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24 results for “Stenotrophomonas maltophilia”
Stenotrophomonas maltophilia_AB BIGb0135
This is one of the Wormbiome database archive files.<br>This entry includes all the genome annotation files related to Stenotrophomonas maltophilia_AB BIGb0135, a\(n\) Gammaproteobacteria.<br>The Wormbiome collection is an online database dedicated to centralizing all the information related to bacteria associated with C. elegans. More information on <a href="https://bitbucket.org/the-samuel-lab/wbm_scripts/src/master/DOCS/Annotations_output.md" target="_blank" rel="noopener noreferrer">the documentation page</a>.<br><br>
REPIN population analysis in 49 Stenotrophomonas maltophilia genomes
<p>This dataset contains the genome sequences of 49 S. maltophilia strains (input.zip) and the processed data from four individual RAREFAN runs. RAREFAN identifies RAYTs REPINS for each supplied genome and a reference genome. Four different strains where used as a reference genome: AA1, AB550 FDARGOOS_649, ISMMS3, and Sm53. The data were processed with default RAREFAN job parameters. Links to the original RAREFAN jobs are given below.</p>
Comparative whole genome phylogeny of animal, environmental and human strains confirms the genogroups organization and the diversity of Stenotrophomonas maltophilia
<p>Reannotation of Smc genomes from Refseq (Prokka v1.13) and gene presence and absence spreadsheet from Roary.</p>
SAXS data - FAD-dependent monooxygenase from Stenotrophomonas maltophilia
<p>Raw SAXS data for FAD-dependent monooxygenase from <em>Stenotrophomonas maltophilia</em> (<em>Sm</em>TetX) in h5z format. Detailed description is available in the manuscript "Tetracycline-modifying enzyme <em>Sm</em>TetX from <em>Stenotrophomonas maltophilia</em>".</p> <p>Processed data were deposited in the SASBDB database under the accession codes SASDPV7 and SASDPW7 for sample without and with reducing agent (30 mM DTT), respectively.</p> <p>https://www.sasbdb.org/data/SASDPV7<br> https://www.sasbdb.org/data/SASDPW7</p>
The effects of antibiotic combination treatments on Pseudomonas aeruginosa tolerance evolution and coexistence with Stenotrophomonas maltophilia
<p><em>Pseudomonas aeruginosa</em> bacterium is a common pathogen of Cystic Fibrosis (CF) patients due to its ability to evolve resistance to antibiotics during treatments. While <em>P. aeruginosa</em> resistance evolution is well characterised in monocultures, it is less well understood in polymicrobial CF infections. Here, we investigated how exposure to ciprofloxacin, colistin, or tobramycin antibiotics, administered at sub-MIC doses alone and in combination, shaped the tolerance evolution of <em>P. aeruginosa</em> (PAO1 lab and clinical CF LESB58 strains) in the absence and presence of a commonly co-occurring species, <em>Stenotrophomonas maltophilia</em>. Increases in antibiotic tolerances were primarily driven by the presence of that antibiotic in the treatment. We observed a reciprocal cross-tolerance between ciprofloxacin and tobramycin, and when combined these antibiotics selected increased MICs for all antibiotics. Though the presence of <em>S. maltophilia</em> did not affect the tolerance or the MIC evolution, it drove <em>P. aeruginosa</em> into extinction more frequently in the presence of tobramycin due to its relatively greater innate tobramycin tolerance. In contrast, <em>P. aeruginosa</em> dominated and drove <em>S. maltophilia</em> extinct in most other treatments. Together, our findings suggest that besides driving high-level antibiotic tolerance evolution, sub-MIC antibiotic exposure can alter competitive bacterial interactions, leading to target pathogen extinctions in multi-species communities.</p>
Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections
ClinicalTrials.gov study NCT05575427. IPD Sharing: NO. Countries: 1. Publications: 2.
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs
ClinicalTrials.gov study NCT03506191. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Description of Lung Transplant Patients With Microbiologically Documented Stenotrophomonas Maltophilia Pneumonia and Impact of Treatment on Outcome
ClinicalTrials.gov study NCT05193058. IPD Sharing: Not stated. Countries: 1. Publications: 7.
The effects of antibiotic combination treatments on Pseudomonas aeruginosa tolerance evolution and coexistence with Stenotrophomonas maltophilia
Open the record for dataset details and reuse information.
The 1.1 Å Structure of the Periplasmic Phosphate-Binding Protein from Stenotrophomonas maltophilia - a crystallisation contaminant identified by molecular replacement using the entire protein database (X-ray diffraction images).
<p>During efforts to crystallise the enzyme 2,4-dihydroxyacetophenone dioxygenase (DAD) from <em>Alcaligenes</em> sp. 4HAP, a small number of strongly diffracting protein crystals were obtained after two years of crystal growth in one condition. The crystals diffracted synchrotron radiation to almost 1.0 Å resolution and were, until recently, assumed to be formed by the DAD protein. However, when another crystal form of this enzyme was eventually solved at lower resolution, molecular replacement using this structure as the search model did not give a convincing solution with the original atomic resolution dataset. Hence we considered that these crystals might be due to a protein impurity, although molecular replacement using the structures of common crystallisation contaminants as search models again failed. A script to perform molecular replacement using MOLREP (Vagin, A. & Teplyakov, A. (2010). Acta Crystallogr. D 66, 22-25.) in which the first chain of every structure in the PDB was used as a search model was run on a multi-core cluster. This identified a number of prokaryotic phosphate binding proteins as scoring highly in the MOLREP peak lists. Calculation of an electron density map at 1.1 Å resolution allowed most of the amino acids to be identified visually and built into the model. A BLAST search then indicated that the molecule was most probably a phosphate binding protein from <em>Stenotrophomonas maltophilia</em> (UniProt ID: B4SL31; gene ID: Smal_2208) and fitting of the corresponding sequence to the atomic resolution map fully corroborated this. Proteins in this family have been linked with the virulence of antibiotic resistant strains of pathogenic bacteria and with biofilm formation. The structure has been refined to an R-factor of 10.15 % and an R-free of 12.46 % at 1.1 Å resolution. The molecule adopts the type-II periplasmic binding protein fold with a number of extensively elaborated loop regions. A fully-dehydrated phosphate anion is bound tightly between the two domains of the protein and interacts with conserved residues and a number of helix dipoles. </p>
Fosfomycin and the intermediate metabolites PEP and GA-3P effect on Stenotrophomonas maltophilia transcriptome
GEO Series GSE181918. Stenotrophomonas maltophilia. 13 samples. Type: Expression profiling by high throughput sequencing.
Pseudomonas aeruginosa promotes persistence of Stenotrophomonas maltophilia via increased adherence to depolarized respiratory epithelium
GEO Series GSE216847. Mus musculus; Stenotrophomonas maltophilia. 26 samples. Type: Expression profiling by high throughput sequencing.
Stenotrophomonas maltophilia differential gene expression in synthetic cystic fibrosis sputum identifies shared and cystic fibrosis strain-specific expression responses to the sputum environment
GEO Series GSE125704. Stenotrophomonas maltophilia. 12 samples. Type: Expression profiling by high throughput sequencing.
A novel TetR-like transcriptional regulator in Stenotrophomonas maltophilia is involved in fatty acid metabolism, including quorum sensing signal turnover
GEO Series GSE206554. Stenotrophomonas maltophilia K279a. 6 samples. Type: Expression profiling by high throughput sequencing.
Trimethoprim-Sulfamethoxazole vs Levofloxacin as Targeted Therapy for Stenotrophomonas Maltophilia Infections: a Retrospective Cohort Study
ClinicalTrials.gov study NCT04639817. IPD Sharing: NO. Countries: 1. Publications: 0.
Alternative Treatment Strategies for Stenotrophomonas Maltophilia Pneumonia
ClinicalTrials.gov study NCT06112938. IPD Sharing: NO. Countries: 1. Publications: 0.
Antibiotic Treatment for Pneumonia Caused by Stenotrophomonas Maltophilia in ICU Patients
ClinicalTrials.gov study NCT07052604. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Half-lives mRNA analysis of Stenotrophomonas maltophilia D457 and rng-deficient mutant
GEO Series GSE103467. Stenotrophomonas maltophilia. 8 samples. Type: Expression profiling by high throughput sequencing.
Global transcriptome analysis of Stenotrophomonas maltophilia in response to human body temperature
GEO Series GSE101926. Stenotrophomonas maltophilia. 6 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic heterogeneity affects Stenotrophomonas maltophilia K279a colony morphotypes and β-lactamase expression
GEO Series GSE71735. Stenotrophomonas maltophilia K279a. 10 samples. Type: Expression profiling by high throughput sequencing.
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