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50 results for “Sodium channel;”
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
<p>The Brugada syndrome GWAS summary statistics</p> <p>Brugada syndrome is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of <em>SCN5A</em>, encoding the cardiac sodium channel Na<sub>V</sub>1.5, susceptibility genes remain largely unknown. We performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with Brugada syndrome and 10,001 controls.</p> <p> </p>
Fig. 1 in First report of kdr mutations in the voltage-gated sodium channel gene in the arbovirus vector, Aedes aegypti, from Nouakchott, Mauritania
Fig. 1 The combinations of kdr point mutations S989P, V1016G, and F1534C in adult female Aedes aegypti mosquitoes in Nouakchott, Mauritania
Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes
<p>Active electroreception — the ability to detect objects and communicate with conspecifics via the detection and generation of electric organ discharges (EODs) — has evolved convergently in several fish lineages. South American electric fishes (Gymnotiformes) are a highly species-rich group, possibly in part due to evolution of an electric organ (EO) that produces diverse EODs. Neofunctionalization of a voltage-gated sodium channel accompanied the evolution of electrogenic tissue from muscle and resulted in a novel gene (scn4aa) uniquely expressed in the EO. Here, we investigate the link between variation in scn4aa and differences in EOD waveform. We combine gymnotiform scn4aa sequences encoding the C-terminus of the Nav1.4a protein with biogeographic data and EOD recordings. We test whether physiological transitions among EOD types accompany differential selection pressures on scn4aa. We found positive selection on scn4aa coincided with shifts in EOD types. Species that evolved in the absence of predators, which likely selected for reduced EOD complexity, exhibited increased scn4aa evolutionary rates. We model mutations in the protein that may underlie changes in protein function and discuss our findings in the context of gymnotiform signalling ecology. Together, this work sheds light on the selective forces underpinning major evolutionary transitions in electric signal production.</p>
Electrophysiology Data for "Two functional epithelial sodium channel isoforms are present in rodents despite pronounced evolutionary pseudogenization and exon fusion"
<p>Here we provide the electrophysiology data for the manuscript "Two functional epithelial sodium channel isoforms are present in rodents despite pronounced evolutionary pseudogenization and exon fusion", published in Molecular Biology and Evolution (2021): msab271 (doi: 10.1093/molbev/msab271). Data are reported as current values in Excel format, sorted according to the appearance in Figures and supplemented by explanatory text on the procedures/data presentation.</p>
Inhibitor Masking Device & Sodium Channel, Voltage Gated, Type IX Alpha Subunit (SCN9) Gene Expression
ClinicalTrials.gov study NCT01412918. IPD Sharing: NO. Countries: 1. Publications: 1.
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
ClinicalTrials.gov study NCT01648205. IPD Sharing: NO. Countries: 1. Publications: 5.
Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes
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Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2
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Sex linkage of the skeletal muscle sodium channel gene (SCN4A) explains apparent deviations from Hardy–Weinberg equilibrium of tetrodotoxin-resistance alleles in garter snakes (Thamnophis sirtalis)
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Phylogenomics of scorpions reveal contemporaneous diversification of scorpion mammalian predators and mammal-active sodium channel toxins
<p>Scorpions constitute a charismatic lineage of arthropods and comprise more than 2,500 described species. Found throughout various tropical and temperate habitats, these predatory arachnids have a long evolutionary history, with a fossil record that began in the Silurian. While all scorpions are venomous, the asymmetrically diverse family Buthidae harbors nearly half the diversity of extant scorpions, and all but one of the 58 species that are medically significant to humans. However, the lack of a densely sampled scorpion phylogeny has hindered broader inferences of the diversification dynamics of scorpion toxins. As redress, we assembled a phylogenomic dataset of 100 scorpion venom transcriptomes and/or genomes, emphasizing the sampling of highly toxic buthid genera. To infer divergence times of venom gene families, we applied a phylogenomic node dating approach for the species tree in tandem with phylostratigraphic bracketing to estimate minimum ages of mammal-specific toxins. Our analyses establish a robustly supported phylogeny of scorpions, particularly with regard to relationships between medically significant taxa. Analysis of venom gene families shows that mammal-specific sodium channel toxins have independently evolved in five lineages within Buthidae. Temporal windows of mammal-specific toxin origins are correlated with the basal diversification of major scorpion mammal predators such as carnivores, shrews, bats and rodents. These results suggest an evolutionary model of relatively recent diversification of buthid sodium channel toxin (NaTx) homologs in response to diversification of scorpion predators.</p>
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium
<p>This dataset contains all patch clamp, confocal and mass spectrometry datasets of our publication 'Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium', published in BMC Biology. The data for each figure (fig 1-7) and supplementary figure (1-3) has been collected to an individual zipped folder. For additional information, please contact the corresponding author (Soile Nymark).</p>
Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer
ClinicalTrials.gov study NCT01916317. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes
ClinicalTrials.gov study NCT01804777. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sodium Channel Splicing in Heart Failure Trial (SOCS-HEFT) Prospective Study
ClinicalTrials.gov study NCT02738749. IPD Sharing: NO. Countries: 1. Publications: 7.
Sodium Channel Splicing in Heart Failure Trial
ClinicalTrials.gov study NCT01185587. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sodium Channel Splicing in Obstructive Sleep Apnea (SOCS-OSA)
ClinicalTrials.gov study NCT02725632. IPD Sharing: NO. Countries: 1. Publications: 3.
Phylogenomics of scorpions reveal contemporaneous diversification of scorpion mammalian predators and mammal-active sodium channel toxins
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Data from: The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation
Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) -mediated adhesion scaffolds trans-activating NaV1.5 (SCN5A) channels within narrow (V1.5. Smart patch clamp (SPC) indicated greater sodium current density (INa) at perinexi, relative to non-junctional sites. A novel, rationally designed peptide, βadp1, potently and selectively inhibited β1-mediated adhesion, in electric cell-substrate impedance sensing studies. βadp1 significantly widened perinexi in guinea pig ventricles, and selectively reduced perinexal INa, but not whol e cell INa, in myocyte monolayers. In optical mapping studies, βadp1 precipitated arrhythmogenic conduction slowing. In summary, β1-mediated adhesion at the perinexus facilitates action potential propagation between cardiomyocytes and may represent a novel target for anti-arrhythmic therapies.
Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5
<p>Source data underlying Figs 1b, 2b-c, 3b-c, 4a-d, and Supplementary Figs 3b-e, 4b-c, 5a-b</p>
Probing the Role of Sodium Channels in Painful Neuropathies
ClinicalTrials.gov study NCT02243475. IPD Sharing: Not stated. Countries: 0. Publications: 2.
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