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96 results for “Schizosaccharomyces pombe”
Data for integrative modeling of the Nuclear Pore Complex from Schizosaccharomyces pombe
<p>Repository with input and output files utilized for integrative modeling of the Nuclear Pore Complex from Schizosaccharomyces pombe.</p>
Competition dynamics in long-term propagations of Schizosaccharomyces pombe strain communities
<p>Experimental evolution studies with microorganisms such as bacteria and yeast have been an increasingly important and powerful tool to draw long-term inferences of how microbes interact. However, while several strains of the same species often exist in natural environments, many ecology and evolution studies in microbes are typically performed with isogenic populations of bacteria or yeast. In the present study, we firstly perform a genotypic and phenotypic characterization of two lab and eight natural strains of the yeast <i>Schizosaccharomyces pombe</i>. We then propagated, in a rich resource environment, yeast communities of 2-, 3-, 4- and 5-strains for hundreds of generations and asked which fitness related phenotypes – maximum growth rate or relative competitive fitness – would better predict the outcome of a focal strain during the propagations. While the strain's growth rates would wrongly predict long-term co-existence, pairwise competitive fitness with a focal strain qualitatively predicted the success or extinction of the focal strain by a simple multi-genotype population genetics model, given the initial community composition. Interestingly, we have also measured the competitive fitness of the ancestral and evolved communities by the end of the experiment (≈370 generations) and observed frequent maladaptation to the abiotic environment in communities with more than three members. Overall, our results aid establishing pairwise competitive fitness as good qualitative measurement of long-term community composition but also reveal a complex adaptive scenario when trying to predict the evolutionary outcome of those communities.</p>
Competition dynamics in long-term propagations of Schizosaccharomyces pombe strain communities
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Data from: Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe
Replicative aging has been demonstrated in asymmetrically dividing unicellular organisms, seemingly caused by unequal damage partitioning. Although asymmetric segregation and inheritance of potential aging factors also occurs in symmetrically dividing species, it nevertheless remains controversial whether this results in aging. Based on large-scale single-cell lineage data obtained by time-lapse microscopy with a microfluidic device, in this report, we demonstrate the absence of replicative aging in old-pole cell lineages of Schizosaccharomyces pombe cultured under constant favorable conditions. By monitoring more than 1,500 cell lineages in seven different culture conditions, we showed that both cell division and death rates are remarkably constant for at least 50–80 generations. Our measurements revealed that the death rate per cellular generation increases with division rate, pointing to a physiological trade-off with fast growth under balanced growth conditions. We also observed the formation and inheritance of Hsp104-associated protein aggregates, which are a potential aging factor in old-pole cell lineages, and found that these aggregates exhibited a tendency to preferentially remain at the old-poles for several generations. However, the aggregates were eventually segregated from old-pole cells upon cell division and probabilistically allocated to new-pole cells. We found that cell deaths were typically preceded by sudden acceleration of protein aggregation, thus relatively large amount of protein aggregates existed at the very ends of the dead cell lineages. Our lineage tracking analyses, however, revealed that the quantity and inheritance of protein aggregates increased neither cellular generation time nor cell death initiation rates. Furthermore, our results demonstrated that unusually large amounts of protein aggregates induced by oxidative stress exposure did not result in aging; old-pole cells resumed normal growth upon stress removal, despite the fact that most of them inherited significant quantities of aggregates. These results collectively indicate that protein aggregates are not a major determinant of triggering cell death in S. pombe, and thus cannot be an appropriate molecular marker or index for replicative aging under both favorable and stressful environmental conditions.
Data from: Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe
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Expression profiling and ChIP-chip of Schizosaccharomyces pombe strains wildtype, erh1∆, and ccr4∆
GEO Series GSE76114. Schizosaccharomyces pombe. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by genome tiling array.
Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and ppr10 deletion Schizosaccharomyces pombe cell Transcriptomes
GEO Series GSE90144. Schizosaccharomyces pombe. 2 samples. Type: Expression profiling by high throughput sequencing.
ChIP-on-chip of RPA (Ssb1) in cdc25-22 and cdc25-22 rad3∆ in Schizosaccharomyces pombe
GEO Series GSE107097. Schizosaccharomyces pombe. 6 samples. Type: Other.
The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
GEO Series GSE59178. Schizosaccharomyces pombe. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Structural and functional characterization of the N-terminus of Schizosaccharomyces pombe Cwf10
GEO Series GSE47573. Schizosaccharomyces pombe. 8 samples. Type: Expression profiling by high throughput sequencing.
RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe
GEO Series GSE54195. Schizosaccharomyces pombe; Schizosaccharomyces pombe 972h-. 10 samples. Type: Expression profiling by genome tiling array; Non-coding RNA profiling by high throughput sequencing.
Heterochromatin state in fission yeast Schizosaccharomyces pombe
GEO Series GSE42850. Schizosaccharomyces pombe. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Genome-wide data of RNAs associated to Mmi1 in wild type Schizosaccharomyces pombe cells
GEO Series GSE90688. Schizosaccharomyces pombe. 4 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
The fission yeast Schizosaccharomyces pombe: H3K9me2, Erh1-GFP and CFP-Mmi1 ChIP-chip
GEO Series GSE76111. Schizosaccharomyces pombe. 16 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Disrupted lipid homeostasis in the absence of the transcriptional activator mga2 results in a failure to activate SREBPs in Schizosaccharomyces pombe
GEO Series GSE60544. Schizosaccharomyces pombe. 2 samples. Type: Expression profiling by array.
RNA sequencing of Schizosaccharomyces pombe cells with the replaced fatty acid synthase complex from Schizosaccharomyces japonicus
GEO Series GSE141579. Schizosaccharomyces pombe. 4 samples. Type: Expression profiling by high throughput sequencing.
Small RNA expression in swi6 mutants or dcr1 delta fission yeast Schizosaccharomyces pombe
GEO Series GSE42849. Schizosaccharomyces pombe. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The fission yeast Schizosaccharomyces pombe: H3K9me2 and Fep1-GFP ChIP-chip
GEO Series GSE104528. Schizosaccharomyces pombe. 9 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Genome-wide mapping of histone H2A phosphorylation during S-phase in Schizosaccharomyces pombe (fission yeast)
GEO Series GSE23758. Schizosaccharomyces pombe. 2 samples. Type: Genome binding/occupancy profiling by genome tiling array.
RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe [Illumina Genome Analyzer]
GEO Series GSE54194. Schizosaccharomyces pombe 972h-. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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