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81 results for “TGF-β signaling”
Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
The Antarctic icefish, a family (Channichthyidae) of teleosts within the perciform suborder Notothenioidei, are the only known vertebrates without oxygen-transporting haemoglobins and that are largely devoid of circulating erythrocytes. To elucidate the evo-devo mechanisms underpinning the suppressed erythropoiesis in the icefish, we conducted comparative studies on the transcriptomes and microRNAomes of the primary haematopoietic tissues between an icefish (Chionodraco hamatus) and two red-blooded notothenioids (Trematomus bernacchii and Gymnodraco acuticeps). We identified substantial remodelling of the haematopoietic programs in the icefish through which erythropoiesis is selectively suppressed. Experimental verification showed that erythropoietic suppression in the icefish may be attributable to the upregulation of TGF-β signalling, which coincides with reductions in multiple transcription factors essential for erythropoiesis and the upregulation of hundreds of microRNAs, the majority (> 80%) of which potentially target erythropoiesis regulating factors. Of the six microRNAs selected for verification, three miRNAs (miR-152, miR-1388 and miR-16b) demonstrated suppressive functions on GATA1 and ALAS2, which are two factors important for erythroid differentiation, resulting in reduced numbers of erythroids in microinjected zebra fish embryos. Codon substitution analyses of the genes of the TGF-β superfamily revealed signs of positive selection in TGF-β1 and endoglin in the lineages leading to Antarctic notothenioids. Both genes are previously known to function in erythropoietic suppression. These findings implied a general trend of erythropoietic suppression in the cold-adapted notothenioid lineages through evolutionary modulation of the multi-functional TGF-β signalling pathway. This trend is more pronounced in the haemoglobin-less icefish, which may pre-emptively hinder the otherwise defective erythroids from production.
Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
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Remodeling of the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling
GEO Series GSE195686. Homo sapiens; Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma
GEO Series GSE169029. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
TGF-β/Nodal signaling boosts glucose uptake during mesendoderm differentiation by inducing a transmembrane micropeptide
GEO Series GSE157073. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics. [ATAC-seq]
GEO Series GSE110576. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells
GEO Series GSE78032. Homo sapiens. 12 samples. Type: Expression profiling by array.
Remodeling of the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling [bulk RNA-seq]
GEO Series GSE195685. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
TGF-β Signaling Pathway and Cell-Cell Interactions in the Tumor Microenvironment Drive Bladder Cancer Progression after BCG Instillation Treatment: Insights from longitudinal Single-Nucleus RNA-Seq
GEO Series GSE270296. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
TGF-β signaling mediates microglial resilience to age-dependent dorsal column myelin alterations
GEO Series GSE254915. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics. [RNA-seq]
GEO Series GSE110309. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
SMAD nucleocytoplasmic shuttling relies on nucleoporin RanBP2 and VIM-AS1 long non-coding RNA during TGF-β signaling
GEO Series GSE281521. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signalling and malignant features in vitro and in vivo
GEO Series GSE104193. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling [RNA-seq]
GEO Series GSE175845. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Modulation of Syndecan-1/4 reduces the invasive potential of endometrioma through TGF-β signalling
GEO Series GSE135122. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
TGF-β signaling controls neural crest developmental plasticity via SMAD2/3 [TGF-β KD RNA-seq]
GEO Series GSE278071. Gallus gallus. 6 samples. Type: Expression profiling by high throughput sequencing.
Histone H3 Lysine 27 methylation Regulates Skeletal Growth by Suppressing Wnt and TGF-β Signaling
GEO Series GSE76467. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Maladaptive TGF-β Signals to the Alveolar Epithelium Drive Fibrosis after COVID-19 Infection
GEO Series GSE224955. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Butyrate protects against diet-induced liver fibrosis and suppresses non-canonical TGF-β signaling in human stellate cells
GEO Series GSE179395. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.
GEO Series GSE237403. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.