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9 results for “Sepsis-3”
Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – a prospective population-based study.
<p>Sepsis epidemiology study 2011-2012 Sweden</p> <p>Ljungström, Lars; Andersson, Rune; Jacobsson, Gunnar</p> <p> </p> <p>Data collected during the prospective "Sepsis Skaraborg study" performed 2011-2012 in the western region of Sweden. Adult patients admitted to the emergency department for suspicion of a community-onset sepsis were evaluated. The study was approved by the Regional Ethical Review Board of Gothenburg (376-11). The file includes data for patient characteristics, vital signs, biomarker measurements, cases of bacteremia, and patient classifications using Sepsis-2 and Sepsis-3 criteria.</p>
Validation of Sepsis-3 using survival analysis and clinical evaluation of quick SOFA, SIRS, and burn-specific SIRS for sepsis in burn patients with suspected infection
<p><span><strong>Purpose</strong>: Sepsis-3 is a life-threatening organ dysfunction caused by dysregulated host responses to infection; and defined using the Sepsis-3 criteria, introduced in 2016, however, the criteria need to be validated in specific clinical fields. We investigated mortality prediction and compared the diagnostic performance of quick Sequential Organ Failure Assessment (qSOFA), systemic inflammatory response syndrome (SIRS), and burn-specific SIRS (bSIRS) in burn patients.</span></p> <p><span><strong>Methods</strong>: This single-center retrospective cohort study examined burn patients in Seoul, Korea during January 2010–December 2020. Overall, 1,391 patients with suspected infection were divided into four sepsis groups using SOFA, qSOFA, SIRS, and burn-specific SIRS. </span></p> <p><span><strong>Results</strong>: Hazard ratios (HRs) of all unadjusted models were statistically significant; however, the HR (0.726, p = 0.0080.001) in the SIRS ≥2 group is below 1. In the adjusted model, HRs of the SOFA ≥2 (2.426, p < 0.001), qSOFA ≥2 (7.198, p < 0.001), and SIRS ≥2 (0.575, p < 0.001) groups were significant. The diagnostic performance of dichotomized qSOFA, SIRS, and bSIRS for sepsis was defined by the Sepsis-3 criteria. The mean onset day was 4.13±2.97 according to Sepsis-3. The sensitivity of SIRS (0.989, 95% confidence interval [CI]: 0.982–0.994) was higher than that of qSOFA (0.841, 95% CI: 0.819–0.861) and bSIRS (0.803, 95% CI: 0.779–0.825). Specificities of qSOFA (0.929, 95% CI: 0.876–0.964) and bSIRS (0.922, 95% CI: 0.868–0.959) were higher than those of SIRS (0.461, 95% CI: 0.381–0.543).</span></p> <p><span><strong>Conclusion</strong>: Sepsis-3 is a good alternative diagnostic tool because it reflects sepsis severity without delaying diagnosis. SIRS showed higher sensitivity than qSOFA and bSIRS and may therefore more adequately diagnose sepsis.</span></p>
Validation of Sepsis-3 using survival analysis and clinical evaluation of quick SOFA, SIRS, and burn-specific SIRS for sepsis in burn patients with suspected infection
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Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey
ClinicalTrials.gov study NCT07300306. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
ClinicalTrials.gov study NCT02180009. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Relevance of IL-3 for lung transcriptomic response in murine sepsis followed by HSV infection
GEO Series GSE224299. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Sepsis-3 Study in Northeast Thailand
ClinicalTrials.gov study NCT03379402. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Expression of TIM-3 on Lymphocytes in Sepsis
ClinicalTrials.gov study NCT02319876. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Plasma extracellular vesicle miR-483-3p and let-7d-3p as potential biomarkers for sepsis
GEO Series GSE184803. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by array.
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