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8 results for “Self-amplifying RNA”
Design-of-Experiments In Vitro Transcription Yield Optimization of Self-Amplifying RNA
<p>This dataset contains original data generated from optimizing the IVT process for saRNAs that are approximately 9 kb in size through a design of experiment (DoE) approach to produce a maximal RNA yield.</p>
Data from: Self-amplifying RNA generated with the modified nucleotides 5-methylcytidine and 5-methyluridine mediate strong expression and immunogenicity in vivo
<p>When utilized in therapeutic applications, synthetic self-amplifying RNA can lead to higher and more sustained expression than standard messenger RNA. This feature is particularly important for gene replacement therapy applications where prolonged expression could reduce the dose and frequency of treatments. The inclusion of modified nucleotides in synthetic non-amplifying mRNA has been shown to increase RNA stability, reduce immune activation and enhance gene expression. Preclinical and clinical studies with self-amplifying RNA (saRNA) have so far exclusively relied on RNA containing the canonical nucleotides adenosine, cytidine, guanosine and uridine. For the first time, we show that non-canonical nucleotides, such as m5C and m5U, are sufficiently compatible with a replicon derived from Venezuelan equine encephalitis alphavirus mediating protein translation <em>in vitro</em>, while those containing m1ψ in place of uridine show no detectable expression. When administered <em>in vivo</em>, saRNA generated with m5C or m5U mediate sustained gene expression of the luciferase reporter gene with those incorporating m5U appearing to lead to more prolonged expression. Finally, distinct antigen-specific humoral and cellular immune responses were induced by modified saRNA encoding the model antigen ovalbumin. The use of modified nucleotides with saRNA-based platforms could enhance their potential to be used effectively in a variety of applications.</p>
Data from: Self-amplifying RNA generated with the modified nucleotides 5-methylcytidine and 5-methyluridine mediate strong expression and immunogenicity in vivo
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The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)
ClinicalTrials.gov study NCT05012943. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
ClinicalTrials.gov study NCT06799013. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Immunogenicity First-in-human Dose-ranging Study of Self-Amplifying RNA Seasonal Influenza Vaccine in Adults
ClinicalTrials.gov study NCT06125691. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Immunogenicity Study of Self-Amplifying RNA Pandemic Influenza Vaccine in Adults
ClinicalTrials.gov study NCT06602531. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study To Learn About The Study Vaccine (Called Self-Amplifying Ribonucleic Acid (RNA)) For The Prevention of Influenza
ClinicalTrials.gov study NCT05227001. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.