Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
333
datasets available to search
ShareScore release 0.9.0
Dataset results
333 results for “Salivary glands”
Full summary statistics of mixQTL for GTEx v8 Minor_Salivary_Gland
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Fig. 6 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 6 Phenotype associated with dynein, kinesin, isocitrate dehydrogenase and citrate synthase mRNA subjected to RNAi in female ticks via injection with the corresponding dsRNA. a Dynein dsRNA injection. b Kinesin dsRNA injection. c Isocitrate dehydrogenase dsRNA injection. d Citrate synthase dsRNA injection. e GFP dsRNA injection, control. f No injection, control. Scale-bars: 5 mm
Fig. 7 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 7 Digital micrographs of salivary gland acinar morphological changes in unfed female H. longicornis after RNAi.The time at which the tick bit the host and began sucking blood was recorded as day 0. a–e Dynein dsRNA injection. f–j Kinesin dsRNA injection. k–o Isocitrate dehydrogenase dsRNA injection. p–t Citrate synthase dsRNA injection. u–y GFP dsRNA injection, control. Scale-bars: 25 µm
Fig. 4 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 4 KEGG pathway enrichment analysis of the differentially expressed proteins in 5 different Clusters. Terms with a P-value <0.05 were used to draw the column diagrams. a–e KEGG pathway enrichment for the proteins in Cluster 1 to Cluster 5
Fig. 3 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 3 GO functional annotations for all the differentially expressed proteins. a–c GO annotations of differentially expressed proteins in the salivary glands of partially fed ticks compared with unfed ticks (115:114). d–f GO annotations of differentially expressed proteins in the salivary glands of mated semi-engorged ticks compared with partially fed ticks (116:115). g–i GO annotations of differentially expressed proteins in the salivary glands of engorged ticks compared with mated semi-engorged ticks (117:116). Abbreviations: BP, biological process; CC, cellular component; MF, molecular function; CO, cellular component organization or biogenesis
Fig. 5 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 5 RT-qPCR analyzed the mRNA expression levels of dynein, kinesin, isocitrate dehydrogenase, and citrate synthase during the four feeding stages of salivary gland development
Fig. 2 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 2 Statistics and cluster analysis for the identified proteins and their expression levels in the salivary glands of female H. longicornis. a Venn diagram showing the number of proteins (with CV <20%) identified in the three experiments. b Venn diagram showing the number of proteins with quantitative information. c Cluster analysis according to trends in protein expression in the salivary glands of female ticks
Fig. 1 in Salivary gland proteome analysis of developing adult female HaemaphYSaliS longiCorniS ticks: molecular motor and TCA cycle-related proteins play an important role throughout development
Fig. 1 Workflow for quantitative proteomics analysis of changes in protein expression in the salivary glands of female H. longicornis during the blood-feeding process
Figures 1-4 in Ultrastructural detection of lipids in the cephalic salivary glands of Apis mellifera and Scaptotrigona postica (Hymenoptera: Apidae) workers
Figures 1-4. Lipids, detected using imidazole-osmium, in cephalic salivary gland (CSG) cells of Apis mellifera workers. (1-2) Small droplets of lipid (arrows) dispersed in the cellular cytoplasm of a newly emerged worker (NE), mitochondria (m) of medium electron density and narrow alveolar lumens (l) containing scarce IO-positive secretion (s). (3-4) Gland cells from workers working in the brood comb area (CA). Note lipid droplets dispersed in the cytoplasm (arrows) (1C), heterogeneous granules (gr) (1D) and large amounts of lipid secretion (s) in the alveolar lumen (l). (c) Cuticle, (n) nuclei. Scale bars: 1, 2, 4 = 1 µm, 3 = 3 µm.
Figures 5-8 in Ultrastructural detection of lipids in the cephalic salivary glands of Apis mellifera and Scaptotrigona postica (Hymenoptera: Apidae) workers
Figures 5-8. Imidazole-osmium preparations for lipid detection in gland cells from Apis mellifera workers. (5-6) Gland cells from worker working in the brood comb area (CA) (5) and forager (FO) (6) showing lipid droplets dispersed in the apical region (arrow), infolds (i) of the apical membrane forming channels flanked by mitochondria (m). (6) Note the presence of lipid droplets in the apical channels (arrows). (7-8) Osmium-imidazole-positive dots spread in the cytoplasm (arrows) and vesicles (ve) of forager cellular glands. (c) Cuticle, (s) secretion. Scale bars: 5 = 3 µm, 6 = 2 µm, 7-8 = 1 µm.
Figs 37-54 in Mg -dependent ATPase activity in triatomine salivary glands (Heteroptera, Triatominae)
Figs 37-54, Salivary glands of male T. infestans (Figs 37-45) and P. megistus (Figs 46-54) submitted to the control method (absence of substrate) of cytochemical for Mg2 +-dependent ATPase. General view and detail of anterior (Figs 37-39; 46-48), median (Figs 40-42; 49-51), and posterior (Figs 43- 45; 52-54) salivary gland. Note the absence of enzyme activity in the nucleus (Nu) and cytoplasm. Magnifications: Figs 37, 40, 43, 46, 49, 52 = 270x; Figs 38, 39, 41, 42, 44, 45, 47, 48, 50, 51, 53, 54 = 1344x.
Figs 19-36 in Mg -dependent ATPase activity in triatomine salivary glands (Heteroptera, Triatominae)
Figs 19-36. Panstrongylus megistus (Burmeister, 1835), salivary glands of males (Figs 19-27) and females (Figs 28-36) submitted to cytochemical reaction for Mg2 +-dependent ATPase. General view and detail of anterior (Figs 19-21, 28-30), median (Figs 22-24, 31-33), and posterior (Figs 25-27, 34-36) salivary gland. Arrows indicate dark nuclear corpuscles with a strong cobalt sulfide precipitation. The arrowheads indicate a positive response in the nuclear envelope. Magnifications: Figs 19, 22, 25, 28, 31, 34 = 270x; Figs 20, 21, 23, 24, 26, 27, 29, 30, 32, 33, 35, 36 = 1344x.
Figs 1-18 in Mg -dependent ATPase activity in triatomine salivary glands (Heteroptera, Triatominae)
Figs 1-18. Triatoma infestans (Klug, 1834), salivary glands of males (Figs 1-9) and females (Figs 10-18) submitted to cytochemical reaction for Mg2 +-dependent ATPase. General view and detail of anterior (Figs 1-3, 10-12), median (Figs 4-6, 13-15), and posterior (Figs 7-9, 16-18) salivary gland. Arrows indicate dark nuclear corpuscles with a strong cobalt sulfide precipitation. The arrowheads indicate a positive response in the nuclear envelope. Magnifications: Figs 1, 4, 7, 10, 13, 16 = 270x; Figs 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18 = 1344x.
scRNA-seq of CD45+ cells from salivary gland of Aire-knockout rats
Open the record for dataset details and reuse information.
Single-cell RNA sequencing of human salivary gland derived mesenchymal stromal cells under cytokine treatment conditions
Open the record for dataset details and reuse information.
Bulk RNA sequencing of human mesenchymal stromal cells derived from labial salivary glands, bone marrow, and adipose
Open the record for dataset details and reuse information.
Dataset related to article "NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation."
<p>Salivary glands (SGs) represent a permissive site for several sialotropic viruses whose persistence is linked to the development of autoimmunity. Natural Killer (NK) cells play a key role in viral clearance but their involvement in viral infection control and in tertiary lymphoid structures (TLS) development within SGs is unknown. By using an inducible model of TLS in the SGs of wild-type C57BL/6 mice, induced by the local delivery of a replication-defective adenovirus (AdV), we demonstrated that circulating NK cells are rapidly recruited to SGs and highly enrich the early inflammatory infiltrate prior to TLS development. NK cells migrating to SGs in response to AdV infection up-regulate NKp46, undergo proliferation, acquire cytotoxic potential, produce Granzyme-B and IFN-γ, and reduce viral load in the acute phase of the infection. Nonetheless, the selective depletion of both circulating and infiltrating NK cells in AdV-infected mice neither affect the development and frequency of TLS nor the onset of autoimmunity. These data demonstrate that, upon local viral delivery of AdV, peripheral NK cells homing to SGs can exert an early control of the viral infection but are dispensable for the formation of TLS and breach of immunologic tolerance.</p> <p> </p> <p>This research used pzf and ets file form extensions, we attach pdfs information about</p>
Data for PNASnexus article Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
<p>Adult salivary stem/progenitor cells (SSPC) have an intrinsic property to self-renew in order to maintain tissue architecture and homeostasis. Adult salivary glands have been documented to harbor SSPC, which have been shown to play a vital role in the regeneration of the glandular structures post radiation damage. We have previously demonstrated that activation of aldehyde dehydrogenase 3A1 (ALDH3A1) after radiation reduced aldehyde accumulation in SSPC, leading to less apoptosis and improved salivary function. We subsequently found that sustained pharmacological ALDH3A1 activation is critical to enhance regeneration of murine submandibular gland after radiation damage. Further investigation shows that ALDH3A1 function is crucial for SSPC self-renewal and survival even in the absence of radiation stress. Salivary glands from <em>Aldh3a1</em>-null mice have fewer acinar structures than wildtype mice. ALDH3A1 deletion or pharmacological inhibition in SSPC leads to a decrease in mitochondrial DNA copy number, lower expression of mitochondrial specific genes and proteins, structural abnormalities, lower membrane potential, and reduced cellular respiration. Loss or inhibition of ALDH3A1 also elevates ROS levels and accumulation of ALDH3A1 substrate 4-hydroxynonenal (4-HNE, a lipid peroxidation product), leading to decreased survival of murine SSPC that can be rescued by treatment with 4-HNE specific carbonyl scavengers. Our data indicate that ALDH3A1 activity protects mitochondrial function and is important for the regeneration activity of SSPC. This knowledge will help to guide our translational strategy of applying ALDH3A1 activators in the clinic to prevent radiation-related hyposalivation in head and neck cancer patients.</p>
RNAseq of salivary gland IL10 positive CD4+ Tcells versus IL10 negative CD4+ Tcells at day14 post MCMV infection
<p>Bulk RNAseq, DESeq2 (https://bioconductor.org/packages/release/bioc/html/DESeq2.html) output for salivary gland IL10 positive CD4+ Tcells versus IL10 negative CD4+ Tcells at day14 post MCMV infection.</p>
Microbubbles in human salivary glands
<p>Supplementary video: a video captured from the ultrasound machine, illustrating the variable penetration patterns of microbubbles into glandular tissue. Videos of (A) left parotid gland with complete homogeneous dense penetration of microbubbles. (B) Right submandibular gland (SMG) with complete, inhomogeneous dense penetration of microbubbles. (C) Right parotid gland with complete homogenous penetration of microbubbles with moderate density. (D) Left SMG with no penetration of microbubbles. Only the main duct is visible.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.