Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
66
datasets available to search
ShareScore release 0.9.0
Dataset results
66 results for “T helper 17”
Role of T Helper 17 and Regulatory T Cells in Delayed Graft Function
ClinicalTrials.gov study NCT01232816. IPD Sharing: NO. Countries: 1. Publications: 1.
Raw data relative to: "Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients"
<p><strong>Introduction</strong></p> <p> Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS. Indeed, Th17 cells are abundant in the cerebrospinal fluid and peripheral blood of MS patients and promote pathogenesis in the mouse model of MS. To gain insight into the function of Th17 cells in MS, we tested whether Th17 cells polarized from naïve CD4 T cells of healthy donors and MS patients display different features</p> <p><strong>Methods</strong></p> <p>We analysed several parameters that typify the Th17 profile during the differentiation process of naïve CD4 T cells obtained from relapsing-remitting (RR)-MS patients and healthy donors (HD), such as expression of surface receptors by flow cytometry.</p> <p><strong>Results</strong></p> <p>The analysis revealed that expression of IL-1R1 is significantly increased in Th17 cells derived from MS patients compared to healthy donor-derived cells. Interestingly, IL-1R1 expression is also increased in Th17 cells circulating in the blood of MS patients compared to healthy donors. Since IL-1R1 play a crucial role in the activation of immune cells, our data indicate that high expression of these molecules in Th17 cells from MS patients could be related to their high inflammatory status.</p>
Raw data related to: "Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases"
<p><strong>Introduction</strong></p> <p>T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression of retinoic acid-receptor (RAR)-related orphan receptor (ROR)γt transcription factor, encoded by gene <em>Rorc</em>. These cells are implicated in the pathology of autoimmune inflammatory disorders as well as in the clearance of extracellular infections. The main function of Th17 cells is the production of cytokine called interleukin (IL)-17A.</p> <p><strong>Methods</strong></p> <p>We described the lineage defining transcription factor RORγt and other factors that regulate transcription of <em>Il17a, Rorc </em>and Th17-related genes, such as Il17f, Il21, Il23r, which may positively or negatively influence their expression.</p> <p><strong>Results</strong></p> <p>We discussed the potential new therapeutic approaches for Th17-related diseases targeting these transcription factors. The wide knowledge of transcriptional regulators of Th17 cells is crucial for the better understanding of the pathogenic role of these cells and for development of therapeutic strategies aimed at fighting Th17-related diseases.</p>
Mint-ChIP-seq from T-helper 17 cell (ENCSR079EXG)
GEO Series GSE208515. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Temporal programming of T-helper 17 (TH17) cell differentiation by SAA1+IL6 measured by RNA-Seq
GEO Series GSE132761. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Mint-ChIP-seq from activated T-helper 17 cell (ENCSR989FGD)
GEO Series GSE209071. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of RNAs bound by DDX5 and RORgt in cultured T helper 17 cell [ChIRP-Seq]
GEO Series GSE73912. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
total RNA-seq from activated T-helper 17 cell (ENCSR964JRR)
GEO Series GSE219947. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Mint-ChIP-seq from T-helper 17 cell (ENCSR103GBF)
GEO Series GSE208797. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ATAC-seq from T-helper 17 cell (ENCSR611BQR)
GEO Series GSE187657. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Control Mint-ChIP-seq from activated T-helper 17 cell (ENCSR122NDV)
GEO Series GSE208896. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of chromatin loci bound by DDX5 in cultured T helper 17 cell [ChIP-Seq]
GEO Series GSE73913. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
total RNA-seq from activated T-helper 17 cell (ENCSR265EHG)
GEO Series GSE219653. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
DNase-seq from T-helper 17 cell (ENCSR537TXP)
GEO Series GSE187599. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells [RNA-seq]
GEO Series GSE113720. Mus musculus. 99 samples. Type: Expression profiling by high throughput sequencing.
Single cell transcriptome and surface protein expression analysis identify OX40+GITR+ pathogenic T helper 17 in anklyosing spondilytis [CITE-seq]
GEO Series GSE216884. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Single cell transcriptome and surface protein expression analysis identify OX40+GITR+ pathogenic T helper 17 in anklyosing spondilytis.
GEO Series GSE216885. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from T-helper 17 cell (ENCSR831GLL)
GEO Series GSE219812. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Mint-ChIP-seq from T-helper 17 cell (ENCSR560ONA)
GEO Series GSE209022. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mint-ChIP-seq from T-helper 17 cell (ENCSR982WMJ)
GEO Series GSE209058. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.