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721 results for “Systemic lupus erythematosus”
Memory B Cells and Their Transcriptomic Profiles Associated with Belimumab Resistance in Systemic Lupus Erythematosus in the Maintenance Phase
<p>Normalized count of RNA sequences from systemic lupus erythematosus patients treated with belimumab.</p> <p>We collected blood samples from patients with systemic lupus erythematosus (n=44) before and approximately 3 and 6 months after treatment by belimumab, respectively. We also included healthy individuals (n=17). There were no missing samples in the before-treatment specimen for 44 patients; however, five samples were missing at the three-month time, and four were missing at the six-month time after treatment. Whole blood samples were stored in PAXgene tubes (QUIAGEN). RNA was extracted by PAXgene Blood RNA Kit (QUIAGEN). Library preparation was performed using TruSeq stranded Total RNA Library PrepKit with Ribo-Zero Globin Human. Sequencing was conducted by NovaSeq6000 in the 100-bp paired-end mode. Sequencing reads were trimmed using Trimmomatic ver. 0.36 (leading: 20, trailing: 20, slidingwindow: 4:15, minlen: 36) and aligned to hg38 reference genome using STAR (ver. 2.7.3a). Gene counts were generated by RSEM (ver. 1.3.1) using Homo_sapiens.GRCh38.95.gtf from the Ensembl database. Gene counts were normalized by size factor implemented in DESeq2 and converted to count per million (CPM), and log<sub>2</sub>(CPM+1) was calculated. </p> <p>Sample names starting with 'R_' indicate responders, while those ending with '_NR' indicate non-responders. '0M' represents before treatment, '3M' represents three months after treatment, and '6M' represents six months after treatment. The numeric ID, excluding the last two characters, represents individual patients.</p> <p> </p> <p>If you use this data, please cite Iwasaki et al. Front. Immunol., 04 February 2025 <a href="https://doi.org/10.3389/fimmu.2025.1506298">https://doi.org/10.3389/fimmu.2025.1506298</a></p>
Aerobic Exercise in Women With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT03186794. IPD Sharing: YES. Countries: 1. Publications: 3.
Dipyridamole Assessment for Flare Reduction in Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT01781611. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Evaluate the Efficacy and Safety of Sifalimumab in Adults With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT01283139. IPD Sharing: Not stated. Countries: 22. Publications: 3.
Efficacy and Safety of Belimumab in Black Race Patients With Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT01632241. IPD Sharing: YES. Countries: 6. Publications: 4.
A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE
ClinicalTrials.gov study NCT03312907. IPD Sharing: YES. Countries: 11. Publications: 5.
Study of BOS161721 in Systemic Lupus Erythematosus (SLE) Patients on a Background of Limited Standard of Care
ClinicalTrials.gov study NCT03371251. IPD Sharing: Not stated. Countries: 12. Publications: 1.
A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT01597492. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT04294667. IPD Sharing: YES. Countries: 25. Publications: 0.
Safety and Efficacy Study of a Biologic to Treat Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT02265744. IPD Sharing: Not stated. Countries: 23. Publications: 1.
A Phase 2a of RSLV-132 in Subjects With Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT02660944. IPD Sharing: NO. Countries: 1. Publications: 1.
A Continuation Trial for Subjects With Systemic Lupus Erythematosus That Have Completed Protocol LBSL02
ClinicalTrials.gov study NCT00583362. IPD Sharing: YES. Countries: 2. Publications: 2.
Cyclophosphamide and Rabbit Antithymocyte Globulin (rATG)/Rituximab in Patients With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT00278538. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)
ClinicalTrials.gov study NCT00624338. IPD Sharing: Not stated. Countries: 29. Publications: 3.
A Study of the Effect of XmAb®5871 in Patients With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT02725515. IPD Sharing: NO. Countries: 1. Publications: 3.
Biomarkers of Lupus Disease: Serial Biomarker Sampling in Patients With Active Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT00987831. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Four Doses of Cenerimod Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT03742037. IPD Sharing: NO. Countries: 24. Publications: 2.
Development of a Dietary Intervention Model Based on Genetic Data as an Implementation of a Healthy Lifestyle in the Management of Systemic Lupus Erythematosus Patients
ClinicalTrials.gov study NCT07183007. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Efavaleukin Alfa in Subjects With Active Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT04680637. IPD Sharing: YES. Countries: 19. Publications: 1.
An Investigational Study to Evaluate BMS-986165 in Participants With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT03252587. IPD Sharing: Not stated. Countries: 17. Publications: 3.
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