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77 results for “SOD1”
Dataset for Superoxide dismutase 1 Cu/Zn (SOD1) antibody screening study
<p><strong>This antibody characterization dataset is related to the F1000 research article openly available at F1000Research.</strong></p> <p><em>This project contains the following underlying data included in a study aiming at characterizing antibodies for the Superoxide dismutase 1 Cu/Zn (SOD1) protein. The original study is also available on the Zenodo YCharOS community (<a href="https://doi.org/10.5281/zenodo.5061103">https://doi.org/10.5281/zenodo.5061103</a>).</em></p>
Dataset related to article "BEHAVIORAL AND COGNITIVE PHENOTYPES OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS CARRYING SOD1 VARIANTS"
<p><strong>ngs_analysis performedn as part of the study mentioned at title</strong></p>
Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT05974579. IPD Sharing: NO. Countries: 1. Publications: 0.
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT00706147. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations
ClinicalTrials.gov study NCT01041222. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Tolerance of RAG-17 in Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation
ClinicalTrials.gov study NCT05903690. IPD Sharing: NO. Countries: 1. Publications: 9.
SOD1 Kinetics Measurements in ALS Patients
ClinicalTrials.gov study NCT03449212. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice
<p>Many Amyotrophic Lateral Sclerosis (ALS) patients experience hypermetabolism, or an increase in measured versus calculated metabolic rate. The cause of hypermetabolism and the effects on neuronal metabolism in ALS are currently unknown, but the efficacy of dietary interventions shows promise for metabolism as an ALS therapeutic target. The goal of this study is to measure changes in metabolic pathways as a function of disease progression in spinal cords of the SOD1G93A mouse model of ALS. We conducted a comprehensive assessment of protein expression for metabolic pathways, antioxidants, chaperones, and proteases in lumbar spinal cord from male SOD1G93A mice at pre-onset, onset, and end-stages of the disease using targeted proteomic analysis. These results reveal that protein content of metabolic proteins including proteins involved in glycolysis, β‐oxidation, and mitochondrial metabolism is altered in SOD1G93A mouse spinal cord well before disease onset. The changes in mitochondrial metabolism proteins are associated with decreased maximal respiration and glycolytic flux in SOD1G93A dermal fibroblasts and increased hydrogen peroxide and lipid hydroperoxide production in mitochondria from sciatic nerve and gastrocnemius muscle fibers at end stage of disease. Consistent with redox dysregulation, expression of the glutathione antioxidant system is decreased, and peroxiredoxins and catalase expression are increased. In addition, stress response proteases and chaperones, including those involved in the mitochondrial unfolded protein response, are induced before disease onset. In summary, we report that metabolic and stress response changes occur in SOD1G93A lumbar spinal cord before motor symptom onset, and are primarily caused by SOD1G93A expression and do not vary greatly as a function of disease course.</p>
NMR Data: Atomic Resolution Map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates
Open the record for dataset details and reuse information.
Multi-Path Direct Current Spinal Stimulation Extended Survival in The SOD1-G93A Model of Amyotrophic Lateral Sclerosis
Open the record for dataset details and reuse information.
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
ClinicalTrials.gov study NCT06351592. IPD Sharing: YES. Countries: 5. Publications: 0.
SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT01083667. IPD Sharing: UNDECIDED. Countries: 4. Publications: 0.
Mouse ES-derived motor neurons (ES-MN) exposed to SOD1 mutant mouse astrocyte conditioned media
GEO Series GSE49023. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative of Transcriptomes in Various Cells Treated with or without LD100 and siRNA of SOD1
GEO Series GSE112007. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNAseq of SOD1 mouse spinal cords
GEO Series GSE287569. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
mRNA sequencing of SOD1 mice identifies differentially expressed genes in disease and after shRNA treatment
GEO Series GSE135539. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
LCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells
GEO Series GSE22482. Mus musculus. 32 samples. Type: Expression profiling by array.
Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice
GEO Series GSE196843. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Early alterations in lipid metabolism in the spinal cord of SOD1 mice
GEO Series GSE184484. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic alteration of SOD1-G93A mutation and leptin deficiency in the adipose tissue
GEO Series GSE248515. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.