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32 results for “Synovial Joints”
Evaluation of synovial calprotectin by using a lateral flow stool test for the diagnosis of prosthetic joint infections
<p>The analysis of synovial fluid is a crucial step in the diagnostic process of prosthetic joint infections (PJI) and several studies illustrated the efficacy of synovial calprotectin in supporting the diagnosis of PJI. In this study, synovial calprotectin was analyzed by a commercial stool test to explore whether the detected levels might predict PJIs. The synovial fluids of 55 were analyzed. Calprotectin levels were compared to other synovial biomarkers of PJI. Of the 55 synovial fluids, 13 patients were diagnosed with PJI and 42 with an aseptic failure of the implant. The specificity, sensitivity, and AUC of calprotectin resulted 0.90, 0.85, and 0.86 (95%CI: 0.72-0.99), respectively with a set threshold of 226.5 µg/g. The values of calprotectin had a moderate and statistically relevant correlation with the synovial leucocyte counts (rs = 0.54, p = 0.0003) and percentage of synovial neutrophils (rs = 0.68, p = 0.0000). From this analysis, it can be concluded that synovial calprotectin is a valuable biomarker that correlates with other established indicator of local infection, and the use of a commercial lateral flow stool test could be a cost-effective strategy delivering rapid and reliable results and supporting the diagnostic process of PJI.</p>
Data from: Joint histology in Alligator mississippiensis challenges the identification of synovial joints in fossil archosaurs and inferences of cranial kinesis
Archosaurs, like all vertebrates, have different types of joints that allow or restrict cranial kinesis, such as synovial joints and fibrous joints. In general, synovial joints are more kinetic than fibrous joints, because the former possess a fluid-filled cavity and articular cartilage that facilitate movement. Even though there is a considerable lack of data on the microstructure and the structure–function relationships in the joints of extant archosaurs, many functional inferences of cranial kinesis in fossil archosaurs have hinged on the assumption that elongated condylar joints are (i) synovial and/or (ii) kinetic. Cranial joint microstructure was investigated in an ontogenetic series of American alligators, Alligator mississippiensis. All the presumably synovial, condylar joints found within the head of the American alligator (the jaw joint, otic joint and laterosphenoid–postorbital (LS–PO) joint) were studied by means of paraffin histology and undecalcified histology paired with micro-computed tomography data to better visualize three-dimensional morphology. Results show that among the three condylar joints of A. mississippiensis, the jaw joint was synovial as expected, but the otherwise immobile otic and LS–PO joints lacked a synovial cavity. Therefore, condylar morphology does not always imply the presence of a synovial articulation nor mobility. These findings reveal an undocumented diversity in the joint structure of alligators and show that crocodylians and birds build novel, kinetic cranial joints differently. This complicates accurate identification of synovial joints and functional inferences of cranial kinesis in fossil archosaurs and tetrapods in general.
Draining PLN and Synovial Inflammation in RA Knee Joints Pre and Post Anti-TNF or B Cell Depletion Therapy
ClinicalTrials.gov study NCT01083563. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers
ClinicalTrials.gov study NCT04858217. IPD Sharing: NO. Countries: 1. Publications: 18.
Data from: Joint histology in Alligator mississippiensis challenges the identification of synovial joints in fossil archosaurs and inferences of cranial kinesis
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Data from: MFAP5 contributes to inflammation, synovial hyperplasia and joint damage in rheumatoid arthritis via integrin-ERK signaling
<p>Synovial hyperplasia is the primary pathological changes of RA and FLS is the principal etiological cellular component that drives and constitutes the pathological lesions. To elucidate the molecular mechanism of how FLS may contribute to RA, we performed transcriptome profiling to determine the DEGs between normal and RA FLS. We compared the primary FLS isolated from healthy control (HFLS) to that isolated from RA patients (RA FLS), and also to an immortalized RA FLS cell line MH7A immortalized by stably transfecting primary RA FLS cells with SV40 T antigen gene. </p>
Data from: MFAP5 contributes to inflammation, synovial hyperplasia and joint damage in rheumatoid arthritis via integrin-ERK signaling
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scRNAseq gene expression profile of zebrafish jaw joint cells after complete resection of the synovial jaw joint
GEO Series GSE283763. Danio rerio. 15 samples. Type: Expression profiling by high throughput sequencing.
PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development [scRNA-seq]
GEO Series GSE289874. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Locally renewing resident synovial macrophages provide a protective barrier for the joint [RNA-seq]
GEO Series GSE134286. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Critical Role of Synovial Tissue-resident Macrophage Niche in Joint Homeostasis and Suppression of Chronic Inflammation
GEO Series GSE158446. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Locally renewing resident synovial macrophages provide a protective barrier for the joint [scRNA-seq]
GEO Series GSE134420. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
GEO Series GSE214500. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
DRG bulk RNAseq: Repeated Injections Of Intra-articular Nerve Growth Factor Into The Naive Murine Knee Joint Cause Synovial Inflammation, Knee Sensitization, And Neuronal Sprouting
GEO Series GSE287526. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Profiling of IL-17A-treated Synovial Fibroblasts from the Human Temporomandibular Joint
GEO Series GSE74668. Homo sapiens. 2 samples. Type: Expression profiling by array.
Locally renewing resident synovial macrophages provide a protective barrier for the joint
GEO Series GSE134691. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection
ClinicalTrials.gov study NCT03038464. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Clinical Study of Magnetic Resonance Imaging and Deep Learning of Joint Synovial Disease
ClinicalTrials.gov study NCT04952896. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid
ClinicalTrials.gov study NCT02868736. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Profiling of Stem/Progenitor Cell Regulatory Genes of the Synovial Joint by Genome-wide RNASeq Analysis
GEO Series GSE113116. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.