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130
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Dataset results
130 results for “Shigella”
The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant Shigella spp.
<p><strong>dataset for The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant <em>Shigella</em> spp.</strong></p> <p>Elena Fernández Alvaro <sup>1*</sup>, Phat Voong Vinh <sup>2</sup>, Cristina de Cozar <sup>1</sup>, David Wille <sup>1</sup>, Beatriz Urones <sup>1</sup>,</p> <p>Alan Price <sup>1</sup>, Nhu Tran Do Hoang <sup>2</sup>, Tuyen Ha Thanh <sup>2</sup>, Molly McCloskey <sup>3</sup>, Shareef Shaheen<sup> 3</sup>, Denise Dayao<sup> 4</sup>, Jaime de Mercado <sup>1</sup>, Pablo Castañeda <sup>1</sup>, Adolfo García-Perez <sup>1</sup>, Benson Singa <sup>5</sup>, Patricia Pavlinac <sup>6</sup>,</p> <p>Judd Walson<sup>3</sup>, Maria Santos Martínez-Martínez <sup>1</sup>, Samuel L.M. Arnold <sup>3</sup>, Tzipori Saul <sup>4</sup>, Lluis Ballell <sup>1#</sup>,</p> <p>and Stephen Baker <sup>7,8*</sup></p> <p> </p>
High-content high-resolution microscopy and deep learning assisted analysis reveals host and bacterial heterogeneity during Shigella infection
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MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47
<p>Enzyme kinetics data from "MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47".</p>
Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors
<p>Spa47 inhibition data from "Shutting Down <em>Shigella</em> Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors".</p>
Shigella Congo red secretion profile unaltered Western blots
<p>These are unaltered raw Western blot images (Image Lab files) of a Congo red secretion assay testing the type three secretion profiles of <em>Shigella</em> strains expressing engineered Spa47 mutants.</p>
Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in Israel
ClinicalTrials.gov study NCT00368316. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Phase 2 Shigella Vaccine and Challenge
ClinicalTrials.gov study NCT04242264. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR)
ClinicalTrials.gov study NCT02445963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults
ClinicalTrials.gov study NCT01509846. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine Candidate
ClinicalTrials.gov study NCT01080716. IPD Sharing: YES. Countries: 1. Publications: 1.
Dose-Finding Study of Lyophilized Shigella Sonnei 53G Challenge Strain
ClinicalTrials.gov study NCT02816346. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety Study of Live Attenuated Oral Shigella (WRSS1) Vaccine in Bangladeshi Adults and Children
ClinicalTrials.gov study NCT01813071. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.
ClinicalTrials.gov study NCT02017899. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Supplementary material from: Burden of Shigella among children with diarrhea in the Americas: A systematic review and meta-analysis
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A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella
Dissemination of antimicrobial resistance (AMR) genes by horizontal gene transfer (HGT) mediated through plasmids is a major global concern. Genomic epidemiology studies have shown varying success of different AMR plasmids during outbreaks, but the underlying reasons for these differences are unclear. Here, we investigated two Shigella plasmids (pKSR100 and pAPR100) that circulated in the same transmission network but had starkly contrasting epidemiological outcomes to identify plasmid features that may have contributed to the differences. We used plasmid comparative genomics to reveal divergence between the two plasmids in genes encoding AMR, SOS response alleviation, and conjugation. Experimental analyses revealed that these genomic differences corresponded with reduced conjugation efficiencies for the epidemiologically successful pKSR100, but more extensive AMR, reduced fitness costs, and a reduced SOS response in the presence of antimicrobials, compared with the less successful pAPR100. The discrepant phenotypes between the two plasmids are consistent with the hypothesis that plasmid associated phenotypes contribute to determining the epidemiological outcome of AMR HGT and suggest that phenotypes relevant in responding to antimicrobial pressure and fitness impact may be more important than those around conjugation in this setting. Plasmid phenotypes could thus be valuable tools in conjunction with genomic epidemiology for predicting AMR dissemination.
FIGURE 381 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURE 381. Majority rule consensus tree produced from analysis of combined 28S D2 sequence data and morphological data for the Geometridae (16 MPT's, length = 2064, 10,000 replicates, CI = 0.24, RI = 0.45, RCI = 0.11). Numbers above branches are bootstrap percentages> 50% (10, 000 replicates). A = Archiearinae, Al = Alsophilinae, Az = Azelinini, B = Boarmiini, C = Caberini, D = Drepanidae, E = Ennomini, G = Geometrinae, L = Lithinini, M = Macariini, N = Nacophorini, No = Noctuidae, O = Oenochrominae, S = Sterrhinae.
FIGURE 379 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURE 379. Maximum parsimony strict consensus tree (27 MPT's, length =786, CI = 0.18, RI = 0.50, RCI = 0.09) constructed from morphological characters for the Geometridae (see Fig. 240). Numbers are bootstrap percentages> 50. A—Archiearinae, Al—Alsophilinae, Az—Azelinini, B—Boarmiini, C—Caberini, D—Drepanidae, E—Ennomini, G— Geometrinae, La—Larentiinae, L—Lithinini, M—Macariini, N—Nacophorini, No—Noctuidae, O—Oenochrominae, S —Sterrhinae.
FIGURE 380 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURE 380. Maximum parsimony majority rules consensus tree (27 MPT's, length =786, CI = 0.18, RI = 0.50, RCI = 0.09) constructed from morphological characters for the Geometridae (see Fig. 240). Numbers are percentage of trees in which clade occurs. A = Archiearinae, Al = Alsophilinae, Az = Azelinini, B = Boarmiini, C = Caberini, D = Drepanidae, E = Ennomini, G = Geometrinae, L = Larentiinae, Li = Lithinini, M = Macariini, N = Nacophorini, No = Noctuidae, O = Oenochrominae, S = Sterrhinae
FIGURES 371–377. Female genitalia. 372. Chlorocoma vertumnaria, 373 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 371–377. Female genitalia. 372. Chlorocoma vertumnaria, 373. Heliomystis electrica, arrows indicate pheromone glands, 374. Hypobapta percomptaria, 375. Sterictopsis sp., 376. Hoplosauris perornata, 377. Scopula perlata,
FIGURES 363–370 in Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
FIGURES 363–370. Female genitalia of Geometridae. 363. Nearcha curtaria, 364. Acalyphes philorites, 365. Acalyphes sp., 366. Archiearides fidonioides, 367. Dirce aesiodora, 368. Dirce lunaris, 369. Dirce sp, 370. Dirce oriplancta, 371. Dirce solaris.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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