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ShareScore release 0.9.0
Dataset results
18 results for “Stress barrier”
Role of the Blood-Brain Barrier in Stress Resilience: Investigating New Pathways Towards Pharmacological Augmentation of Stress Resilience
ClinicalTrials.gov study NCT06965868. IPD Sharing: YES. Countries: 3. Publications: 4.
Data from: Exposure effects beyond the epithelial barrier: trans-epithelial induction of oxidative stress by diesel exhaust particulates in lung fibroblasts in an organotypic human airway model
<p><i>In vitro</i> bronchial epithelial monoculture models have been pivotal in defining the adverse effects of inhaled toxicant exposures; however, they are only representative of one cellular compartment and may not accurately reflect the effects of exposures on other cell types. Lung fibroblasts exist immediately beneath the bronchial epithelial barrier and play a central role in lung structure and function, as well as disease development and progression. We tested the hypothesis that <i>in vitro</i> exposure of a human bronchial epithelial cell barrier to the model oxidant diesel exhaust particulates caused trans-epithelial oxidative stress in the underlying lung fibroblasts using a human bronchial epithelial cell and lung fibroblast co-culture model. We observed that diesel exhaust particulates caused trans-epithelial oxidative stress in underlying lung fibroblasts as indicated by intracellular accumulation of the reactive oxygen species hydrogen peroxide, oxidation of the cellular antioxidant glutathione, activation of NRF2, and induction of oxidative stress responsive genes. Further, targeted antioxidant treatment of lung fibroblasts partially mitigated the oxidative stress response gene expression in adjacent human bronchial epithelial cells during diesel exhaust particulate exposure. This indicates that exposure induced oxidative stress in the airway extends beyond the bronchial epithelial barrier and that lung fibroblasts are both a target and a mediator of the adverse effects of inhaled chemical exposures despite a lack of direct exposure to the inhaled material. These findings illustrate the value of co-culture models and suggest that trans-epithelial exposure effects should be considered in inhalation toxicology research and testing.</p>
Motivation and Barriers for Exercise in Patients With Anxiety or Posttraumatic Stress Disorder
ClinicalTrials.gov study NCT03818425. IPD Sharing: NO. Countries: 1. Publications: 1.
Skydiving as a Model of Psychological Stress and Its Effect on Intestinal Barrier Function
ClinicalTrials.gov study NCT03644979. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Exposure effects beyond the epithelial barrier: trans-epithelial induction of oxidative stress by diesel exhaust particulates in lung fibroblasts in an organotypic human airway model
Open the record for dataset details and reuse information.
Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB path
GEO Series GSE183662. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cellular stress, inflammation and barrier damage in gut epithelial cells caused by aspartame
GEO Series GSE285905. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Dolutegravir Disrupts Mouse Blood-Brain Barrier by Inducing Endoplasmic Reticulum Stress
GEO Series GSE285595. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Study on Correlated Factors of Barrier and Immune Function in Stress Related Mucosal Disease (SRMD)
ClinicalTrials.gov study NCT03200158. IPD Sharing: NO. Countries: 1. Publications: 0.
Skin Barrier Abnormalities and Oxidative Stress Response
ClinicalTrials.gov study NCT04606615. IPD Sharing: NO. Countries: 1. Publications: 0.
Rutin ameliorates stress-induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin-5 axis
GEO Series GSE288810. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Metabolic stress is a barrier to Epstein-Barr virus mediated B-cell immortalization
GEO Series GSE76137. Homo sapiens. 6 samples. Type: Expression profiling by array.
Modeling the effects of acute and chronic oxidative stress on blood-brain barrier phenotype and function in 2D and 3D
GEO Series GSE193887. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
GEO Series GSE107941. Mus musculus. 21 samples. Type: Expression profiling by array.
Sex-specific blood-brain barrier alterations and vascular biomarkers underlie chronic stress responses in mice and human depression.
GEO Series GSE173823. Mus musculus. 67 samples. Type: Expression profiling by array.
Transcriptional Responses of in vitro Blood-Brain Barrier Models to Shear Stress
GEO Series GSE277559. Rattus norvegicus; Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
The cross-talk between DNA damage, oxidative stress and epidermal barrier in keratinocytes after exposure to particulate matters and carbon black
GEO Series GSE206862. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies
ClinicalTrials.gov study NCT01417416. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.