Pappone C. Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants. Europace. 2019 Oct 1;21(10):1550-1558. doi: 10.1093/europace/euz186. PMID: 31292628.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aims: </strong>The Brugada syndrome (BrS) is an inherited disease associated with an increased risk of sudden cardiac death. Often, the genetic cause remains undetected. Perhaps due at least in part because the NaV1.8 protein is expressed more in both the central and peripheral nervous systems than in the heart, the SCN10A gene is not included in diagnostic arrhythmia/sudden death panels in the vast majority of cardiogenetics centres.</p> <p><strong>Methods and results: </strong>Clinical characteristics were assessed in patients harboring either SCN5A or novel SCN10A variants. Genetic testing was performed using Next Generation Sequencing on genomic DNA. Clinical characteristics, including the arrhythmogenic substrate, in BrS patients harboring novel SCN10A variants and SCN5A variants are comparable. Clinical characteristics, including gender, age, personal history of cardiac arrest/syncope, spontaneous BrS electrocardiogram pattern, family history of sudden death, and arrhythmic substrate are not significantly different between probands harboring SCN10A or SCN5A variants.</p> <p><strong>Conclusion: </strong>Future studies are warranted to further characterize the role of these specific SCN10A variants.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.