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134 results for “THC”
Impact of prenatal THC exposure on mouse brain development; a lifespan approach with MRI
<p>Prenatal cannabis exposure has been demonstrated to impact neurodevelopment in offspring at different ages. To date, to our knowledge, no study has longitudinally examined the effects from embryos to adulthood. Here we collected and analyzed data to explore how prenatal exposure to delta-9-tetrahydrocannabinol (5 mg/kg subcutaneous injections, gestational dat [GD] 3-10) in mice impacts trajectories of brain development with structural magnetic resonance imaging. We supplement these findings with behavioural analyses and electron microscopy as described below.</p> <p>In the first cohort (embryos) embryos were extracted on GD 17 and scanned with MRI postnatally, as described in the methods of the accompanying paper. Electron microscopy was used to investigate dark neural and glial cells, apoptotic cells, and dividing cells in the hippocampus. In the second cohort (neonates) pups were born and scanned postnatally with manganese enhanced MRI on postnatal day (PND) 3, 5, 7, and 10. Separation-induced ultrasonic vocalizations were acquired on PND 12 and pups were perfused on PND 13. EM analyses were repeated in the neonatal hippocampi. In the third cohort (adults) pups were scanned on PND 25, 35, 60, and 90. Behavioral assessments for anxiety-like behavior with open-field test and sensorimotor gating with prepulse inhibition were performed on PND 35 and 37 respectively. </p> <p>Findings showed altered prenatal body volumes and weight-trajectories, altered brain volumes (especially sustained in females until adulthood), and indications of changes to behavior, including anxiety-like phenotypes in neonates and adolescents. Evidence from electron microscopy suggests increased cell division in the embryo hippocampus. Together these data suggest a profound and sustained impact of early gestation prenatal THC exposure on brain development. For further details on the methods, approach, and results, please see the forthcoming publication.</p> <p>In this dataset you will find the following data:</p> <p>Pregnancy/dam-level outcomes can be found in maternal_outcomes.zip</p> <ul> <li><a href="../api/records/13820978/draft/files/zenodo_pregnancy_README.txt/content" target="_blank" rel="noopener noreferrer">zenodo_pregnancy_README.txt</a>: includes description of the data and fields available in each csv.</li> <li>dam_weights.csv: A spreadsheet including the information related to each dam pooled across the studies</li> <li>nest_quality.csv: A spreadsheet including the manually-rated nest quality from a pilot and the full experiment</li> <li>master_maternal_observations_old_thc.csv: A spreadsheet including data for time spent on and off nest extracted automatically and manually from Ethovision</li> </ul> <p>Embryo outcomes:</p> <ul> <li>zenodo_embryos_README.txt: includes description of the data and fields available in each csv.</li> <li>demographics_for_analysis.csv: A spreadsheet with relevant information for each embryo sample.</li> <li>raw_embryo_mincs.zip: includes 84 embryo scans, full body</li> <li>embryo_heads.zip: includes 57 embryo scans that all passed qc, head only niftis </li> <li>squish_qc.csv: QC of whether the embryos were squished or not</li> <li>em_embryo_hc_mm2csv.csv: cells per mm^2 from electron microscopy</li> </ul> <p>Neonate outcomes:</p> <ul> <li>zenodo_neonates_README.txt: includes description of data and fields available in each csv</li> <li>demographics.csv: A spreadsheet with the demographic information for each pup and timepoint in the study</li> <li>raw_neonate_niftis.zip: 172 scans from neonates in nifti format</li> <li>agreement_qc.csv: quality control file with assessments of raw images</li> <li>milestones_999_as_NA.csv: Record of which milestones were tested and whether they were obtained</li> <li>master_usv.csv: Spreadsheet including data for ultrasonic vocalizations from all tested pups</li> <li>neo_cell_counts_mm2.csv: cells per mm^2 from electron microscopy for the neonates</li> </ul> <p>Adult outcomes: </p> <ul> <li>zenodo_adult_README.txt: includes description of the data and fields available in each csv.</li> <li>demographics.csv: A spreadsheet with the demographic information for each mouse and timepoint in the study</li> <li>adult_raw_niftis.zip: The raw data (before preprocessing) in nifti format</li> <li>master_qc.csv: Quality control assessment of the raw images</li> <li>master_oft.csv: Values for open field test extracted from Ethovision</li> <li>avg_trials_ppi.csv: Data from prepulse inhibition trials, average startle of 100 ms following pulse</li> <li>max_trials_ppi.csv Dat afrom prepulse inhibition trials, maximum startle of 100 ms following pulse</li> </ul>
Behavioral data for: A preclinical model of THC edibles that produces high-dose cannabimimetic responses
<p>No preclinical experimental approach enables the study of voluntary oral consumption of high-concentration Δ<sup>9</sup>-tetrahydrocannabinol (THC) and its intoxicating effects, mainly owing to the aversive response of rodents to THC that limits intake. Here we developed a palatable THC formulation and an optimized access paradigm in mice to drive voluntary consumption.<strong> </strong>THC was formulated in chocolate gelatin (THC-E-gel). Adult male and female mice were allowed <em>ad libitum </em>access for 1 and 2 h. Cannabimimetic responses (hypolocomotion, analgesia, and hypothermia) were measured following access. Levels of THC and its metabolites were measured in blood and brain tissue. Acute acoustic startle responses were measured to investigate THC-induced psychotomimetic behavior. When allowed access for 2 h to THC-E-gel on the second day of a three-day exposure paradigm, adult mice consumed up to ≈30 mg/kg over 2 h which resulted in robust cannabimimetic behavioral responses (hypolocomotion, analgesia and hypothermia). Consumption of the same gelatin decreased on the following 3<sup>rd</sup> day of exposure. Pharmacokinetic analysis show that THC-E-gel consumption led to parallel accumulation of THC and its psychoactive metabolite, 11-OH-THC, in brain, a profile that contrasts with the known rapid decline in brain 11-OH-THC levels following THC intraperitoneal (<em>i.p</em>.) injections. THC-E-gel consumption increased the acoustic startle response in males but not in females, demonstrating a sex-dependent effect of consumption. Thus, while voluntary consumption of THC-E-gel triggered equivalent cannabimimetic responses in male and female mice, it potentiated acoustic startle responses preferentially in males. We build a dose-prediction model that included cannabimimetic behavioral responses elicited by <em>i.p.</em> versus THC-E-gel to test the accuracy and generalizability of this experimental approach and found that it closely predicted the measured acoustic startle results in males and females. In summary, THC-E-gel offers a robust preclinical experimental approach to study cannabimimetic responses triggered by voluntary consumption in mice, including sex-dependent psychotomimetic responses.</p>
An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients
ClinicalTrials.gov study NCT01610700. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Study to Investigate the Efficacy of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis
ClinicalTrials.gov study NCT01610713. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vaping THC From Electronic Cigarettes
ClinicalTrials.gov study NCT02955329. IPD Sharing: NO. Countries: 1. Publications: 8.
A Long-term Safety Extension Study of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis
ClinicalTrials.gov study NCT01610687. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Developing a Mobile Method to Measure THC-induced Impairment
ClinicalTrials.gov study NCT03804840. IPD Sharing: NO. Countries: 1. Publications: 2.
Using Imaging to Assess Effects of THC on Brain Activity
ClinicalTrials.gov study NCT03655717. IPD Sharing: NO. Countries: 1. Publications: 3.
Behavioral data for: A preclinical model of THC edibles that produces high-dose cannabimimetic responses
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Data from: Fatty acid binding protein 7 plays an important modulatory sex-dependent role on brain THC metabolism
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Supplementary material 1 from: McPartland JM, Small E (2020) A classification of endangered high-THC cannabis (Cannabis sativa subsp. indica) domesticates and their wild relatives. PhytoKeys 144: 81-112. https://doi.org/10.3897/phytokeys.144.46700
A classification of endangered high-THC cannabis (Cannabis sativa subsp. indica) domesticates and their wild relatives
Neural basis of adolescent THC-induced potentiation of opioid responses later in life - cFos Sample Images
<p>cFos samples from the brains used in our study. Each .tif file can be viewed in ImageJ to scroll through 3D sections centered in four different regions: Globus Pallidus externus (GPe), prelimbic area (PL), hippocampus, and midline group of the dorsal thalamus. These regions were selected to represent a wide sample of different tissues that might show different trends in over or undercounting of cFos-labeled cells. The files with ".count.tif" show the cells marked by ClearMap. Resampled versions of the whole brain cfos signal are also included as "*.cfos_resampled.tif"</p>
Effects of chronic THC in adolescence on rat play behaviours
<p><b>Background</b>: Cannabis use remains a major public health concern, and its use typically begins in adolescence. Chronic administration of ∆<sup>9</sup>-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, during adolescence can produce deficits in adult learning and memory, stress reactivity and anxiety. One possible mechanism behind the disruptions in adulthood from adolescent exposure to THC includes changes in social behaviours, such as social play, which has been shown to be critical to socio-cognitive development.</p> <p><b>Methods:</b> Here, using an established animal model of adolescent THC exposure in male and female Long–Evans rats, we explored the effects of THC on play behaviour during the chronic administration period. Following puberty onset, as indicated by external changes to the genitalia, THC (5mg/kg) was administered for 14 days. Play behaviour was assessed seven days following the onset of the injection period at approximately 1 hour post treatment. The frequency of nape attacks, the likelihood and tactics of defensive behaviour, and pins were scored and analyzed.</p> <p><b>Results:</b> THC exposure decreased playfulness in adolescent rats including the number of attacks, likelihood of defense and pins compared to control and vehicle treated rats.</p> <p><b>Conclusion: </b>This suggests that THC suppresses both the attack and defense components of social play. This is an important finding because there is evidence that attack and defense may be mediated by different mechanisms. Furthermore, the effect of THC exposure decreasing playfulness occurred similarly in males and females. This study contributes to understanding the long-term ramifications of adolescent THC exposure on healthy brain development. Disruptions in social behaviour during this period could have long-term consequences on adult brain and behaviour, and the interaction between the pharmacological effects of THC and the subsequent effects of decreased sociality should be considered.</p>
Treatment With Cannabis Oil Containing CBD, THC, CBDV or CBG vs. Placebo of Persons With ADHD
ClinicalTrials.gov study NCT05219370. IPD Sharing: YES. Countries: 1. Publications: 2.
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
ClinicalTrials.gov study NCT04436081. IPD Sharing: NO. Countries: 1. Publications: 13.
Delta-THC in Dementia
ClinicalTrials.gov study NCT01608217. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation
ClinicalTrials.gov study NCT01037608. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Osteoarthritis of the Knee Pain Study Using a CBD and THC Sublingual Tablet
ClinicalTrials.gov study NCT04195269. IPD Sharing: NO. Countries: 1. Publications: 10.
Responses to Marijuana-Related Cues Versus Neutral Cues in Adults Taking Tetrahydrocannabinol (THC) - 2
ClinicalTrials.gov study NCT00218504. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
ClinicalTrials.gov study NCT06077292. IPD Sharing: NO. Countries: 1. Publications: 6.
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Annotated Behaviour and Observability Dataset (ABODe)
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