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ShareScore release 0.9.0
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38 results for “TNFR2”
A novel TNFR2 agonist antibody expands highly potent regulatory T cells
<p>Regulatory T cells (T<sub>reg</sub> cells) restrict immune system activity, such as in response to self-antigens, and are switched on by tumor necrosis factor receptor 2 (TNFR2). Therapeutic activation of TNFR2, thereby expanding T<sub>reg</sub> cells and suppressing immune activity, may be beneficial to patients with various inflammatory diseases. Here, we characterized a new human TNFR2-directed antibody agonist isolated from mice. We found that the antibody agonist expanded the number of T<sub>reg</sub> cells within cultures of primary human CD4<sup>+</sup> T cells from healthy donors and patients with type 1 diabetes or Sézary syndrome. These T<sub>reg</sub> cells had increased metabolic gene expression and intracellular itaconate concentrations, characteristics associated with maximally suppressive, anti-inflammatory T<sub>reg</sub> cells. Furthermore, antibody-expanded T<sub>reg</sub> cells repressed the activity of primary human CD8<sup>+</sup> effector T cells (T<sub>eff</sub> cells). Epitope mapping suggested that the antibody bound to TNFR2 through a natural cross-linking surface and that T<sub>reg</sub> cell expansion was independent of the antibody Fc region. In addition, T<sub>reg</sub> cell expansion was not increased by adding either supplemental TNF ligand or a cross-linking reagent, suggesting that the antibody agonist by itself can elicit maximal activity, a notion that was confirmed by increased secretion of soluble TNFR2. Pending in vivo tests, these features indicate that this TNFR2 antibody agonist has the potential to safely and effectively treat various inflammatory disorders.</p>
A novel TNFR2 agonist antibody expands highly potent regulatory T cells
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TNF plays a crucial role in inflammation by signaling via T cell TNFR2 [bulkRNA-seq]
GEO Series GSE188160. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transmembrane TNF-TNFR2 axis promotes generation of human T cell precursors.
GEO Series GSE211400. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Expression data of human Tregs treated with TNFR2 agonist antibody
GEO Series GSE185145. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Effects of TNFR2 deletion on the development of mouse colonic epithelial organoids
GEO Series GSE157751. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Transmembrane TNF-TNFR2 axis promotes generation of human T cell precursors
GEO Series GSE179534. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis [single-cell RNA-seq]
GEO Series GSE169454. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
TNFR2 signaling regulates the immunomodulatory function of oligodendrocyte precursor cells
GEO Series GSE180604. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of Treg and Tconv cells from inflamed tissues of mice that are deficient for TNFR2 in Treg cells
GEO Series GSE165821. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
Opposite functions of microglial and macrophagial TNFR2 in EAE pathogenesis: the good versus the bad.
GEO Series GSE78082. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
TNF plays a crucial role in inflammation by signaling via T cell TNFR2 [scRNA-seq]
GEO Series GSE188161. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Distinct TNF-producing or TNFR2-expressing regulatory T cell subsets cooperate in Treg expansion in cancer and chronic inflammation
GEO Series GSE291595. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq data of human Tregs treated with TNFR2 agonist antibody
GEO Series GSE185144. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
TNFR2 HnRNPK-YAP Signaling Axis Promotes Primary Liver Cancer Development in Hepatic Progenitor Cells
GEO Series GSE166635. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Effect of colonic epithelial knockout of tumor necrosis factor receptor 2 (TNFR2) in dextran sulfate sodium (DSS)-induced colitis
GEO Series GSE230329. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation
GEO Series GSE195557. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Adam17-Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling (aorta)
GEO Series GSE79998. Mus musculus. 15 samples. Type: Expression profiling by array.
Single-cell RNA sequencing reveals the transcriptomic characteristics of Tregs and TNFR2+ Tregs isolated from tumor tissues and peripheral blood of patients with gastric cancer
GEO Series GSE172131. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of TNFR2-knockout mouse colon
GEO Series GSE65408. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.