Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
245
datasets available to search
ShareScore release 0.9.0
Dataset results
245 results for “Streptococcus pneumoniae”
Input data for running a GWAS on penicillin resistance in Streptococcus pneumoniae
<p>Results from running the pyseer tutorial at https://pyseer.readthedocs.io/en/master/tutorial.html</p>
Figure 1 in Colonization by Streptococcus pneumoniae among children in Porto Velho, Rondônia, Western Brazilian Amazon
Figure 1. Location of the study area.
DivIVA controls the dynamics of septum splitting and cell elongation in Streptococcus pneumoniae
<ul> <li>Raw phase contrast and fluorescence images to analyze the localization of DivIVA-HT in <em>Streptococcus pneumoniae</em>.</li> <li>Raw phase contrast and fluorescence images to analyze the localization of GFP-aPBP1a in <em>Streptococcus pneumoniae </em>wild-type and D<em>divIVA</em> cells.<em><br></em></li> <li>Raw phase contrast and fluorescence images to analyze the localization of GFP-aPBP2a in <em>Streptococcus pneumoniae </em>wild-type and D<em>divIVA</em> cells.</li> <li>Raw bright field (BF), diffraction-limited (DL) and reconstructed dSTORM images to analyze peptidoglycan synthesis in <em>S. pneumoniae </em>wild-type and mutant cells (D<em>divIVA</em>, D<em>pbp1a, </em>D<em>pbp2a, </em>D<em>pbp2b mltG(Y488D)</em>.</li> </ul>
Nasopharyngeal Carriage, Antimicrobial Resistance, and Serotype Distribution of Streptococcus pneumoniae in Children Under Five in Lebanon: Baseline Data Prior to PCV13 Introduction
<p>Dataset and R Code Script</p>
dSTORM imaging of Streptococcus pneumoniae using fluorescent d-amino acids
<p>Please see more details in the readme file.</p>
Epithelial Micro-Invasion Events by Streptococcus pneumoniae Drives Unique Epithelial Cell Responses
<p>RNA Sequencing dataset for Weight et al Manuscript.</p>
Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults
ClinicalTrials.gov study NCT01537185. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dual randomly barcoded transposon sequencing (Dual Tn-seq) data for <em>Streptococcus pneumoniae</em> D39
Open the record for dataset details and reuse information.
Data from: Oxidative killing of encapsulated and nonencapsulated Streptococcus pneumoniae by lactoperoxidase-generated hypothiocyanite
<p class="CxSpFirst"><i>Streptococcus pneumoniae</i> (Pneumococcus) infections affect millions of people worldwide, cause serious mortality and represent a major economic burden. Despite recent successes due to pneumococcal vaccination and antibiotic use, Pneumococcus remains a significant medical problem. Airway epithelial cells, the primary responders to pneumococcal infection, orchestrate an extracellular antimicrobial system consisting of lactoperoxidase (LPO), thiocyanate anion and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). LPO oxidizes thiocyanate using H<sub>2</sub>O<sub>2</sub> into the final product hypothiocyanite that has antimicrobial effects against a wide range of microorganisms. However, hypothiocyanite's effect on Pneumococcus has never been studied. Our aim was to determine whether hypothiocyanite can kill <i>S. pneumoniae.</i> Bactericidal activity was measured in a cell-free <i>in vitro </i>system by determining the number of surviving pneumococci via colony forming units on agar plates, while bacteriostatic activity was assessed by measuring optical density of bacteria in liquid cultures. Our results indicate that hypothiocyanite<sup> </sup>generated by LPO exerted robust killing of both encapsulated and nonencapsulated pneumococcal strains. Killing of <i>S. pneumoniae</i> by a commercially available hypothiocyanite-generating product was even more pronounced than that achieved with laboratory reagents. Catalase, an H<sub>2</sub>O<sub>2</sub> scavenger, inhibited killing of pneumococcal by hypothiocyanite under all circumstances. Furthermore, the presence of the bacterial capsule or lytA-dependent autolysis had no effect on hypothiocyanite-mediated killing of pneumococci. On the contrary, a pneumococcal mutant deficient in pyruvate oxidase (main bacterial H<sub>2</sub>O<sub>2</sub> source) had enhanced susceptibility to hypothiocyanite compared o its wild-type strain. Overall, results shown here indicate that numerous pneumococcal strains are susceptible to LPO-generated hypothiocyanite.</p>
Data from: Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae
Streptococcus pneumoniae is common nasopharyngeal commensal bacterium and important human pathogen. Vaccines against a subset of pneumococcal antigenic diversity have reduced rates of disease, without changing the frequency of asymptomatic carriage, through altering the bacterial population structure. These changes can be studied in detail through using genome sequencing to characterise systematically-sampled collections of carried S. pneumoniae. This dataset consists of 616 annotated draft genomes of isolates collected from children during routine visits to primary care physicians in Massachusetts between 2001, shortly after the seven valent polysaccharide conjugate vaccine was introduced, and 2007. Also made available are a core genome alignment and phylogeny describing the overall population structure, clusters of orthologous protein sequences, software for inferring serotype from Illumina reads, and whole genome alignments for the analysis of closely-related sets of pneumococci. These data can be used to study both bacterial evolution and the epidemiology of a pathogen population under selection from vaccine-induced immunity.
Streptococcus Pneumoniae ST556 Vs Mycoplasma Pneumoniae M129 genome by Blastn analysis
<p><strong>Introduction:</strong> The overlap between Streptococcus pneumoniae and Mycoplasma pneumoniae genome was studied by Blastn analysis. Mycoplasma is an intracellular pathogen causing pneumonia with staccato cough, predominantly handled by T cell immunity. </p><p><strong>Methods:</strong> Through the NCBI website, the overlap of genome sequences of Streptococcus pneumoniae Taiwan (PT 306), and mycoplasma pneumoniae were studied using Blastn. The accession number for the Streptococcus pneumoniae ST556 was CP003357, and the Mycoplasma pneumoniae strain M129 was U00089, respectively. DNA alignments and nucleotide overlapping alignment sequences were studied.</p><p><strong>Results:</strong> There were significant overlaps between the genome sequences of these two organisms by blastn. The overlapping sequences and dot analysis are shown in the files attached in this accompanying document. The overlapping nucleotides involved with high significance (expect values = 0.0).</p><p><strong>Conclusion:</strong> There are overlaps in genome sequences between Streptococcus pneumoniae and mycoplasma genomes. Further studies are required to study the significance of the COVID-19 context and the recent outbreak of mycoplasma in the community across various countries. The overlap can throw some ideas of the use of the potential of streptococcus pneumoniae vaccines for prevention. If not a prevention Streptococcus pneumonia vaccinations can facilitate a deceleration in the spread of mycoplasma infections.</p><p> </p>
Streptococcus Pneumoniae Nasopharyngeal Carriage
ClinicalTrials.gov study NCT01485029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT01908283. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Serological Response to Antipneumococcal Vaccination and Impact on Streptococcus Pneumoniae Nasal Carriage in HIV Adults
ClinicalTrials.gov study NCT02123433. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers
ClinicalTrials.gov study NCT02888457. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety, Tolerability, Efficacy and Pharmacodynamics of CAL02 in Severe Pneumonia Caused by Streptococcus Pneumoniae
ClinicalTrials.gov study NCT02583373. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Data from: Oxidative killing of encapsulated and nonencapsulated Streptococcus pneumoniae by lactoperoxidase-generated hypothiocyanite
Open the record for dataset details and reuse information.
Data from: Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae
Open the record for dataset details and reuse information.
Data from: Competence increases survival during stress in Streptococcus pneumoniae.
Horizontal gene transfer mediated by transformation is of central importance in bacterial evolution. However, numerous questions remain about the maintenance of processes that underlie transformation. Most hypotheses for the benefits of transformation focus on what bacteria might do with DNA, but ignore the important fact that transformation is subsumed within the broader process of competence. Accordingly, the apparent benefits of transformation might rely less on recombination than on other potential benefits associated with the broader suite of traits regulated by competence. We examined the importance of this distinction in the naturally competent species Streptococcus pneumoniae, focussing specifically on predictions of the DNA-for-repair hypothesis. We confirm earlier results in other naturally competent species that transformation protects against DNA-damaging stress. In addition, we show that the stress-protection extends to non-DNA-damaging stress. More important, we find that for some forms of stress transformation is not required for cells to benefit from the induction of competence. This rejects the narrowly defined DNA-for-repair hypotheses and provides the first support for Claverys' hypothesis that competence, but not necessarily transformation, may act as a general process to relieve stress. Our results highlight the need to distinguish benefits of transformation from broader benefits of competence that do not rely on DNA uptake and recombination.
Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of Streptococcus pneumonia.
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.