Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
36
datasets available to search
ShareScore release 0.9.0
Dataset results
36 results for “Tau protein”
Nuclear Magnetic resonance Dataset of 2D spectra of S100B and Tau to study their protein-protein interaction
<p>Nuclear Magnetic resonance dataset of 2D spectra corresponding to raw data of research published in Nature Communication in a communication entitled "Dynamic interactions and Ca2+ 1 -binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding" by Moreira G. et al.</p> <p>Dataset corresponds to</p> <p>raw data files in Bruker format of NMR 2D spectra (ser), associated with files of acquisition parameters and processing parameters (pdata),</p> <p>files in .ucsf format that can be read with NMRFAM-Sparky (free download) of 2D spectra (in sub-directory pdata/1)</p> <p>files of chemical shift value lists that can be read as text files or in NMRFAM sparky together with the corresponding ucsf files.</p> <p>physico-chemical conditions are found in title in pdata\1</p> <p>Data were acquired on a Bruker 900-MHz spectrometer equipped with a triple-resonance cryogenic probe (Bruker, Karlsruhe, Germany)</p>
Triple-resonance NMR spectra of Tau 1-239 protein fragment acquired at 5 C, 10 C and 15 C
<p>Dataset used in a paper "Using temperature coefficients to support resonance<br>assignment of intrinsically disordered proteins" by Paulina Putko, Javier Agustin Romero, Christian F. Pantoja, Markus<br>Zweckstetter, Krzysztof Kazimierczuk, and Anna Zawadzka-Kazimierczuk</p> <p>The following spectra have been collected:</p> <table> <tbody> <tr> <td>Experiments<br>T : 5 C</td> <td>NUS points<br>(Recorded)</td> <td>NS (scans)<br>(Recorded)</td> </tr> <tr> <td>HNCO</td> <td>600</td> <td>4</td> </tr> <tr> <td>HN(CA)CO</td> <td>1000</td> <td>16</td> </tr> <tr> <td>HNCA</td> <td>600</td> <td>8</td> </tr> <tr> <td>HN(CO)CA</td> <td>450</td> <td>8</td> </tr> <tr> <td> <p>CBCA(CO)NH</p> <p>(HAHB)CBCA(CO)NH</p> </td> <td>1000</td> <td> </td> </tr> <tr> <td>Experiments<br>T : 10 C</td> <td>NUS points<br>(Recorded)</td> <td>NS (scans)<br>(Recorded)</td> </tr> <tr> <td>HNCO</td> <td>600</td> <td>4</td> </tr> <tr> <td>HN(CO)CA</td> <td>450</td> <td>8</td> </tr> <tr> <td>(HAHB)CBCA(CO)NH</td> <td>1000</td> <td>8</td> </tr> <tr> <td>Experiments<br>T : 15 C</td> <td>NUS points<br>(Recorded)</td> <td>NS (scans)<br>(Recorded)</td> </tr> <tr> <td>HNCO</td> <td> 600</td> <td> 4</td> </tr> <tr> <td>HN(CO)CA</td> <td> 450</td> <td> 8</td> </tr> <tr> <td>(HAHB)CBCA(CO)NH</td> <td> 1000</td> <td> 8</td> </tr> <tr> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table>
Data for: Conformational Dependence of Chemical Shifts in the Proline Rich Region of TAU Protein
<div> <div> <div> <p>Nuclear magnetic resonance (NMR) is an important method for structure elucidation of proteins, as it is an easy accessible and well understood method. To characterize intrinsically disordered proteins (IDPs) using computational models it is often necessary to analyze and integrate calculated observables with measurements derived from solution NMR experiments.</p> <p>In this case study we investigate whether and which chemical shifts of the proline-rich region of Tau protein (residues 210-240) offer information about the conformational state to distinguish two different microscopic conformers. Using multiple computational methods, chemical shifts of those two conformationally distinct structures are calculated. The different methods are compared regarding their ability to compute chemical shifts that are sensitive to conformational change.</p> <p>The analysis of the data shows significant differences between the available methods and gives suggestions to an improved pathway for ensemble reweighting. Nevertheless, the variation in the chemical shifts which are predicted for configurations that are commonly considered to belong to the same conformation is such that this obscures a comparison between distinct conformations. Conformational sensitivity is found for up to ∼26% of calculated chemical shifts. It is found to be unrelated with atom element and had minor relation with the change of the corresponding φ dihedral angle.</p> </div> </div> </div>
Data from: BioID2-based tau interactome reveals novel and known protein interactions associated with multiple cellular pathways
Open the record for dataset details and reuse information.
Serum levels of tau protein increase according to the severity of the injury in DAI rat model
<p><span><span><span><span><span><span><span><span><span><span><span>Traumatic brain injury (TBI) in the form of diffuse axonal injury (DAI) is difficult to diagnose in the early phase of the injury. Early diagnosis of DAI may provide opportunity for developing treatment and management strategies. Tau protein has been demonstrated to increase in the early phase of TBI with high diagnostic accuracy in patients with DAI. We tested the biological plausibility of tau protein using a rat DAI model by evaluating the association between serum tau levels and the severity of brain injury. DAI was induced in animals using the Marmarou model. After a survival of 60 minutes, rats were anesthetized and sacrificed after obtaining blood samples (5ml) from the heart. Eighteen rats were employed in the present study and were randomly subjected to sham-operated control (n=4), mild DAI (n=7), and severe DAI (n=7). Of seven severe DAI rats, two rats that had focal injury caused by skull fracture were excluded in the measurement of tau protein level. The serum levels of tau protein in the rat DAI model were found to increase significantly and consistently according to the severity of the injury. Rats with DAI showed significantly higher serum levels of tau protein compared to sham rats; the severe DAI rats had higher levels of tau than moderate DAI and sham rats (sham vs. mild, <i>P</i>=0.02; mild vs. severe, <i>P</i>=0.02). In conclusion, serum tau protein levels may be useful as a biomarker for diagnosing and estimating the severity of DAI in the early phase.</span></span></span></span></span></span></span></span></span></span></span></p> <div> </div>
Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
<p>Dataset pertaining to Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein</p>
Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
ClinicalTrials.gov study NCT03080051. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Tau-217 Protein.
ClinicalTrials.gov study NCT06366412. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies
ClinicalTrials.gov study NCT02531360. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Serum levels of tau protein increase according to the severity of the injury in DAI rat model
Open the record for dataset details and reuse information.
Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
GEO Series GSE148716. Mus musculus; Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing; Other.
Identification of early neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant tau protein
GEO Series GSE62935. Homo sapiens. 28 samples. Type: Expression profiling by array.
CRISPR/Cas9 genome editing in human neural progenitor cells demonstrates astrocyte pathology in frontotemporal dementia caused by mutant TAU protein
GEO Series GSE79557. Homo sapiens. 30 samples. Type: Expression profiling by array.
Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein
ClinicalTrials.gov study NCT03071224. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain
ClinicalTrials.gov study NCT03510572. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases
ClinicalTrials.gov study NCT05260151. IPD Sharing: NO. Countries: 1. Publications: 0.
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
ClinicalTrials.gov study NCT07348276. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of Tau Protein in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants
ClinicalTrials.gov study NCT03239561. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome
ClinicalTrials.gov study NCT04572477. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Validation of an Alzheimer's Disease Marker by Fecal Assay of Amyloid Peptides and Tau Proteins
ClinicalTrials.gov study NCT06481878. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.