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129 results for “Skeletal muscle function”
Effect of burosumab on muscle function and strength, and rates of ATP synthesis in skeletal muscle in adults with X-linked Hypophosphatemia
<p><strong>Abstract</strong></p> <p><strong>Context: </strong>Burosumab, a neutralizing antibody to FGF23, is approved for the treatment of X-linked hypophosphatemia. In clinical trials burosumab improves symptoms of pain, fatigue and stiffness and improves performance on certain muscle function studies.</p> <p><strong>Objective: </strong>Determine if burosumab would increase ATP synthesis in skeletal muscle of treatment-naïve adults with XLH and if so whether that correlated with improved muscle function.</p> <p><strong>Methods: </strong>Ten symptomatic adults, who had not received any treatment for XLH for years, had ATP synthesis rates assessed in the soleus/gastrocnemius muscle complex of the right calf using the <sup>31</sup>P magnetic resonance spectroscopy saturation transfer technique. Baseline muscle function tests and symptoms of pain, fatigue, stiffness and lower extremity joint pain were quantified. All participants were treated with burosumab, 1 mg/kg every four weeks for 12 weeks. ATP synthesis rates and muscle function tests were repeated 2-weeks (“peak”) and 4-weeks (“trough”) after the third dose of burosumab.</p> <p><strong>Results: </strong>Pain, fatigue, stiffness and lower extremity joint pain all improved with treatment. Performance on the 6-Minute Walk and Sit to Stand tests also improved significantly. Performance on the Timed Up and Go test did not significantly improve (p = 0.057). Muscle strength, measured by dynamometry, did not change significantly in either the upper or lower extremities during the study. ATP synthesis rates did not change over the three months of study in the group as whole. In a sub-analysis comparing individuals whose performances on the 6-Minute Walk Test and Sit to Stand tests were at or better than the mean outcome for those tests, to those whose outcomes were below the mean, no difference was observed in the rate of change in ATP synthesis rates. Despite profound and prolonged hypophosphatemia at baseline, intracellular muscle concentrations of phosphorus were normal.</p> <p><strong>Conclusion: </strong>The improvement in the 6-Minute Walk Test and Sit to Stand tests without any observed change in either upper or lower extremity muscle strength or ATP synthesis rates, suggests that improvement in pain, fatigue and stiffness may explain, at least in part, the improved performance on these two tests. The preserved intracellular phosphate levels suggests that adaptive mechanisms are present in skeletal muscle that insulate intracellular phosphorus from life-long FGF23-mediaed hypophosphatemia.</p>
Data from: Passive skeletal muscle can function as an osmotic engine
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Up-regulation of sarcoplasmic reticulum function protects skeletal muscle against cytoplasmic calcium overload during hibernation in ground squirrels
<p>We investigated the potential mechanism of the SR in maintenance of calcium (Ca<sup>2+</sup>) homeostasis of slow-twitch muscle (soleus, SOL), fast-twitch muscle (extensor digitorum longus, EDL) and mixed muscle (gastrocnemius, GAS) in hibernating ground squirrels (<i>Spermophilus dauricus</i>). Results showed that cytosolic and SR Ca<sup>2+</sup> concentrations in distinct skeletal muscle fibers increased and decreased during late torpor, respectively, but both returned to summer-active levels during early torpor. Ryanodine receptor1 (RyR1) and sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase isoform 1 (SERCA1) protein expression increased during hibernation. Up-regulation factors of SERCA activity: Phospholamban phosphorylation increased in the SOL and GAS, β-adrenergic receptor-2 protein expression increased in the GAS, and calmodulin kinase-2 phosphorylation increased in the SOL during hibernation. Down-regulation factors of SERCA activity: Sarcolipin and SERCA1 co-localization decreased in the EDL and GAS. These data suggest that SERCA activity in skeletal muscle fibers increases likely during hibernation. FKBP12/calsequestrin1 (negative regulatory factors of RyR1) and RyR1 co-localization decreased in the GAS, indicating that the RyR1 channel opening probability increased during hibernation. Dihydropyridine receptors protein expression and its co-localization with RYR1 decreased during hibernation prompts that the contractility of skeletal muscle was weakened. Protein expression of Ca<sup>2+</sup>-binding proteins calsequestrin1 and calmodulin increased indicating that the ability of intracellular free calcium binding increased during whole hibernation period. These findings confirm that the release, uptake, and binding of free Ca<sup>2+</sup> in the SR were enhanced in different skeletal muscles during hibernation. Up-regulation of muscular sarcoplasmic reticulum function protects skeletal muscle fibers against cytoplasmic calcium overload during hibernation in ground squirrels.We investigated the potential mechanism of the SR in maintenance of calcium (Ca<sup>2+</sup>) homeostasis of slow-twitch muscle (soleus, SOL), fast-twitch muscle (extensor digitorum longus, EDL) and mixed muscle (gastrocnemius, GAS) in hibernating ground squirrels (<i>Spermophilus dauricus</i>). Results showed that cytosolic and SR Ca<sup>2+</sup> concentrations in distinct skeletal muscle fibers increased and decreased during late torpor, respectively, but both returned to summer-active levels during early torpor. Ryanodine receptor1 (RyR1) and sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase isoform 1 (SERCA1) protein expression increased during hibernation. Up-regulation factors of SERCA activity: Phospholamban phosphorylation increased in the SOL and GAS, β-adrenergic receptor-2 protein expression increased in the GAS, and calmodulin kinase-2 phosphorylation increased in the SOL during hibernation. Down-regulation factors of SERCA activity: Sarcolipin and SERCA1 co-localization decreased in the EDL and GAS. These data suggest that SERCA activity in skeletal muscle fibers increases likely during hibernation. FKBP12/calsequestrin1 (negative regulatory factors of RyR1) and RyR1 co-localization decreased in the GAS, indicating that the RyR1 channel opening probability increased during hibernation. Dihydropyridine receptors protein expression and its co-localization with RYR1 decreased during hibernation prompts that the contractility of skeletal muscle was weakened. Protein expression of Ca<sup>2+</sup>-binding proteins calsequestrin1 and calmodulin increased indicating that the ability of intracellular free calcium binding increased during whole hibernation period. These findings confirm that the release, uptake, and binding of free Ca<sup>2+</sup> in the SR were enhanced in different skeletal muscles during hibernation. Up-regulation of muscular sarcoplasmic reticulum function protects skeletal muscle fibers against cytoplasmic calcium overload during hibernation in ground squirrels.</p>
Data on mitochondrial respiratory function in skeletal muscle of adult male mice in response to 3-weeks heat stress
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Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
<p>Spatial Transcriptomics Data of murine skeletal muscle undergoing reversible nerve injury. Accompanying the manuscript, D'Ercole et al. <strong>"Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle".</strong></p> <p> </p> <p><strong>Release v1: </strong>This release Includes all the code used to generate the figures and the processed and integrated original dataset in rds format.</p> <p> </p>
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
ClinicalTrials.gov study NCT05412888. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
ClinicalTrials.gov study NCT00943059. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Effect of Vitamin D on Skeletal Muscle Function and Qol in Patients With Chronic Intestinal Failure/Insufficiency
ClinicalTrials.gov study NCT06283615. IPD Sharing: NO. Countries: 1. Publications: 9.
Optimized Glycemic Control in Heart Failure Patients With DM2:"Effect on Left Ventricular Function and Skeletal Muscle"
ClinicalTrials.gov study NCT01213784. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
ClinicalTrials.gov study NCT02253732. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
ClinicalTrials.gov study NCT03283462. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Protein Ingestion on the Recovery of Skeletal Muscle Function Following Eccentric Exercise.
ClinicalTrials.gov study NCT02980900. IPD Sharing: NO. Countries: 1. Publications: 1.
Electrostimulation, Skeletal Muscle Function, and Exercise Capacity in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT00874965. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Influence of Severe Heart Failure to Function and Molecular Biological Parameters of Catabolism in the Human Diaphragm and Peripheral Skeletal Muscle
ClinicalTrials.gov study NCT02663115. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Epicatechin on Functional Capacity, Skeletal Muscle Structure and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction (HFPEF)
ClinicalTrials.gov study NCT02068040. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers
ClinicalTrials.gov study NCT04688177. IPD Sharing: UNDECIDED. Countries: 1. Publications: 57.
The Effect of Cigarette Smoking / Smoking Cessation on Skeletal Muscle Mass, Strength and Functional Capabilities
ClinicalTrials.gov study NCT02128048. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function
ClinicalTrials.gov study NCT05350566. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Functional Characteristic Properties of Skeletal Muscle Tissue Assessed by P31 Spectroscopy in Young and Older Adults
ClinicalTrials.gov study NCT03336294. IPD Sharing: NO. Countries: 1. Publications: 2.
The Study of Skeletal Muscle Function in Obstructive Sleep Apnea
ClinicalTrials.gov study NCT00813852. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.