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13 results for “Schistosoma mansoni parasite”
Resource fluctuations inhibit the reproduction and virulence of the human parasite Schistosoma mansoni in its snail intermediate host
Resource availability can powerfully influence host-parasite interactions. However, we currently lack a mechanistic framework to predict how resource fluctuations alter individual infection dynamics. We address this gap with experiments manipulating resource supply and starvation for a human parasite, Schistosoma mansoni, and its snail intermediate host to test a hypothesis derived from mechanistic energy budget theory: resource fluctuations should reduce schistosome reproduction and virulence by inhibiting parasite ingestion of host biomass. Low resource supply caused hosts to remain small, reproduce less, and produce fewer human-infectious cercariae. Periodic starvation also inhibited cercarial production and prevented infection-induced castration. The periodic starvation experiment also revealed substantial differences in fit between two bioenergetic model variants, which differ in their representation of host starvation. Simulations using the best fit parameters of the winning model suggest that schistosome performance substantially declines with resource fluctuations with periods >7 days. These experiments strengthen mechanistic theory that can be readily scaled up to the population level to understand key feedbacks between resources, host population dynamics, parasitism, and control interventions. Integrating resources with other environmental drivers of disease in an explicit bioenergetic framework could ultimately yield mechanistic predictions for many disease systems.
Time series analysis of tegument ultrastructure of in vitro transformed miracidium to mother sporocyst of the human parasite Schistosoma mansoni
<p>Here is a compilation of all the Scanning Electron Microscopy pictures at our disposal regarding the in vitro transformation of miracidia to mother sporocysts of <em>Schistosoma mansoni</em>. These datas were partially published in:</p> <p><a href="https://doi.org/10.1016/j.actatropica.2023.106840">https://doi.org/10.1016/j.actatropica.2023.106840</a></p> <p> </p>
Resource fluctuations inhibit the reproduction and virulence of the human parasite Schistosoma mansoni in its snail intermediate host
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Data from: Inbreeding within human Schistosoma mansoni: do host- specific factors shape the genetic composition of parasite populations?
The size, structure and distribution of host populations are key determinants of the genetic composition of parasite populations. Despite the evolutionary and epidemiological merits, there has been little consideration of how host heterogeneities affect the evolutionary trajectories of parasite populations. We assessed the genetic composition of natural populations of the parasite Schistosoma mansoni in northern Senegal. A total of 1346 parasites were collected from 14 snail and 57 human hosts within three villages and individually genotyped using nine microsatellite markers. Human host demographic parameters (age, gender and village of residence) and co-infection with Schistosoma haematobium were documented, and S. mansoni infection intensities were quantified. F-statistics and clustering analyses revealed a random distribution (panmixia) of parasite genetic variation among villages and hosts, confirming the concept of human hosts as 'genetic mixing bowls' for schistosomes. Host gender and village of residence did not show any association with parasite genetics. Host age, however, was significantly correlated with parasite inbreeding and heterozygosity, with children being more infected by related parasites than adults. The patterns may be explained by (1) genotype-dependent 'concomitant immunity' that leads to selective recruitment of genetically unrelated worms with host age, and/or (2) the 'genetic mixing bowl' hypothesis, where older hosts have been exposed to a wider variety of parasite strains than children. The present study suggests that host-specific factors may shape the genetic composition of schistosome populations, revealing important insights into host–parasite interactions within a natural system.
Data from: Inbreeding within human Schistosoma mansoni: do host- specific factors shape the genetic composition of parasite populations?
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Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
<p><span><span><span><span><span><span><span><span><span><span><span>Schistosomes kill 250,000 people every year. Treatment of schistosomiasis relies on a single drug (praziquantel). Unfortunately, a scarcity of molecular tools has hindered the discovery of new drug targets. Here, we describe a large-scale RNA interference screen in adult Schistosoma mansoni examining the function of 2,216 genes. We discovered 250 genes with phenotypes affecting neuromuscular function, tissue integrity, stem cell maintenance, and parasite survival. Leveraging these data, we prioritize compounds with activity against the parasites and uncover a pair of protein kinases (TAO and STK25) that cooperate to maintain muscle-specific mRNA transcription. Loss of either of these kinases results in paralysis and worm death in a mammalian host. These studies will expedite therapeutic development and invigorate studies of these neglected parasites. Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni.</span></span></span></span></span></span></span></span></span></span></span></p> <p> </p>
Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
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Single-cell analysis reveals regulation of germline stem cell fate in the human parasite Schistosoma mansoni
GEO Series GSE147355. Schistosoma mansoni. 29 samples. Type: Expression profiling by high throughput sequencing.
Adult stem cells in the human parasite Schistosoma mansoni
GEO Series GSE42757. Schistosoma mansoni. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Profiling of Schistosoma mansoni f zfp-1-1(RNAi) parasites
GEO Series GSE106693. Schistosoma mansoni. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of Praziquantel on the Differential Expression of Mouse Hepatic Genes and Parasite ATP Binding Cassette Transporter Gene Family Members During Schistosoma mansoni Infection
GEO Series GSE94132. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
GEO Series GSE146720. Schistosoma mansoni. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of Schistosoma mansoni male parasites after culturing with female parasites for 72 hours
GEO Series GSE290988. Schistosoma mansoni. 3 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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