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20 results for “TRPV4”
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
<p>In humans, skin is a primary thermoregulatory organ, with vasodilation leading to rapid body cooling, whereas in Rodentia the tail performs an analogous function. Many thermodetection mechanisms are likely to be involved including transient receptor potential vanilloid-type 4 (TRPV4), an ion channel with thermosensitive properties. Previous studies have shown that TRPV4 is a vasodilator by local action in blood vessels, so here we investigated whether constitutive TRPV4 activity effects <em>Mus muscularis</em> tail vascular tone and thermoregulation. We measured tail blood flow by pressure plethysmography in lightly sedated Mus muscularis (CD1 strain) at a range of ambient temperatures, with and without intraperitoneal administration of the blood brain barrier crossing TRPV4 antagonist GSK2193874. We also measured heart rate and blood pressure. As expected for a thermoregulatory organ, we found that tail blood flow increased with temperature. However, unexpectedly we found that GSK2193874 increased tail blood flow at all temperatures, and we observed changes in heart rate variability. Since local TRPV4 activation causes vasodilation that would increase tail blood-flow, these data suggest that increases in tail blood flow resulting from the TRPV4 antagonist may arise from a site other than the blood vessels themselves, perhaps in central cardiovascular control centres.</p>
Raw data for: Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulates lipid-dependent channel activity
<p>This repository contains raw data and code related to "Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulates lipid-dependent channel activity" by Goretzki et al.</p> <p>Included are molecular dynamics parameter files, initial structures after system equilibration, production trajectories, and final structures of simulations of:<br> 1. coarse-grained IDRs on membrane, and force and position data for restrained c-termini. Trajectories are subsampled with one frame every 50 ns.<br> 2. The tetrameric TRPV4 core in a POPC in atomistic resolution. Trajectories are sampled with one frame every 1 ns. <br> 3. The isolated ARD in solution in atomistic resolution. Trajectories are subsampled with one frame every 1 ns.</p> <p>Contact information:<br> Name: Stefan L. Schaefer<br> Institution: Department of Theoretical Biophysics, Max Planck Institute of Biophysics<br> Address: Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany<br> Email: stefan.schaefer@biophys.mpg.de</p> <p>Name: Ainara Claveras Cabezudo<br> Institution: Department of Theoretical Biophysics, Max Planck Institute of Biophysics<br> Address: Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany<br> Email: ainara.claveras@biophys.mpg.de</p>
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
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Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain
ClinicalTrials.gov study NCT07095608. IPD Sharing: Not stated. Countries: 1. Publications: 9.
A Study to Evaluate the Effect of the Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Blocker, GSK2798745, on Pulmonary Gas Transfer and Respiration in Patients With Congestive Heart Failure
ClinicalTrials.gov study NCT02497937. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of TRPV4 in methylation of the CpG sites on miR146a promoter
GEO Series GSE271253. synthetic construct; Mus musculus. 11 samples. Type: Methylation profiling by high throughput sequencing.
Novel Crosstalk Between Mechanosensitive TRPV4 and NF-κB Inhibits Pulmonary Inflammation
GEO Series GSE295714. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
GEO Series GSE225446. Homo sapiens. 31 samples. Type: Expression profiling by high throughput sequencing.
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels
GEO Series GSE294684. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
In vitro Examination of Piezo1-TRPV4 Dynamics: Implications for Placental Endothelial Function in Normal and Preeclamptic Pregnancies
GEO Series GSE274555. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
The Natural History of TRPV4 Neuropathy
ClinicalTrials.gov study NCT05600764. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The chondrocyte “mechanome”: Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 drives unique transcriptional signatures
GEO Series GSE269159. Sus scrofa. 120 samples. Type: Expression profiling by high throughput sequencing.
CFTR deficiency modulates the activity of endothelial mechanosensitive channels TRPV4 and PIEZO1; and drives endothelial barrier failure.
GEO Series GSE244214. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice
GEO Series GSE263775. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Loss of TRPV4 reduces pancreatic cancer growth and metastasis
GEO Series GSE296050. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes
GEO Series GSE40280. Mus musculus. 4 samples. Type: Expression profiling by array.
Colonic TRPV4 overexpression is related to constipation severity
GEO Series GSE208164. Homo sapiens. 2 samples. Type: Expression profiling by array.
Inhibition of TRPV4 rescues impaired excitability and social deficits in NAc-specific Shank3-deficient mice.
GEO Series GSE139683. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Skeletal dysplasia-causing mutations in TRPV4 alter the chondrocyte’s transcriptomic response to mechanical loading
GEO Series GSE283659. Mus musculus. 71 samples. Type: Expression profiling by high throughput sequencing.
TRPV4 activation induces TMJ degeneration via p38 MAPK/c-Fos/CXCLs axis
GEO Series GSE280821. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.