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ShareScore release 0.9.0
Dataset results
23 results for “Skeletal remodeling”
Data from: The shoulder girdle of early chondrichthyans grew by skeletal remodelling
Open the record for dataset details and reuse information.
['"Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States"']
['"The annotation of the Affymetrix HTA 2.0 array was updated to optimise the detection of RNA in human skeletal muscle biopsy samples by removing invalid and low signal-high-variance probes (as for CDF GPL24047). The probes were then summarized into groups (probe-sets) reflecting either an ensembl full transcript identifier (FL-ENST, GPL24047) or just the probes targeting the 3\' UTR or the 5\' UTR of that particular ENST. Therefore, 3 different CDF were used to process the HTA 2.0 arrays in this study. Note that each CEL file was GC adjusted using APT while our custom CDF pipeline removes any probe that has >80% or <20% GC content (~50,000). The analysis was carried out only on the pairs of probe-sets i.e. FL-ENST vs 3\'UTR or FL-ENST vs 5\'UTR or 3\'UTR vs 5\'UTR. Dynamic muscle loading alters tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates identification of the underpinning molecular regulators. We present a within-person analysis strategy that reduced heterogeneity for changes in muscle mass by ~40% and employed a genome-wide transcriptome method that modeled each mRNA from coding exons and 3’/5’ untranslated (UTR) regions. Our strategy detected ~3-4 times more regulated genes than similarly sized studies, including substantial UTR-selective regulation that other methods would not detect. We discovered a core of 141 genes correlated to muscle growth validated from newly analyzed independent samples (n=100). Further validating these identified genes, via RNAi in primary muscle cells, we demonstrate that members of the core genes were regulators of protein synthesis e.g. Molecular Transducers of Physical Activity in Humans MoTrPAC. Employing proteome-constrained networks and pathway analysis revealed notable relationships with the molecular characteristics of human muscle aging and insulin sensitivity, as well as potential drug-therapies."']
Pax7 remodels the chromatin landscape in skeletal muscle stem cells
GEO Series GSE89977. Mus musculus. 42 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 transduced primary mouse myotubes ChIP-Seq)
GEO Series GSE273094. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Lactate Is a Metabolic–Epigenetic Signal That Links HIIT to miRNA-Centered Remodeling of the Skeletal-Muscle Methylome and Transcriptome [Methylation BeadChip]
GEO Series GSE308675. Mus musculus. 28 samples. Type: Methylation profiling by array.
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 transduced primary mouse myotubes RNA-Seq)
GEO Series GSE273093. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome
GEO Series GSE308674. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 skeletal muscle knockout RNA-Seq of unloading-reloading protocol)
GEO Series GSE273092. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Skeletal muscle TFEB overexpression transcriptionally remodels the mouse hippocampal landscape throughout lifespan in a sex-dependent manner [RNA-seq]
GEO Series GSE242361. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
A Zeb1/Mitochondrial Creatine Kinase Metabolic Axis Controls Osteoclast Activation and Skeletal Remodeling
GEO Series GSE212302. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Lactate Is a Metabolic–Epigenetic Signal That Links HIIT to miRNA-Centered Remodeling of the Skeletal-Muscle Methylome and Transcriptome
GEO Series GSE308673. Mus musculus. 29 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Skeletal Muscle Transcriptional Networks Linked to Motor Unit Remodeling in Human Parkinson’s Disease
GEO Series GSE128177. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
ClinicalTrials.gov study NCT05789433. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients
ClinicalTrials.gov study NCT00912938. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Short-term low calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults
GEO Series GSE103682. Homo sapiens. 16 samples. Type: Expression profiling by array.
Enhanced metabolic resilience and exercise adaptation of skeletal muscle in males by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture
GEO Series GSE280715. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States [CDF: Muscle_genome-build-id_ENST_binary]
GEO Series GSE155933. Homo sapiens. 230 samples. Type: Expression profiling by array.
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States [CDF: GC_M_HTA_3utr_Grch38,binary.cdf]
GEO Series GSE155959. Homo sapiens. 230 samples. Type: Expression profiling by array.
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States [CDF: GC_M_HTA_5utr_Grch38,binary.cdf]
GEO Series GSE155934. Homo sapiens. 230 samples. Type: Expression profiling by array.
Two weeks of high-intensity interval training increases skeletal muscle mitochondrial respiration via complex-specific remodeling in sedentary humans
GEO Series GSE221894. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.